ENSG00000173599

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393958 ENSG00000173599 HEK293_OSMI2_6hA HEK293_TMG_6hB PC protein_coding protein_coding 15.03437 22.32709 9.677157 3.979831 0.3557677 -1.205296 12.0943280 19.073877 6.3019384 2.98675523 0.9908821 -1.5961993 0.78456667 0.862266667 0.64643333 -0.21583333 0.1862138511 7.31141e-05 FALSE  
ENST00000393960 ENSG00000173599 HEK293_OSMI2_6hA HEK293_TMG_6hB PC protein_coding protein_coding 15.03437 22.32709 9.677157 3.979831 0.3557677 -1.205296 0.9114255 1.028571 0.7471497 0.47709029 0.4130747 -0.4559489 0.06502917 0.042933333 0.08033333 0.03740000 0.8864425288 7.31141e-05 FALSE  
ENST00000530259 ENSG00000173599 HEK293_OSMI2_6hA HEK293_TMG_6hB PC protein_coding retained_intron 15.03437 22.32709 9.677157 3.979831 0.3557677 -1.205296 0.3923664 0.181383 0.7907242 0.06661827 0.1474951 2.0648428 0.03238750 0.008566667 0.08080000 0.07223333 0.0000731141 7.31141e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000173599 E001 1.0055068 0.0838371123 2.759167e-01   11 66848162 66848245 84 - 0.434 0.234 -1.267
ENSG00000173599 E002 1.0691906 0.2805200877 1.287027e-01   11 66848417 66848419 3 - 0.522 0.182 -2.155
ENSG00000173599 E003 1.6055272 0.0745378603 3.010264e-01 0.5414808380 11 66848420 66848493 74 - 0.518 0.319 -1.086
ENSG00000173599 E004 0.8923043 0.1908372102 5.082933e-01   11 66848494 66848512 19 - 0.334 0.191 -1.065
ENSG00000173599 E005 0.6895701 0.0673176499 2.841913e-01   11 66848513 66848519 7 - 0.332 0.135 -1.658
ENSG00000173599 E006 8.1959421 0.0088820781 4.882232e-01 0.6928115812 11 66848520 66848538 19 - 0.827 0.919 0.352
ENSG00000173599 E007 9.1477960 0.0086288472 4.244367e-01 0.6468758428 11 66848539 66848544 6 - 0.862 0.964 0.385
ENSG00000173599 E008 9.3505302 0.0145587158 3.933690e-01 0.6230353427 11 66848545 66848548 4 - 0.862 0.973 0.420
ENSG00000173599 E009 9.3505302 0.0145587158 3.933690e-01 0.6230353427 11 66848549 66848549 1 - 0.862 0.973 0.420
ENSG00000173599 E010 12.1742278 0.0512577055 1.314571e-01 0.3340880532 11 66848550 66848564 15 - 0.861 1.096 0.876
ENSG00000173599 E011 63.2892447 0.0035582157 1.287449e-01 0.3298252807 11 66848565 66848645 81 - 1.670 1.761 0.308
ENSG00000173599 E012 306.6417097 0.0004421950 4.581663e-03 0.0323805285 11 66848646 66849147 502 - 2.368 2.437 0.230
ENSG00000173599 E013 183.9954912 0.0002626602 1.136741e-03 0.0109423384 11 66849230 66849370 141 - 2.122 2.223 0.336
ENSG00000173599 E014 186.4999614 0.0002993566 3.348053e-05 0.0005927702 11 66849611 66849766 156 - 2.107 2.237 0.436
ENSG00000173599 E015 109.0936794 0.0005434811 5.470366e-03 0.0370682524 11 66849767 66849859 93 - 1.887 2.001 0.384
ENSG00000173599 E016 151.4538760 0.0003573455 1.591947e-02 0.0814918530 11 66849937 66850065 129 - 2.053 2.135 0.272
