ENSG00000173960

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309033 ENSG00000173960 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN2A protein_coding protein_coding 9.016183 2.884281 16.214 0.5172234 0.4333008 2.486853 3.14548819 0.58250105 5.2073852 0.11306475 0.2419807 3.1384374 0.31107917 0.20870000 0.320833333 0.11213333 2.965535e-01 3.933069e-08 FALSE TRUE
ENST00000404924 ENSG00000173960 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN2A protein_coding protein_coding 9.016183 2.884281 16.214 0.5172234 0.4333008 2.486853 0.08953962 0.22601178 0.0353125 0.17962773 0.0353125 -2.3808779 0.01660000 0.07336667 0.002266667 -0.07110000 3.684210e-01 3.933069e-08 FALSE TRUE
ENST00000446425 ENSG00000173960 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN2A protein_coding processed_transcript 9.016183 2.884281 16.214 0.5172234 0.4333008 2.486853 0.90661144 0.77273846 0.9292922 0.09958345 0.0689968 0.2630437 0.14454167 0.27663333 0.057600000 -0.21903333 1.225795e-06 3.933069e-08 TRUE FALSE
MSTRG.18039.10 ENSG00000173960 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN2A protein_coding   9.016183 2.884281 16.214 0.5172234 0.4333008 2.486853 0.30709827 0.34476711 0.0000000 0.19689646 0.0000000 -5.1488004 0.05884167 0.10750000 0.000000000 -0.10750000 6.661408e-02 3.933069e-08 TRUE TRUE
MSTRG.18039.11 ENSG00000173960 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN2A protein_coding   9.016183 2.884281 16.214 0.5172234 0.4333008 2.486853 1.82002999 0.14228283 6.4945534 0.14228283 1.1047411 5.4166248 0.16521250 0.07340000 0.397533333 0.32413333 1.717267e-01 3.933069e-08 FALSE TRUE
MSTRG.18039.12 ENSG00000173960 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN2A protein_coding   9.016183 2.884281 16.214 0.5172234 0.4333008 2.486853 0.27375537 0.30731119 0.2661650 0.30731119 0.2661650 -0.2003681 0.03566250 0.08260000 0.017100000 -0.06550000 8.792960e-01 3.933069e-08 FALSE TRUE
MSTRG.18039.5 ENSG00000173960 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN2A protein_coding   9.016183 2.884281 16.214 0.5172234 0.4333008 2.486853 0.39238741 0.32332279 0.0000000 0.12417245 0.0000000 -5.0588480 0.04172083 0.10223333 0.000000000 -0.10223333 3.933069e-08 3.933069e-08   FALSE
MSTRG.18039.8 ENSG00000173960 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN2A protein_coding   9.016183 2.884281 16.214 0.5172234 0.4333008 2.486853 0.65183303 0.02976287 1.0169810 0.02976287 0.5128446 4.6908437 0.08282083 0.01536667 0.064433333 0.04906667 7.963283e-01 3.933069e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000173960 E001 1.4207165 0.0135150175 0.0725272218 0.229833745 2 23927285 23927286 2 + 0.244 0.575 1.868
ENSG00000173960 E002 3.6738254 0.0343577006 0.0288285599 0.123877243 2 23927287 23927302 16 + 0.493 0.857 1.552
ENSG00000173960 E003 4.1612088 0.0893031450 0.0189798347 0.092387425 2 23927303 23927311 9 + 0.513 0.934 1.748
ENSG00000173960 E004 20.7308127 0.0080952836 0.0001572372 0.002186221 2 23927312 23927615 304 + 1.146 1.486 1.188
ENSG00000173960 E005 2.4969895 0.0338935777 0.4243892362 0.646858677 2 23939540 23939662 123 + 0.426 0.575 0.728
ENSG00000173960 E006 1.3309947 0.0323685336 0.6931041323   2 23939663 23939676 14 + 0.314 0.228 -0.619
ENSG00000173960 E007 0.3559677 0.4640243546 1.0000000000   2 23940295 23940415 121 + 0.117 0.000 -8.729
ENSG00000173960 E008 0.2735028 0.0274424043 0.2690582295   2 23940416 23940439 24 + 0.061 0.227 2.189
ENSG00000173960 E009 1.8202156 0.0114197924 0.0398575041 0.154357276 2 23940440 23940459 20 + 0.280 0.648 1.927
ENSG00000173960 E010 1.9510838 0.0106552800 0.0136269326 0.072882545 2 23940460 23940462 3 + 0.280 0.710 2.189
ENSG00000173960 E011 5.3742196 0.0512913512 0.4335767743 0.653948297 2 23940463 23940473 11 + 0.682 0.813 0.530
ENSG00000173960 E012 38.9300063 0.0166887023 0.4845854044 0.690236362 2 23940474 23940648 175 + 1.484 1.546 0.213
ENSG00000173960 E013 1.5954914 0.0625525644 0.1262533995 0.325906412 2 23952552 23952587 36 + 0.280 0.575 1.608
ENSG00000173960 E014 0.5823548 0.0215074314 0.1521035463   2 23957329 23957445 117 + 0.115 0.376 2.186
ENSG00000173960 E015 42.1579378 0.0039377043 0.2888318729 0.529440485 2 23958301 23958355 55 + 1.514 1.589 0.256
ENSG00000173960 E016 2.3396447 0.1404858820 0.7839382061 0.886881782 2 23968919 23969035 117 + 0.443 0.490 0.235
ENSG00000173960 E017 55.2925769 0.0007497526 0.7724631343 0.880139236 2 23971276 23971363 88 + 1.642 1.627 -0.053
ENSG00000173960 E018 51.8362394 0.0008076119 0.8104497652 0.902485492 2 23971364 23971414 51 + 1.610 1.627 0.058
ENSG00000173960 E019 78.9961388 0.0012032551 0.7793906717 0.884376647 2 23976969 23977075 107 + 1.797 1.785 -0.041
ENSG00000173960 E020 0.1614157 0.0329494649 1.0000000000   2 23977076 23977320 245 + 0.061 0.000 -8.635
ENSG00000173960 E021 92.2487493 0.0006579261 0.1853379987 0.411006244 2 23982896 23983033 138 + 1.870 1.809 -0.206
ENSG00000173960 E022 101.4170573 0.0004062482 0.3909419304 0.621114524 2 23984673 23984831 159 + 1.909 1.873 -0.119
ENSG00000173960 E023 325.9974564 0.0002183772 0.4963655358 0.698459510 2 23999672 24001191 1520 + 2.402 2.418 0.056
ENSG00000173960 E024 66.4985108 0.0041511014 0.0071925477 0.045544578 2 24001192 24002210 1019 + 1.750 1.573 -0.600
ENSG00000173960 E025 218.4716769 0.0004778928 0.0621321133 0.207591522 2 24002211 24004909 2699 + 2.241 2.189 -0.175