ENSG00000173273

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310430 ENSG00000173273 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS protein_coding protein_coding 6.280512 5.603305 9.909342 1.732795 0.3925656 0.8213939 4.2765779 2.9153237 7.9744579 0.7495502 0.5484244 1.448598 0.6329542 0.547633333 0.80280000 0.2551667 1.010195e-02 1.604429e-07 FALSE TRUE
ENST00000517770 ENSG00000173273 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS protein_coding protein_coding 6.280512 5.603305 9.909342 1.732795 0.3925656 0.8213939 1.3983727 2.6008638 0.3378402 1.0252830 0.1749992 -2.908031 0.2856208 0.435366667 0.03276667 -0.4026000 7.693725e-03 1.604429e-07   FALSE
MSTRG.31097.5 ENSG00000173273 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS protein_coding   6.280512 5.603305 9.909342 1.732795 0.3925656 0.8213939 0.4759841 0.0130553 1.3802306 0.0130553 0.1549659 5.914082 0.0583625 0.002066667 0.14086667 0.1388000 1.604429e-07 1.604429e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000173273 E001 0.0000000       8 9555775 9555911 137 +      
ENSG00000173273 E002 0.0000000       8 9555912 9555913 2 +      
ENSG00000173273 E003 1.5601422 0.314497535 0.7930347109 0.892216270 8 9555914 9555931 18 + 0.344 0.483 0.756
ENSG00000173273 E004 21.4566439 0.401073935 0.3329775443 0.571594229 8 9555932 9556236 305 + 1.195 1.513 1.110
ENSG00000173273 E005 45.8505940 0.054807598 0.4079537145 0.634419916 8 9556237 9556612 376 + 1.618 1.674 0.190
ENSG00000173273 E006 1.8575174 0.161388248 0.0504859656 0.180806436 8 9556613 9558831 2219 + 0.209 0.710 2.738
ENSG00000173273 E007 0.0000000       8 9566260 9566526 267 +      
ENSG00000173273 E008 0.0000000       8 9575007 9575399 393 +      
ENSG00000173273 E009 53.7854830 0.027658910 0.0018252274 0.015879385 8 9580159 9580383 225 + 1.723 1.633 -0.304
ENSG00000173273 E010 0.0000000       8 9615290 9615486 197 +      
ENSG00000173273 E011 40.2863236 0.024940327 0.0059194001 0.039341354 8 9615582 9615677 96 + 1.596 1.519 -0.265
ENSG00000173273 E012 0.0000000       8 9670119 9670196 78 +      
ENSG00000173273 E013 0.0000000       8 9670727 9670789 63 +      
ENSG00000173273 E014 0.0000000       8 9670980 9671056 77 +      
ENSG00000173273 E015 0.0000000       8 9671146 9671203 58 +      
ENSG00000173273 E016 0.0000000       8 9679754 9679836 83 +      
ENSG00000173273 E017 0.1779838 0.111585645 0.7977513804   8 9679846 9679950 105 + 0.081 0.000 -18.918
ENSG00000173273 E018 29.7727866 0.027952539 0.0186028229 0.091066508 8 9679951 9679987 37 + 1.465 1.398 -0.232
ENSG00000173273 E019 34.9420137 0.033518016 0.0042440616 0.030515232 8 9680725 9680800 76 + 1.549 1.422 -0.436
ENSG00000173273 E020 0.0000000       8 9680801 9681156 356 +      
ENSG00000173273 E021 39.0403540 0.038882422 0.0100915838 0.058544838 8 9704663 9704757 95 + 1.588 1.493 -0.325
ENSG00000173273 E022 27.1494345 0.028933849 0.2327065099 0.468285146 8 9706187 9706253 67 + 1.390 1.449 0.204
ENSG00000173273 E023 42.0407076 0.033213941 0.0181125709 0.089406206 8 9706811 9706997 187 + 1.611 1.549 -0.212