ENSG00000173599 E017 105.0319282 0.0004030597 9.209772e-01 0.9627235831 11 66850066 66850116 51 - 1.958 1.960 0.007
ENSG00000173599 E018 211.1920234 0.0002769745 5.921296e-01 0.7650869508 11 66850220 66850464 245 - 2.273 2.256 -0.055
ENSG00000173599 E019 148.1251417 0.0003617469 5.729789e-01 0.7523096320 11 66850674 66850853 180 - 2.095 2.113 0.059
ENSG00000173599 E020 90.6295490 0.0004177038 1.742087e-01 0.3961378466 11 66850854 66850923 70 - 1.853 1.911 0.196
ENSG00000173599 E021 158.8091363 0.0004277375 3.315436e-01 0.5703953223 11 66851040 66851280 241 - 2.117 2.147 0.102
ENSG00000173599 E022 92.6663908 0.0011099932 3.769662e-01 0.6098302296 11 66851790 66851851 62 - 1.877 1.913 0.121
ENSG00000173599 E023 95.7118067 0.0029619354 4.467034e-01 0.6632149773 11 66851852 66851946 95 - 1.894 1.924 0.102
ENSG00000173599 E024 119.7862298 0.0018395355 7.543528e-01 0.8693081383 11 66852439 66852603 165 - 2.029 2.013 -0.055
ENSG00000173599 E025 62.4941209 0.0017973072 6.803590e-01 0.8229505733 11 66852604 66852660 57 - 1.752 1.726 -0.089
ENSG00000173599 E026 0.0000000       11 66852743 66852746 4 -      
ENSG00000173599 E027 54.5131417 0.0007687703 1.688187e-01 0.3890051741 11 66852747 66852777 31 - 1.734 1.659 -0.255
ENSG00000173599 E028 75.4988801 0.0005677944 2.047949e-01 0.4356726679 11 66852778 66852836 59 - 1.864 1.804 -0.201
ENSG00000173599 E029 4.4224990 0.0063544156 7.123087e-04 0.0075453092 11 66852837 66852962 126 - 0.981 0.503 -1.973
ENSG00000173599 E030 76.0780020 0.0005345549 3.384921e-01 0.5766388454 11 66853239 66853302 64 - 1.857 1.812 -0.152
ENSG00000173599 E031 90.6699125 0.0009525139 5.870618e-01 0.7616648599 11 66853303 66853383 81 - 1.918 1.894 -0.081
ENSG00000173599 E032 0.5885118 0.0513825992 2.834907e-01   11 66853384 66853451 68 - 0.330 0.135 -1.649
ENSG00000173599 E033 0.1308682 0.0326491905 1.000000e+00   11 66855027 66855095 69 - 0.000 0.072 9.344
ENSG00000173599 E034 0.0000000       11 66855096 66855133 38 -      
ENSG00000173599 E035 0.9998973 0.0172671820 7.838552e-01   11 66856146 66856270 125 - 0.331 0.280 -0.335
ENSG00000173599 E036 3.7765058 0.1954452078 6.906471e-01 0.8294836743 11 66856419 66857882 1464 - 0.707 0.581 -0.540
ENSG00000173599 E037 1.0405957 0.0865521205 1.201771e-01   11 66857883 66858269 387 - 0.000 0.353 11.718
ENSG00000173599 E038 0.7677130 0.0175557746 2.029488e-01   11 66858270 66858335 66 - 0.000 0.281 11.784
ENSG00000173599 E039 0.6368449 0.0189647996 2.962581e-01   11 66858336 66858356 21 - 0.000 0.237 11.458
ENSG00000173599 E040 5.6320681 0.1540436514 3.722316e-01 0.6057905650 11 66858357 66860262 1906 - 0.896 0.706 -0.751
ENSG00000173599 E041 1.0237200 0.0194438067 6.537728e-01   11 66860263 66860429 167 - 0.196 0.282 0.676
