ENSG00000173511

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309422 ENSG00000173511 HEK293_OSMI2_6hA HEK293_TMG_6hB VEGFB protein_coding protein_coding 31.0811 44.44653 11.63259 10.59613 0.2849253 -1.932983 17.9260344 28.254984 6.3822730 8.7344074 0.4239941 -2.1446149 0.55295833 0.6042000 0.54763333 -0.05656667 8.600791e-01 1.481284e-12 FALSE  
ENST00000426086 ENSG00000173511 HEK293_OSMI2_6hA HEK293_TMG_6hB VEGFB protein_coding protein_coding 31.0811 44.44653 11.63259 10.59613 0.2849253 -1.932983 5.3424072 6.873071 1.3188772 1.3315827 0.1635318 -2.3728446 0.16714583 0.1596667 0.11406667 -0.04560000 5.421006e-01 1.481284e-12 FALSE  
ENST00000541681 ENSG00000173511 HEK293_OSMI2_6hA HEK293_TMG_6hB VEGFB protein_coding protein_coding 31.0811 44.44653 11.63259 10.59613 0.2849253 -1.932983 0.3230393 0.000000 0.7750499 0.0000000 0.2117073 6.2947124 0.01801250 0.0000000 0.06583333 0.06583333 1.481284e-12 1.481284e-12    
ENST00000543462 ENSG00000173511 HEK293_OSMI2_6hA HEK293_TMG_6hB VEGFB protein_coding retained_intron 31.0811 44.44653 11.63259 10.59613 0.2849253 -1.932983 1.9498913 1.987305 1.3777605 0.4623564 0.2034283 -0.5252963 0.07059167 0.0490000 0.11866667 0.06966667 1.726890e-01 1.481284e-12    
MSTRG.5661.4 ENSG00000173511 HEK293_OSMI2_6hA HEK293_TMG_6hB VEGFB protein_coding   31.0811 44.44653 11.63259 10.59613 0.2849253 -1.932983 2.6882207 3.810466 0.7523226 1.0098412 0.4471958 -2.3252752 0.08605417 0.0840000 0.06510000 -0.01890000 8.368564e-01 1.481284e-12 FALSE  
MSTRG.5661.6 ENSG00000173511 HEK293_OSMI2_6hA HEK293_TMG_6hB VEGFB protein_coding   31.0811 44.44653 11.63259 10.59613 0.2849253 -1.932983 1.3026948 2.001306 0.7281797 1.1806504 0.4274008 -1.4460884 0.05653750 0.0695000 0.06250000 -0.00700000 1.000000e+00 1.481284e-12 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000173511 E001 1.8807950 0.0104231748 4.577938e-01 6.716168e-01 11 64234584 64234719 136 + 0.243 0.402 1.024
ENSG00000173511 E002 0.9400874 0.0166817628 3.354533e-01   11 64234720 64234752 33 + 0.001 0.263 8.571
ENSG00000173511 E003 1.4051781 0.0144568606 7.108097e-01 8.423648e-01 11 64234753 64234768 16 + 0.243 0.324 0.564
ENSG00000173511 E004 58.2106170 0.0010186759 3.566342e-02 1.433586e-01 11 64234769 64234893 125 + 1.522 1.662 0.478
ENSG00000173511 E005 0.7850890 0.0177249314 1.929651e-01   11 64235232 64235302 71 + 0.398 0.151 -1.851
ENSG00000173511 E006 102.2898257 0.0022357415 8.096632e-01 9.019551e-01 11 64235458 64235500 43 + 1.868 1.878 0.031
ENSG00000173511 E007 212.4749781 0.0002838802 3.829138e-01 6.146564e-01 11 64235813 64235910 98 + 2.173 2.199 0.087
ENSG00000173511 E008 262.0108427 0.0002901170 8.200246e-01 9.080737e-01 11 64235911 64236009 99 + 2.292 2.283 -0.030
ENSG00000173511 E009 6.1209764 0.1954837609 4.055709e-01 6.327132e-01 11 64236010 64236020 11 + 0.890 0.699 -0.759
ENSG00000173511 E010 275.8688618 0.0002054973 1.396216e-01 3.469102e-01 11 64236254 64236327 74 + 2.344 2.302 -0.141
ENSG00000173511 E011 13.9811594 0.0562198968 7.091331e-03 4.503463e-02 11 64237127 64237186 60 + 1.369 0.952 -1.494
ENSG00000173511 E012 196.6322398 0.0003048958 5.610072e-01 7.440367e-01 11 64237187 64237222 36 + 2.181 2.160 -0.070
ENSG00000173511 E013 226.9875849 0.0003536999 3.272084e-01 5.663177e-01 11 64237420 64237520 101 + 2.200 2.230 0.099
ENSG00000173511 E014 173.7137135 0.0003212053 5.936600e-02 2.013783e-01 11 64237521 64237535 15 + 2.052 2.120 0.227
ENSG00000173511 E015 365.4026736 0.0001848973 4.357789e-02 1.640719e-01 11 64237536 64237655 120 + 2.390 2.437 0.156
ENSG00000173511 E016 2.3544250 0.0098142924 1.117854e-06 3.127467e-05 11 64237797 64237901 105 + 0.966 0.192 -3.895
ENSG00000173511 E017 660.5423571 0.0004318122 1.078381e-01 2.954725e-01 11 64238356 64239264 909 + 2.712 2.677 -0.117