ENSG00000172943

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338154 ENSG00000172943 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF8 protein_coding protein_coding 28.96783 37.26389 23.20546 3.023875 0.3799344 -0.6830791 3.124879 3.1654446 5.244902 1.7579290 0.8371653 0.7267053 0.11541250 0.078133333 0.2259667 0.14783333 6.777827e-01 7.343655e-28 FALSE TRUE
ENST00000338946 ENSG00000172943 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF8 protein_coding protein_coding 28.96783 37.26389 23.20546 3.023875 0.3799344 -0.6830791 8.495179 12.4962224 7.057860 1.5221571 0.6575958 -0.8233008 0.29762917 0.333333333 0.3041000 -0.02923333 8.768562e-01 7.343655e-28 FALSE TRUE
ENST00000396282 ENSG00000172943 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF8 protein_coding protein_coding 28.96783 37.26389 23.20546 3.023875 0.3799344 -0.6830791 1.329489 0.3510267 3.220370 0.3510267 0.7777846 3.1615222 0.05590833 0.008333333 0.1390333 0.13070000 6.184642e-02 7.343655e-28 FALSE TRUE
ENST00000687283 ENSG00000172943 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF8 protein_coding retained_intron 28.96783 37.26389 23.20546 3.023875 0.3799344 -0.6830791 2.924471 2.8377446 0.000000 0.6060675 0.0000000 -8.1536760 0.08514167 0.076566667 0.0000000 -0.07656667 5.582189e-12 7.343655e-28 FALSE TRUE
ENST00000691629 ENSG00000172943 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF8 protein_coding processed_transcript 28.96783 37.26389 23.20546 3.023875 0.3799344 -0.6830791 2.365897 5.1374717 0.000000 0.5967328 0.0000000 -9.0077202 0.06905000 0.137100000 0.0000000 -0.13710000 7.343655e-28 7.343655e-28 FALSE TRUE
MSTRG.34303.12 ENSG00000172943 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF8 protein_coding   28.96783 37.26389 23.20546 3.023875 0.3799344 -0.6830791 6.076134 9.9103014 4.044664 0.4044213 1.1943039 -1.2908015 0.21353750 0.269866667 0.1740000 -0.09586667 6.025686e-01 7.343655e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172943 E001 1.3935993 0.0213072133 1.511809e-01 3.640415e-01 X 53936676 53936679 4 - 0.156 0.466 2.161
ENSG00000172943 E002 2.7695150 0.0202499827 1.075784e-02 6.135540e-02 X 53936680 53936693 14 - 0.156 0.687 3.165
ENSG00000172943 E003 5.5115710 0.1414186387 2.023847e-01 4.326431e-01 X 53936694 53936704 11 - 0.554 0.883 1.362
ENSG00000172943 E004 128.1305662 0.6299328443 1.349262e-01 3.395711e-01 X 53936705 53936910 206 - 1.728 2.210 1.618
ENSG00000172943 E005 61.5216740 0.3934902952 1.037133e-01 2.883926e-01 X 53936911 53936913 3 - 1.442 1.889 1.522
ENSG00000172943 E006 100.4358744 0.5448822240 1.208629e-01 3.172132e-01 X 53936914 53936951 38 - 1.624 2.105 1.620
ENSG00000172943 E007 551.5615219 1.4921888385 3.876768e-01 6.186409e-01 X 53936952 53937497 546 - 2.456 2.821 1.214
ENSG00000172943 E008 263.3003031 1.2454842005 3.764767e-01 6.094179e-01 X 53937498 53937648 151 - 2.160 2.494 1.118
ENSG00000172943 E009 444.4987771 1.4422781183 4.167718e-01 6.412045e-01 X 53937649 53938059 411 - 2.395 2.719 1.078
ENSG00000172943 E010 610.2694811 1.5877640621 4.855654e-01 6.909613e-01 X 53938060 53939161 1102 - 2.575 2.845 0.899