ENSG00000173599 E042 0.3032425 0.0274424043 7.519460e-01   11 66860430 66860447 18 - 0.000 0.135 10.387
ENSG00000173599 E043 2.4055527 0.0088151664 7.580833e-02 0.2363849555 11 66860448 66860669 222 - 0.196 0.550 2.155
ENSG00000173599 E044 136.5487767 0.0011977328 4.418833e-01 0.6600165419 11 66863774 66863956 183 - 2.097 2.067 -0.100
ENSG00000173599 E045 127.6929572 0.0015353880 8.750084e-01 0.9387216929 11 66866187 66866349 163 - 2.051 2.044 -0.022
ENSG00000173599 E046 106.7151650 0.0066033941 1.179777e-01 0.3125295117 11 66868846 66868964 119 - 2.033 1.942 -0.307
ENSG00000173599 E047 116.2611452 0.0004319785 4.525823e-03 0.0320766598 11 66870302 66870453 152 - 2.083 1.978 -0.354
ENSG00000173599 E048 106.7702014 0.0008092778 2.570267e-02 0.1143872962 11 66870775 66870892 118 - 2.033 1.941 -0.307
ENSG00000173599 E049 118.6595228 0.0005086573 6.594756e-02 0.2160534344 11 66871052 66871197 146 - 2.064 1.993 -0.237
ENSG00000173599 E050 124.8890800 0.0004370088 3.635910e-01 0.5986921359 11 66871315 66871480 166 - 2.060 2.024 -0.119
ENSG00000173599 E051 106.4809055 0.0004987104 1.606727e-01 0.3777905692 11 66871687 66871801 115 - 2.007 1.950 -0.191
ENSG00000173599 E052 83.7274942 0.0069012309 2.730126e-02 0.1191872061 11 66871802 66871871 70 - 1.960 1.824 -0.456
ENSG00000173599 E053 101.6004616 0.0011540023 4.536775e-03 0.0321328231 11 66872024 66872159 136 - 2.035 1.918 -0.396
ENSG00000173599 E054 1.0410960 0.0794686196 2.184360e-01   11 66907821 66907901 81 - 0.433 0.191 -1.628
ENSG00000173599 E055 0.4762370 0.0217681645 7.084946e-01   11 66948088 66948203 116 - 0.196 0.135 -0.650
ENSG00000173599 E056 0.2027342 0.0369252677 1.000000e+00   11 66948358 66948449 92 - 0.000 0.073 9.309
ENSG00000173599 E057 0.7254668 0.1666326296 1.000000e+00   11 66949957 66950707 751 - 0.197 0.192 -0.047
ENSG00000173599 E058 0.7802874 0.0173849833 9.335482e-02   11 66952296 66952429 134 - 0.433 0.135 -2.234
ENSG00000173599 E059 50.3875359 0.0008538479 4.911235e-01 0.6947437162 11 66952430 66952464 35 - 1.680 1.640 -0.135
ENSG00000173599 E060 34.8256628 0.0042020845 4.655881e-01 0.6770131713 11 66952465 66952468 4 - 1.534 1.479 -0.186
ENSG00000173599 E061 9.3769161 0.1403424493 1.929060e-01 0.4206822861 11 66954249 66954436 188 - 1.157 0.884 -1.002
ENSG00000173599 E062 0.1723744 0.0448850604 1.000000e+00   11 66957300 66957614 315 - 0.000 0.073 9.239
ENSG00000173599 E063 3.3185748 0.0378499300 7.269794e-01 0.8524057899 11 66957740 66957868 129 - 0.646 0.588 -0.257
ENSG00000173599 E064 3.6831573 0.0123024720 5.727845e-01 0.7522407611 11 66957869 66957996 128 - 0.699 0.611 -0.377
ENSG00000173599 E065 33.7229759 0.0011897928 4.599915e-01 0.6731333899 11 66958322 66958397 76 - 1.519 1.468 -0.176