ENSG00000173905

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309027 ENSG00000173905 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLIM4 protein_coding protein_coding 18.26417 9.880267 29.6019 1.63588 0.6506301 1.582096 2.855833 0.4139742 5.331578 0.03877715 0.2321928 3.6552178 0.1071750 0.04316667 0.1800000 0.1368333 2.442136e-09 2.442136e-09 FALSE TRUE
ENST00000470487 ENSG00000173905 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLIM4 protein_coding protein_coding 18.26417 9.880267 29.6019 1.63588 0.6506301 1.582096 9.181861 7.6433756 13.364441 1.97680545 0.7718993 0.8053105 0.6355708 0.74353333 0.4509667 -0.2925667 1.462843e-01 2.442136e-09 FALSE TRUE
MSTRG.24028.2 ENSG00000173905 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLIM4 protein_coding   18.26417 9.880267 29.6019 1.63588 0.6506301 1.582096 6.187345 1.7506525 10.755680 0.41217430 0.6507148 2.6122574 0.2551417 0.20446667 0.3640667 0.1596000 4.733809e-01 2.442136e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000173905 E001 193.5796754 0.0250025189 9.288239e-04 9.328504e-03 3 168008689 168009472 784 - 2.139 2.435 0.987
ENSG00000173905 E002 435.7518086 0.0003061167 1.249252e-15 2.065741e-13 3 168009473 168010234 762 - 2.547 2.706 0.530
ENSG00000173905 E003 205.1329476 0.0002349636 4.716507e-01 6.812983e-01 3 168010235 168010418 184 - 2.265 2.300 0.119
ENSG00000173905 E004 153.6133842 0.0017614940 7.207124e-01 8.486343e-01 3 168010743 168010823 81 - 2.143 2.171 0.097
ENSG00000173905 E005 166.0699112 0.0014485020 8.064680e-01 9.000192e-01 3 168024526 168024594 69 - 2.184 2.193 0.028
ENSG00000173905 E006 230.7789444 0.0002856163 2.251473e-01 4.595466e-01 3 168024928 168025095 168 - 2.332 2.318 -0.047
ENSG00000173905 E007 162.1569975 0.0002820515 3.235494e-02 1.342507e-01 3 168027728 168027837 110 - 2.188 2.139 -0.164
ENSG00000173905 E008 16.6211837 0.0020900874 5.861469e-02 1.996735e-01 3 168029220 168029222 3 - 1.248 1.083 -0.591
ENSG00000173905 E009 106.6197804 0.0003581174 8.067454e-01 9.001867e-01 3 168029223 168029302 80 - 1.992 1.999 0.025
ENSG00000173905 E010 178.3996777 0.0003487813 4.596309e-02 1.699490e-01 3 168029780 168030036 257 - 2.228 2.186 -0.142
ENSG00000173905 E011 294.9642146 0.0001939113 2.776164e-03 2.203685e-02 3 168032520 168032852 333 - 2.446 2.396 -0.170
ENSG00000173905 E012 191.9034884 0.0033681960 1.147334e-02 6.429635e-02 3 168036836 168036994 159 - 2.268 2.181 -0.291
ENSG00000173905 E013 106.1450258 0.0004050000 3.050678e-01 5.456698e-01 3 168040786 168040869 84 - 1.997 1.975 -0.076
ENSG00000173905 E014 0.7608862 0.1996032620 2.023568e-01   3 168041118 168041391 274 - 0.148 0.400 1.890
ENSG00000173905 E015 147.0641909 0.0007449117 1.921471e-02 9.320211e-02 3 168041392 168041474 83 - 2.149 2.085 -0.215
ENSG00000173905 E016 194.5405495 0.0004612609 1.385789e-04 1.963448e-03 3 168043379 168043529 151 - 2.279 2.184 -0.318
ENSG00000173905 E017 117.1200094 0.0003483723 8.634435e-03 5.220991e-02 3 168044828 168044881 54 - 2.056 1.977 -0.266
ENSG00000173905 E018 98.8756924 0.0003881793 1.825346e-02 8.986154e-02 3 168046950 168046999 50 - 1.984 1.907 -0.258
ENSG00000173905 E019 102.6647347 0.0004018188 2.165640e-02 1.014643e-01 3 168048291 168048365 75 - 1.998 1.925 -0.244
ENSG00000173905 E020 180.6790106 0.0016152749 5.532607e-01 7.385522e-01 3 168095099 168096003 905 - 2.212 2.249 0.121