ENSG00000172943 E011 160.8619146 1.1059678185 4.150015e-01 6.398013e-01 X 53939162 53939246 85 - 1.997 2.268 0.908
ENSG00000172943 E012 245.6365564 0.0056876723 2.136811e-01 4.459899e-01 X 53940180 53940368 189 - 2.287 2.415 0.427
ENSG00000172943 E013 210.8388127 0.0055847179 7.743722e-01 8.813853e-01 X 53940369 53940516 148 - 2.243 2.336 0.312
ENSG00000172943 E014 1.6785765 0.0121989077 2.220523e-03 1.852643e-02 X 53942618 53943255 638 - 0.648 0.171 -2.833
ENSG00000172943 E015 0.9169527 0.0155518800 1.064862e-02   X 53943256 53943402 147 - 0.499 0.094 -3.157
ENSG00000172943 E016 151.0362777 0.0004511903 6.771678e-01 8.209207e-01 X 53944134 53944243 110 - 2.104 2.192 0.292
ENSG00000172943 E017 0.4756169 0.0308728172 2.790761e-01   X 53944244 53944564 321 - 0.000 0.237 10.957
ENSG00000172943 E018 145.1908076 0.0012833225 8.034708e-01 8.982988e-01 X 53962844 53962939 96 - 2.088 2.173 0.283
ENSG00000172943 E019 0.3088520 0.0287135244 5.808711e-01   X 53962940 53963049 110 - 0.156 0.094 -0.838
ENSG00000172943 E020 335.6321265 0.0034423748 7.662959e-01 8.763740e-01 X 53984914 53985227 314 - 2.459 2.530 0.236
ENSG00000172943 E021 37.1686553 0.2022701440 1.911127e-01 4.183220e-01 X 53985228 53985744 517 - 1.611 1.534 -0.265
ENSG00000172943 E022 11.8758136 0.2585292297 3.239275e-01 5.632497e-01 X 53985745 53985784 40 - 1.138 1.063 -0.271
ENSG00000172943 E023 9.4856299 0.3329554261 2.685342e-01 5.081996e-01 X 53985785 53985815 31 - 1.043 0.977 -0.241
ENSG00000172943 E024 191.2239722 0.0017525656 9.130669e-01 9.586266e-01 X 53985816 53985906 91 - 2.212 2.285 0.245
ENSG00000172943 E025 165.1789020 0.0041212496 3.470270e-01 5.845558e-01 X 53985907 53985949 43 - 2.171 2.213 0.138
ENSG00000172943 E026 199.5480054 0.0013270065 3.247558e-01 5.640135e-01 X 53987078 53987163 86 - 2.250 2.297 0.154
ENSG00000172943 E027 146.1836350 0.0033314841 9.103110e-02 2.655577e-01 X 53987766 53987786 21 - 2.141 2.151 0.030
ENSG00000172943 E028 317.4358745 0.0099598357 1.153959e-01 3.081456e-01 X 53987787 53987944 158 - 2.482 2.483 0.006
ENSG00000172943 E029 219.6644198 0.0125097273 1.265441e-01 3.263343e-01 X 53992736 53992793 58 - 2.328 2.320 -0.025
ENSG00000172943 E030 157.9083481 0.0156201009 7.157677e-02 2.279875e-01 X 53992794 53992801 8 - 2.206 2.166 -0.132
ENSG00000172943 E031 180.5951218 0.0091442650 4.026975e-01 6.305185e-01 X 53992802 53992839 38 - 2.214 2.251 0.125
ENSG00000172943 E032 1.7790847 0.0115222682 6.800933e-03 4.369962e-02 X 53992840 53993009 170 - 0.648 0.237 -2.250
ENSG00000172943 E033 278.3839939 0.0076577996 8.816041e-02 2.603089e-01 X 53993601 53993903 303 - 2.424 2.426 0.007
ENSG00000172943 E034 1.6883674 0.3700123011 1.290825e-01 3.303377e-01 X 53995131 53995205 75 - 0.617 0.236 -2.121
ENSG00000172943 E035 191.2204153 0.0024536158 1.218445e-02 6.720718e-02 X 53995693 53995782 90 - 2.268 2.258 -0.033
ENSG00000172943 E036 0.0000000       X 53998155 53998286 132 -      
ENSG00000172943 E037 1.0183708 0.0153787590 3.720066e-01   X 53999487 53999869 383 - 0.360 0.237 -0.832