ENSG00000173273 E024 0.0000000       8 9706998 9707008 11 +      
ENSG00000173273 E025 32.6222199 0.029425824 0.0005187608 0.005844891 8 9708371 9708492 122 + 1.534 1.354 -0.619
ENSG00000173273 E026 33.8175115 0.011888050 0.0009928285 0.009856490 8 9709955 9710046 92 + 1.529 1.437 -0.317
ENSG00000173273 E027 31.3580070 0.024571848 0.0179581444 0.088899751 8 9710142 9710220 79 + 1.487 1.435 -0.179
ENSG00000173273 E028 0.1308682 0.030601268 0.2989553143   8 9710221 9710409 189 + 0.000 0.178 21.502
ENSG00000173273 E029 34.6752125 0.017796929 0.0186934042 0.091371502 8 9720374 9720455 82 + 1.520 1.486 -0.118
ENSG00000173273 E030 36.3910613 0.018970790 0.0081271140 0.049908544 8 9720456 9720545 90 + 1.549 1.485 -0.219
ENSG00000173273 E031 0.0000000       8 9722398 9722500 103 +      
ENSG00000173273 E032 33.4655938 0.037259627 0.1737919985 0.395594942 8 9726641 9726720 80 + 1.488 1.513 0.086
ENSG00000173273 E033 42.0444620 0.020288758 0.0955806192 0.274065233 8 9730890 9731035 146 + 1.582 1.616 0.117
ENSG00000173273 E034 52.5547127 0.006224961 0.0004721683 0.005422671 8 9733279 9733444 166 + 1.703 1.659 -0.147
ENSG00000173273 E035 52.7539296 0.033989529 0.0095937267 0.056369213 8 9734865 9734990 126 + 1.710 1.638 -0.245
ENSG00000173273 E036 38.9261527 0.028778416 0.0083501737 0.050924784 8 9734991 9735084 94 + 1.582 1.504 -0.266
ENSG00000173273 E037 41.2118114 0.030160542 0.0419572730 0.159831072 8 9735377 9735486 110 + 1.592 1.568 -0.082
ENSG00000173273 E038 0.0000000       8 9740914 9741115 202 +      
ENSG00000173273 E039 0.0000000       8 9743464 9743572 109 +      
ENSG00000173273 E040 51.9705076 0.038349071 0.1514268401 0.364409223 8 9748024 9748212 189 + 1.673 1.704 0.104
ENSG00000173273 E041 0.0000000       8 9748213 9748213 1 +      
ENSG00000173273 E042 57.2618207 0.019971942 0.0947927054 0.272597650 8 9751609 9751846 238 + 1.713 1.751 0.129
ENSG00000173273 E043 46.6253855 0.018483321 0.0060640194 0.040050168 8 9752544 9752626 83 + 1.652 1.599 -0.181
ENSG00000173273 E044 60.4529412 0.020279179 0.0006569716 0.007069376 8 9761516 9761636 121 + 1.777 1.674 -0.348
ENSG00000173273 E045 60.3155347 0.026520791 0.0084257875 0.051271768 8 9763147 9763244 98 + 1.765 1.706 -0.199
ENSG00000173273 E046 50.7537119 0.042586631 0.1864777383 0.412410910 8 9764716 9764790 75 + 1.667 1.695 0.097
ENSG00000173273 E047 57.6343212 0.023944316 0.4350959977 0.655047053 8 9765692 9765797 106 + 1.692 1.807 0.388
ENSG00000173273 E048 71.0038941 0.007101878 0.1267651441 0.326651449 8 9766239 9766425 187 + 1.789 1.881 0.312
ENSG00000173273 E049 27.3984239 0.001437842 0.8124508695 0.903667411 8 9770106 9770130 25 + 1.352 1.539 0.645
ENSG00000173273 E050 50.4980440 0.001068168 0.5890679255 0.763018184 8 9770131 9770262 132 + 1.630 1.774 0.489
ENSG00000173273 E051 3.9116031 0.006760967 0.8778159642 0.940120209 8 9772369 9772423 55 + 0.630 0.746 0.485
ENSG00000173273 E052 827.6868005 1.466512582 0.2910346139 0.531610623 8 9776650 9782346 5697 + 2.689 3.145 1.517