ENSG00000173889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000465896 ENSG00000173889 HEK293_OSMI2_6hA HEK293_TMG_6hB PHC3 protein_coding processed_transcript 3.736785 3.121735 6.283624 0.2473813 0.2264048 1.006929 0.02762531 0.22100246 0.0000000 0.11200483 0.0000000 -4.5298363 0.009504167 0.07603333 0.00000000 -0.07603333 0.238716511 0.007659866 FALSE FALSE
ENST00000467570 ENSG00000173889 HEK293_OSMI2_6hA HEK293_TMG_6hB PHC3 protein_coding protein_coding 3.736785 3.121735 6.283624 0.2473813 0.2264048 1.006929 0.24028219 0.07963153 0.3992186 0.04237289 0.1613842 2.1907937 0.073570833 0.02776667 0.06256667 0.03480000 0.754450631 0.007659866 FALSE TRUE
ENST00000494943 ENSG00000173889 HEK293_OSMI2_6hA HEK293_TMG_6hB PHC3 protein_coding protein_coding 3.736785 3.121735 6.283624 0.2473813 0.2264048 1.006929 0.22878374 0.41066806 0.2480043 0.20655485 0.1267457 -0.7052872 0.099720833 0.12203333 0.04050000 -0.08153333 0.864091777 0.007659866 FALSE TRUE
ENST00000495893 ENSG00000173889 HEK293_OSMI2_6hA HEK293_TMG_6hB PHC3 protein_coding protein_coding 3.736785 3.121735 6.283624 0.2473813 0.2264048 1.006929 1.60231794 0.74442385 3.0763205 0.02751284 0.1001663 2.0324407 0.391158333 0.24220000 0.49176667 0.24956667 0.007659866 0.007659866 FALSE TRUE
MSTRG.24051.1 ENSG00000173889 HEK293_OSMI2_6hA HEK293_TMG_6hB PHC3 protein_coding   3.736785 3.121735 6.283624 0.2473813 0.2264048 1.006929 0.76358195 1.08359181 0.9670324 0.13417521 0.2438145 -0.1625960 0.184637500 0.34506667 0.15176667 -0.19330000 0.097283901 0.007659866 TRUE TRUE
MSTRG.24051.3 ENSG00000173889 HEK293_OSMI2_6hA HEK293_TMG_6hB PHC3 protein_coding   3.736785 3.121735 6.283624 0.2473813 0.2264048 1.006929 0.25716375 0.12650671 0.2816691 0.03007531 0.1564323 1.0953606 0.061245833 0.03940000 0.04570000 0.00630000 0.976019286 0.007659866 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000173889 E001 0.6072928 0.0197608271 4.444997e-01   3 170077614 170077638 25 - 0.164 0.280 0.975
ENSG00000173889 E002 0.1779838 0.0328210509 1.000000e+00   3 170086659 170086665 7 - 0.090 0.000 -10.701
ENSG00000173889 E003 0.1779838 0.0328210509 1.000000e+00   3 170086666 170086731 66 - 0.090 0.000 -10.701
ENSG00000173889 E004 1.8979490 0.0106272281 6.360083e-01 7.942878e-01 3 170086732 170087101 370 - 0.487 0.372 -0.607
ENSG00000173889 E005 338.9318444 0.0080922078 3.377959e-07 1.096226e-05 3 170087584 170095220 7637 - 2.576 2.334 -0.808
ENSG00000173889 E006 115.3690772 0.0016022432 5.743799e-02 1.970405e-01 3 170095221 170097171 1951 - 2.078 1.959 -0.399
ENSG00000173889 E007 42.5841898 0.0015786647 9.310786e-05 1.409005e-03 3 170097172 170097384 213 - 1.545 1.718 0.588
ENSG00000173889 E008 32.0377593 0.0014398365 4.654788e-05 7.824816e-04 3 170102479 170102566 88 - 1.405 1.616 0.725
ENSG00000173889 E009 35.9067696 0.0013638028 2.009566e-04 2.685901e-03 3 170102567 170102685 119 - 1.471 1.648 0.606
ENSG00000173889 E010 17.0797958 0.0020213706 1.202265e-01 3.162029e-01 3 170102686 170102710 25 - 1.203 1.291 0.309
ENSG00000173889 E011 30.3308331 0.0013543648 1.694949e-01 3.898967e-01 3 170102802 170102934 133 - 1.457 1.502 0.155
ENSG00000173889 E012 30.6905831 0.0012426933 1.361704e-02 7.285028e-02 3 170106832 170106946 115 - 1.435 1.549 0.391
ENSG00000173889 E013 45.0797359 0.0010757575 6.960769e-02 2.239842e-01 3 170113360 170113519 160 - 1.620 1.674 0.181