ENSG00000172943 E038 166.8111579 0.0071950428 2.658206e-01 5.052485e-01 X 53999870 53999961 92 - 2.184 2.213 0.096
ENSG00000172943 E039 188.5111398 0.0045315218 5.896027e-02 2.004246e-01 X 54002155 54002261 107 - 2.256 2.258 0.006
ENSG00000172943 E040 178.0461855 0.0075734940 3.086829e-01 5.492324e-01 X 54002595 54002682 88 - 2.212 2.243 0.103
ENSG00000172943 E041 257.6951543 0.0061098166 6.305877e-03 4.123063e-02 X 54011122 54011284 163 - 2.415 2.378 -0.121
ENSG00000172943 E042 279.1687187 0.0065102940 1.171939e-04 1.705564e-03 X 54014377 54014563 187 - 2.479 2.394 -0.284
ENSG00000172943 E043 224.7183512 0.0049303259 2.014693e-05 3.842988e-04 X 54016595 54016736 142 - 2.391 2.297 -0.314
ENSG00000172943 E044 136.6849872 0.0103915762 8.338574e-04 8.555868e-03 X 54017661 54017736 76 - 2.188 2.075 -0.377
ENSG00000172943 E045 109.6982250 0.0046465958 6.233556e-06 1.393473e-04 X 54017737 54017769 33 - 2.105 1.971 -0.449
ENSG00000172943 E046 74.1579736 0.0026791148 8.317263e-05 1.282682e-03 X 54017770 54017770 1 - 1.923 1.810 -0.381
ENSG00000172943 E047 74.0442185 0.0044985894 5.961412e-04 6.546298e-03 X 54017771 54017778 8 - 1.916 1.814 -0.344
ENSG00000172943 E048 106.9247880 0.0004428883 1.474639e-06 3.987066e-05 X 54017779 54017821 43 - 2.072 1.974 -0.331
ENSG00000172943 E049 172.2156413 0.0043232517 7.501566e-04 7.862650e-03 X 54022259 54022367 109 - 2.255 2.194 -0.204
ENSG00000172943 E050 144.9209508 0.0015960568 4.461931e-05 7.553967e-04 X 54022758 54022843 86 - 2.186 2.117 -0.229
ENSG00000172943 E051 0.5421338 0.0231196511 2.257489e-01   X 54039630 54040072 443 - 0.270 0.094 -1.832
ENSG00000172943 E052 178.5237231 0.0107053154 1.358867e-02 7.272829e-02 X 54042631 54042809 179 - 2.273 2.213 -0.199
ENSG00000172943 E053 53.3510528 0.0115694888 1.937160e-01 4.217512e-01 X 54042810 54042820 11 - 1.728 1.712 -0.054
ENSG00000172943 E054 0.3337900 0.0288103054 5.852748e-01   X 54042821 54042836 16 - 0.156 0.094 -0.833
ENSG00000172943 E055 1.3273378 0.6545912170 6.175343e-01   X 54042837 54042907 71 - 0.358 0.353 -0.030
ENSG00000172943 E056 1.5053216 0.4550620831 4.067767e-01 6.335990e-01 X 54042908 54043057 150 - 0.436 0.352 -0.472
ENSG00000172943 E057 1.5178282 0.0246461814 6.165892e-01 7.814183e-01 X 54043058 54043110 53 - 0.435 0.388 -0.251
ENSG00000172943 E058 1.8625769 0.1401420331 9.230027e-01 9.638070e-01 X 54043111 54043194 84 - 0.433 0.465 0.165
ENSG00000172943 E059 77.0328353 0.0135253711 6.049621e-02 2.039312e-01 X 54043762 54043811 50 - 1.908 1.856 -0.176
ENSG00000172943 E060 126.8816932 0.0114387758 6.193892e-02 2.071580e-01 X 54043812 54044015 204 - 2.109 2.076 -0.110
ENSG00000172943 E061 107.3864171 0.0022997705 2.099355e-01 4.417610e-01 X 54044016 54044517 502 - 1.997 2.020 0.080
ENSG00000172943 E062 2.4516387 0.0089413976 5.300666e-01 7.221331e-01 X 54044875 54044949 75 - 0.554 0.502 -0.248
ENSG00000172943 E063 1.9754016 0.0139490670 4.978878e-01 6.994193e-01 X 54044950 54045249 300 - 0.499 0.430 -0.348
ENSG00000172943 E064 0.1779838 0.0412224334 2.299324e-01   X 54048905 54048958 54 - 0.156 0.000 -11.077