ENSG00000172845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310015 ENSG00000172845 HEK293_OSMI2_6hA HEK293_TMG_6hB SP3 protein_coding protein_coding 15.57732 2.901311 31.01209 0.5328919 1.027249 3.413555 1.007784 0.39575842 1.7082016 0.10037124 0.02112713 2.0822064 0.09722500 0.13256667 0.0552000 -0.07736667 0.01601152 0.01601152 FALSE TRUE
ENST00000416195 ENSG00000172845 HEK293_OSMI2_6hA HEK293_TMG_6hB SP3 protein_coding protein_coding 15.57732 2.901311 31.01209 0.5328919 1.027249 3.413555 7.965716 1.67081783 18.7232659 0.54419524 0.71356476 3.4783672 0.57453750 0.53750000 0.6037333 0.06623333 0.91213702 0.01601152 FALSE TRUE
ENST00000418194 ENSG00000172845 HEK293_OSMI2_6hA HEK293_TMG_6hB SP3 protein_coding protein_coding 15.57732 2.901311 31.01209 0.5328919 1.027249 3.413555 1.257551 0.46429809 0.3503109 0.23295126 0.35031091 -0.3965517 0.08329583 0.19810000 0.0120000 -0.18610000 0.42468826 0.01601152 FALSE TRUE
ENST00000652005 ENSG00000172845 HEK293_OSMI2_6hA HEK293_TMG_6hB SP3 protein_coding protein_coding 15.57732 2.901311 31.01209 0.5328919 1.027249 3.413555 1.022490 0.11685076 2.9120661 0.11685076 0.20812394 4.5257848 0.05159583 0.03333333 0.0939000 0.06056667 0.45165627 0.01601152 FALSE TRUE
MSTRG.19510.9 ENSG00000172845 HEK293_OSMI2_6hA HEK293_TMG_6hB SP3 protein_coding   15.57732 2.901311 31.01209 0.5328919 1.027249 3.413555 2.123013 0.04227548 4.0155088 0.04227548 1.07938480 6.2668930 0.07805417 0.02300000 0.1285000 0.10550000 0.20967884 0.01601152 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172845 E001 0.0000000       2 173880850 173880864 15 -      
ENSG00000172845 E002 0.6544085 0.0189360925 4.421821e-01   2 173880865 173881061 197 - 0.132 0.274 1.310
ENSG00000172845 E003 0.6709767 0.0434703434 4.437598e-01   2 173881525 173881690 166 - 0.132 0.274 1.309
ENSG00000172845 E004 0.1723744 0.0489485052 4.391171e-02   2 173881691 173881797 107 - 0.000 0.274 12.197
ENSG00000172845 E005 0.1614157 0.0337661646 7.457727e-01   2 173883276 173883488 213 - 0.049 0.000 -9.310
ENSG00000172845 E006 0.0000000       2 173897975 173898029 55 -      
ENSG00000172845 E007 0.0000000       2 173899391 173899428 38 -      
ENSG00000172845 E008 165.6457519 0.0012018105 1.021419e-18 2.535970e-16 2 173900775 173907559 6785 - 1.981 2.305 1.085
ENSG00000172845 E009 7.9876901 0.0624112581 5.285695e-01 7.210015e-01 2 173907560 173907588 29 - 0.799 0.657 -0.582
ENSG00000172845 E010 14.2327827 0.0076388970 8.432357e-01 9.212760e-01 2 173907589 173907825 237 - 1.001 1.029 0.104
ENSG00000172845 E011 4.0023383 0.0069802191 9.902333e-01 9.968394e-01 2 173907826 173907826 1 - 0.557 0.561 0.019
ENSG00000172845 E012 10.3057586 0.0155307452 2.645344e-01 5.037703e-01 2 173907827 173907885 59 - 0.863 1.027 0.615
ENSG00000172845 E013 8.7170215 0.0340328939 1.364167e-01 3.420163e-01 2 173907886 173907898 13 - 0.787 1.026 0.905
