ENSG00000173120

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000524657 ENSG00000173120 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM2A protein_coding processed_transcript 26.87608 36.26058 23.99904 2.189616 0.9103785 -0.5952221 4.6489092 4.796565 2.199630 0.7275524 0.3352460 -1.1212015 0.16290417 0.1343333 0.09203333 -0.042300000 7.106180e-01 2.901935e-22 FALSE TRUE
ENST00000525041 ENSG00000173120 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM2A protein_coding processed_transcript 26.87608 36.26058 23.99904 2.189616 0.9103785 -0.5952221 0.3945759 0.000000 1.632444 0.0000000 0.8164385 7.3597002 0.01672083 0.0000000 0.06643333 0.066433333 2.471246e-01 2.901935e-22 FALSE FALSE
ENST00000529006 ENSG00000173120 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM2A protein_coding protein_coding 26.87608 36.26058 23.99904 2.189616 0.9103785 -0.5952221 3.4901251 4.086412 3.204805 0.5458773 0.4033956 -0.3496293 0.13792500 0.1118333 0.13510000 0.023266667 8.593162e-01 2.901935e-22 FALSE TRUE
ENST00000530342 ENSG00000173120 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM2A protein_coding protein_coding 26.87608 36.26058 23.99904 2.189616 0.9103785 -0.5952221 5.3794249 7.214831 4.572799 1.2908239 0.2572972 -0.6567346 0.19901250 0.1959333 0.19126667 -0.004666667 1.000000e+00 2.901935e-22 FALSE TRUE
ENST00000531696 ENSG00000173120 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM2A protein_coding processed_transcript 26.87608 36.26058 23.99904 2.189616 0.9103785 -0.5952221 1.9570125 5.287215 0.000000 0.7720456 0.0000000 -9.0490903 0.06132083 0.1451000 0.00000000 -0.145100000 2.901935e-22 2.901935e-22 FALSE TRUE
MSTRG.5793.2 ENSG00000173120 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM2A protein_coding   26.87608 36.26058 23.99904 2.189616 0.9103785 -0.5952221 7.2495740 9.607397 8.407648 1.7958588 0.2735358 -0.1922292 0.27992083 0.2613333 0.35203333 0.090700000 5.465188e-01 2.901935e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000173120 E001 1.5587868 0.0119588101 3.135612e-01 5.537713e-01 11 67119097 67119114 18 + 0.497 0.345 -0.817
ENSG00000173120 E002 1.5282393 0.0163208060 7.035394e-01 8.378806e-01 11 67119115 67119122 8 + 0.433 0.390 -0.235
ENSG00000173120 E003 1.8620294 0.0137237360 5.973957e-01 7.685954e-01 11 67119123 67119156 34 + 0.497 0.431 -0.333
ENSG00000173120 E004 4.7408686 0.0717064521 1.506832e-01 3.632726e-01 11 67119263 67119268 6 + 0.549 0.842 1.227
ENSG00000173120 E005 37.4778375 0.0037516437 5.377874e-01 7.275156e-01 11 67119269 67119690 422 + 1.572 1.570 -0.009
ENSG00000173120 E006 30.7367778 0.0011953782 6.009820e-01 7.708386e-01 11 67119691 67119869 179 + 1.485 1.487 0.007
ENSG00000173120 E007 35.6977248 0.0011350223 2.250622e-01 4.595145e-01 11 67119870 67119890 21 + 1.572 1.535 -0.127
ENSG00000173120 E008 67.5499805 0.0106449520 4.667727e-01 6.778645e-01 11 67119891 67119975 85 + 1.825 1.814 -0.036
ENSG00000173120 E009 84.4101532 0.0124772831 1.975950e-01 4.266024e-01 11 67119976 67120049 74 + 1.945 1.894 -0.171
ENSG00000173120 E010 64.2824942 0.0104151033 9.600667e-02 2.747441e-01 11 67121234 67121268 35 + 1.841 1.767 -0.250
ENSG00000173120 E011 104.3805320 0.0005099414 6.980888e-02 2.244169e-01 11 67121269 67121358 90 + 2.023 1.994 -0.098
ENSG00000173120 E012 11.7964882 0.0028972162 4.823287e-01 6.885956e-01 11 67131952 67132073 122 + 1.113 1.077 -0.130
ENSG00000173120 E013 0.5177432 0.0229224257 1.000000e+00   11 67143204 67143371 168 + 0.155 0.173 0.191
ENSG00000173120 E014 1.9456619 0.0103606348 2.738779e-01 5.138154e-01 11 67149055 67149207 153 + 0.552 0.391 -0.814
ENSG00000173120 E015 124.9859215 0.0004196450 9.323820e-05 1.410349e-03 11 67180079 67180217 139 + 2.137 2.044 -0.310
ENSG00000173120 E016 1.0232875 0.9170163388 8.720579e-01   11 67180218 67180453 236 + 0.155 0.356 1.561
ENSG00000173120 E017 96.5854509 0.0050466385 6.994151e-04 7.440288e-03 11 67181320 67181398 79 + 2.048 1.915 -0.444