ENSG00000173889 E014 0.1426347 0.0315873600 1.000000e+00   3 170117123 170117225 103 - 0.090 0.000 -10.708
ENSG00000173889 E015 50.8724351 0.0008978278 4.620400e-02 1.705428e-01 3 170117226 170117476 251 - 1.672 1.728 0.190
ENSG00000173889 E016 30.6610967 0.0012773742 1.399442e-02 7.432185e-02 3 170122591 170122744 154 - 1.435 1.549 0.390
ENSG00000173889 E017 4.9583737 0.0061872138 9.195950e-01 9.620012e-01 3 170128340 170128387 48 - 0.766 0.742 -0.097
ENSG00000173889 E018 1.6384753 0.0483801379 5.880722e-01 7.623957e-01 3 170128388 170128408 21 - 0.378 0.448 0.382
ENSG00000173889 E019 80.2393214 0.0006526172 4.151759e-01 6.399129e-01 3 170128684 170129307 624 - 1.891 1.879 -0.042
ENSG00000173889 E020 24.6620949 0.0016169641 4.284657e-01 6.498640e-01 3 170129308 170129384 77 - 1.384 1.397 0.045
ENSG00000173889 E021 30.7174285 0.0014718290 1.587641e-01 3.749224e-01 3 170129385 170129552 168 - 1.467 1.514 0.162
ENSG00000173889 E022 0.0000000       3 170136366 170136418 53 -      
ENSG00000173889 E023 21.7082609 0.0023663539 3.728508e-02 1.476909e-01 3 170136419 170136533 115 - 1.298 1.412 0.398
ENSG00000173889 E024 17.5642964 0.0021144846 1.757345e-01 3.980921e-01 3 170136534 170136595 62 - 1.221 1.291 0.245
ENSG00000173889 E025 21.3968019 0.0020975065 6.361872e-01 7.944353e-01 3 170136596 170136665 70 - 1.336 1.329 -0.025
ENSG00000173889 E026 0.3337900 0.0271092005 5.650913e-01   3 170136666 170136670 5 - 0.090 0.162 0.976
ENSG00000173889 E027 25.1188245 0.0017508734 4.250933e-01 6.473347e-01 3 170145423 170145521 99 - 1.392 1.405 0.045
ENSG00000173889 E028 0.3559677 0.4000454704 6.312088e-01   3 170147248 170149085 1838 - 0.168 0.000 -10.746
ENSG00000173889 E029 15.8917843 0.0021061086 8.273901e-01 9.122714e-01 3 170149086 170149133 48 - 1.227 1.164 -0.225
ENSG00000173889 E030 22.8716825 0.0019535773 7.418639e-01 8.615752e-01 3 170149134 170149244 111 - 1.359 1.339 -0.069
ENSG00000173889 E031 0.2027342 0.0340130922 2.205526e-01   3 170150607 170150709 103 - 0.000 0.162 11.204
ENSG00000173889 E032 0.9806365 0.0172671820 6.846019e-02   3 170169718 170170731 1014 - 0.377 0.000 -13.235
ENSG00000173889 E033 1.1115047 0.0153778711 3.027870e-01   3 170170732 170171085 354 - 0.377 0.162 -1.612
ENSG00000173889 E034 0.3393995 0.0274424043 5.134014e-01   3 170171086 170171262 177 - 0.165 0.000 -11.702
ENSG00000173889 E035 0.1779838 0.0328210509 1.000000e+00   3 170171263 170171372 110 - 0.090 0.000 -10.701
ENSG00000173889 E036 14.7536239 0.0024175862 8.563762e-01 9.284557e-01 3 170171373 170171389 17 - 1.190 1.163 -0.095
ENSG00000173889 E037 16.2106403 0.0054811801 6.343484e-01 7.931518e-01 3 170171390 170171450 61 - 1.250 1.162 -0.310
ENSG00000173889 E038 23.9017157 0.0015458307 4.643487e-01 6.761304e-01 3 170172557 170172700 144 - 1.372 1.381 0.033
ENSG00000173889 E039 12.9517626 0.0082961644 6.552425e-01 8.068269e-01 3 170172701 170172712 12 - 1.149 1.058 -0.329
ENSG00000173889 E040 0.1426347 0.0315873600 1.000000e+00   3 170176865 170176925 61 - 0.090 0.000 -10.708
ENSG00000173889 E041 26.9430723 0.0014923130 9.558503e-01 9.798292e-01 3 170178773 170178938 166 - 1.439 1.398 -0.142
ENSG00000173889 E042 1.5652042 0.0123046515 4.239676e-01 6.465236e-01 3 170181687 170181701 15 - 0.454 0.279 -1.028
ENSG00000173889 E043 11.1303108 0.0028122112 4.506763e-01 6.661522e-01 3 170181702 170181749 48 - 1.105 0.982 -0.449