ENSG00000172845 E014 15.9980080 0.0074838333 9.075243e-02 2.651323e-01 2 173907899 173907965 67 - 1.026 1.225 0.717
ENSG00000172845 E015 25.1382679 0.0014433031 1.894143e-02 9.224542e-02 2 173907966 173908529 564 - 1.208 1.423 0.751
ENSG00000172845 E016 3.3423203 0.0112197802 7.489222e-01 8.660943e-01 2 173908530 173908531 2 - 0.496 0.561 0.308
ENSG00000172845 E017 9.0978621 0.0036782101 4.782412e-02 1.745950e-01 2 173908532 173908557 26 - 0.793 1.063 1.020
ENSG00000172845 E018 409.2026869 0.0035863599 1.112197e-01 3.009939e-01 2 173908558 173909944 1387 - 2.420 2.476 0.186
ENSG00000172845 E019 148.0166252 0.0003094229 5.812010e-01 7.579337e-01 2 173909945 173910164 220 - 1.984 2.009 0.084
ENSG00000172845 E020 104.4166005 0.0004847842 9.921328e-01 9.977731e-01 2 173910165 173910257 93 - 1.840 1.843 0.008
ENSG00000172845 E021 190.1920804 0.0002462188 8.014767e-01 8.971668e-01 2 173913070 173913266 197 - 2.099 2.091 -0.026
ENSG00000172845 E022 5.6242118 0.0048713639 5.265458e-01 7.195500e-01 2 173913267 173916832 3566 - 0.680 0.561 -0.522
ENSG00000172845 E023 178.9674162 0.0003594988 1.126518e-01 3.035884e-01 2 173918593 173918785 193 - 2.079 2.017 -0.210
ENSG00000172845 E024 0.1614157 0.0337661646 7.457727e-01   2 173934370 173934411 42 - 0.049 0.000 -9.310
ENSG00000172845 E025 487.9960174 0.0009258739 1.556855e-07 5.514627e-06 2 173954873 173955816 944 - 2.520 2.381 -0.461
ENSG00000172845 E026 191.1459645 0.0003674194 5.383734e-06 1.229204e-04 2 173955817 173956073 257 - 2.119 1.927 -0.644
ENSG00000172845 E027 47.4679650 0.0150018196 1.456473e-01 3.558682e-01 2 173956074 173956080 7 - 1.521 1.364 -0.538
ENSG00000172845 E028 82.3560056 0.0222714254 1.049007e-01 2.904703e-01 2 173956081 173956228 148 - 1.756 1.590 -0.561
ENSG00000172845 E029 23.8099371 0.0118206169 5.466046e-01 7.338725e-01 2 173956229 173956232 4 - 1.228 1.153 -0.269
ENSG00000172845 E030 2.1724970 0.0098978039 9.868997e-02 2.795261e-01 2 173962972 173963379 408 - 0.339 0.654 1.569
ENSG00000172845 E031 36.8139124 0.0012068723 7.660795e-01 8.762750e-01 2 173963761 173963874 114 - 1.402 1.378 -0.085
ENSG00000172845 E032 16.4052436 0.0021270345 7.939300e-01 8.927113e-01 2 173963875 173963883 9 - 1.062 1.095 0.119
ENSG00000172845 E033 15.5614217 0.0026529915 1.627612e-02 8.280337e-02 2 173963884 173964188 305 - 1.005 1.269 0.949
ENSG00000172845 E034 1.1073002 0.0365616067 5.323734e-03   2 173964189 173964404 216 - 0.132 0.654 3.303
ENSG00000172845 E035 12.3939719 0.0026407808 7.725715e-01 8.802079e-01 2 173964405 173964553 149 - 0.951 0.991 0.150
ENSG00000172845 E036 0.0000000       2 173964851 173964885 35 -      
ENSG00000172845 E037 8.3891150 0.0044148989 9.038658e-01 9.538381e-01 2 173965165 173965187 23 - 0.817 0.798 -0.074
ENSG00000172845 E038 11.1808615 0.0027216191 9.034730e-01 9.536386e-01 2 173965188 173965462 275 - 0.921 0.905 -0.060