ENSG00000173120 E018 85.6463162 0.0009044493 4.335606e-04 5.064908e-03 11 67181846 67181892 47 + 1.982 1.875 -0.359
ENSG00000173120 E019 99.4438535 0.0074162043 2.411531e-04 3.122396e-03 11 67207510 67207567 58 + 2.078 1.915 -0.546
ENSG00000173120 E020 94.4607074 0.0008928128 8.871465e-05 1.351919e-03 11 67207568 67207601 34 + 2.030 1.914 -0.389
ENSG00000173120 E021 125.0618537 0.0005460437 8.889796e-06 1.895645e-04 11 67207602 67207688 87 + 2.149 2.038 -0.373
ENSG00000173120 E022 135.3247279 0.0003542237 9.161405e-06 1.944772e-04 11 67215340 67215446 107 + 2.179 2.076 -0.345
ENSG00000173120 E023 0.2852693 0.2771424030 1.219205e-01   11 67215447 67215673 227 + 0.265 0.000 -12.053
ENSG00000173120 E024 102.0061457 0.0003884144 4.360641e-02 1.641574e-01 11 67215856 67215910 55 + 2.019 1.983 -0.122
ENSG00000173120 E025 85.2172817 0.0004329590 1.090102e-02 6.194764e-02 11 67215911 67215949 39 + 1.958 1.894 -0.215
ENSG00000173120 E026 0.7491197 0.0187147895 4.905618e-01   11 67217543 67217730 188 + 0.155 0.295 1.185
ENSG00000173120 E027 82.3941124 0.0005599018 3.389057e-02 1.385641e-01 11 67217731 67217755 25 + 1.935 1.886 -0.166
ENSG00000173120 E028 167.8737758 0.0024143700 1.802112e-02 8.910523e-02 11 67217756 67217884 129 + 2.241 2.193 -0.161
ENSG00000173120 E029 142.9473113 0.0003377348 3.201525e-01 5.598834e-01 11 67219288 67219403 116 + 2.137 2.143 0.020
ENSG00000173120 E030 0.7389688 0.0185917250 3.905918e-02   11 67219404 67219688 285 + 0.433 0.094 -2.814
ENSG00000173120 E031 136.2973037 0.0003350483 7.252284e-01 8.512729e-01 11 67228037 67228163 127 + 2.104 2.130 0.087
ENSG00000173120 E032 189.7057726 0.0002758351 3.470320e-01 5.845584e-01 11 67231566 67231764 199 + 2.220 2.283 0.210
ENSG00000173120 E033 170.9454088 0.0002885578 2.464033e-01 4.840420e-01 11 67231765 67231960 196 + 2.171 2.242 0.237
ENSG00000173120 E034 40.2009827 0.0010648686 2.248456e-02 1.041769e-01 11 67240047 67240300 254 + 1.658 1.565 -0.317
ENSG00000173120 E035 34.4110293 0.0028174488 7.991395e-03 4.926929e-02 11 67240301 67240369 69 + 1.615 1.483 -0.452
ENSG00000173120 E036 145.2291578 0.0003799738 1.201215e-01 3.160445e-01 11 67243009 67243092 84 + 2.153 2.141 -0.038
ENSG00000173120 E037 0.7616940 0.0643685635 4.930445e-02   11 67243507 67243816 310 + 0.431 0.095 -2.803
ENSG00000173120 E038 0.3228314 0.3935500363 1.421763e-01   11 67245078 67245188 111 + 0.269 0.000 -11.966
ENSG00000173120 E039 325.0768687 0.0008276430 2.211508e-03 1.847092e-02 11 67245189 67245458 270 + 2.517 2.482 -0.118
ENSG00000173120 E040 12.2441250 0.1299770521 8.102816e-02 2.468684e-01 11 67245539 67245984 446 + 1.255 0.985 -0.970
ENSG00000173120 E041 234.8478745 0.0022562321 7.037545e-02 2.254805e-01 11 67245985 67246116 132 + 2.367 2.346 -0.071
ENSG00000173120 E042 190.0322134 0.0028917873 1.695575e-01 3.899268e-01 11 67248281 67248370 90 + 2.270 2.257 -0.045
ENSG00000173120 E043 0.9073990 0.7426775887 4.714960e-01   11 67248371 67248379 9 + 0.435 0.163 -1.924
ENSG00000173120 E044 2.1628665 0.9414983181 5.109573e-01 7.086925e-01 11 67248545 67248605 61 + 0.494 0.483 -0.054
ENSG00000173120 E045 246.1316216 0.0011492947 8.308304e-01 9.142601e-01 11 67250086 67250346 261 + 2.349 2.392 0.144
ENSG00000173120 E046 332.4987523 0.0143536078 2.343920e-01 4.701489e-01 11 67250347 67250798 452 + 2.438 2.539 0.335
ENSG00000173120 E047 22.2796532 0.5408468565 8.311598e-01 9.144508e-01 11 67252338 67252693 356 + 1.345 1.352 0.025
ENSG00000173120 E048 227.9219206 1.3535202830 5.004164e-01 7.010345e-01 11 67252694 67252857 164 + 2.202 2.403 0.672
ENSG00000173120 E049 222.8665604 1.3248163311 4.644915e-01 6.762433e-01 11 67253453 67253611 159 + 2.167 2.402 0.786
ENSG00000173120 E050 325.3982884 0.0126826949 2.863375e-01 5.270042e-01 11 67254203 67254418 216 + 2.436 2.526 0.301
ENSG00000173120 E051 2466.6046975 0.0008101053 9.489279e-09 4.486353e-07 11 67254874 67258082 3209 + 3.305 3.407 0.340