ENSG00000172809

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311111 ENSG00000172809 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL38 protein_coding protein_coding 1738.226 1577.811 1193.591 437.7249 75.31464 -0.4026126 219.0693 170.6500 178.84136 52.52128 6.340392 0.06763598 0.12837500 0.1049667 0.15050000 0.04553333 1.044783e-01 1.138018e-06    
ENST00000439590 ENSG00000172809 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL38 protein_coding protein_coding 1738.226 1577.811 1193.591 437.7249 75.31464 -0.4026126 138.1391 177.6165 67.13223 49.58587 2.423200 -1.40355438 0.07539583 0.1136667 0.05646667 -0.05720000 1.138018e-06 1.138018e-06    
ENST00000534490 ENSG00000172809 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL38 protein_coding protein_coding 1738.226 1577.811 1193.591 437.7249 75.31464 -0.4026126 1354.2747 1203.1515 926.31734 334.56879 65.202485 -0.37723626 0.77920833 0.7619667 0.77536667 0.01340000 8.124367e-01 1.138018e-06    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172809 E001 4.113136 1.492914e-01 8.228834e-01 9.096554e-01 17 74203546 74203581 36 + 0.713 0.667 -0.193
ENSG00000172809 E002 65.449907 6.985279e-04 1.940774e-02 9.387208e-02 17 74203582 74203661 80 + 1.739 1.845 0.360
ENSG00000172809 E003 109.487237 2.143126e-03 1.056656e-01 2.918085e-01 17 74203662 74203674 13 + 1.988 2.055 0.223
ENSG00000172809 E004 129.447190 5.639907e-04 4.710016e-03 3.306064e-02 17 74203675 74203677 3 + 2.042 2.137 0.317
ENSG00000172809 E005 297.895875 4.695398e-03 9.668444e-01 9.853155e-01 17 74203678 74203692 15 + 2.464 2.457 -0.026
ENSG00000172809 E006 355.667484 3.846988e-03 8.607919e-01 9.307636e-01 17 74203693 74203693 1 + 2.536 2.536 -0.001
ENSG00000172809 E007 1529.094836 1.816167e-03 1.428889e-05 2.855810e-04 17 74203694 74203703 10 + 3.108 3.200 0.307
ENSG00000172809 E008 3657.748760 4.787713e-05 3.344575e-67 3.155476e-63 17 74203704 74203710 7 + 3.476 3.590 0.378
ENSG00000172809 E009 4840.240448 2.243671e-04 4.949666e-09 2.492046e-07 17 74203711 74203745 35 + 3.706 3.648 -0.191
ENSG00000172809 E010 54.975998 1.088910e-02 9.585118e-01 9.811346e-01 17 74203746 74203770 25 + 1.751 1.726 -0.085
ENSG00000172809 E011 36.786505 3.340889e-02 3.927865e-01 6.226620e-01 17 74203771 74203790 20 + 1.527 1.583 0.192
ENSG00000172809 E012 164.382021 2.067981e-02 7.234406e-01 8.501824e-01 17 74203791 74203917 127 + 2.208 2.199 -0.030
ENSG00000172809 E013 8906.710787 3.930203e-05 1.173873e-08 5.405386e-07 17 74203918 74203958 41 + 3.925 3.944 0.064
ENSG00000172809 E014 24.282396 1.539499e-02 5.427112e-01 7.310180e-01 17 74203959 74204129 171 + 1.365 1.403 0.131
ENSG00000172809 E015 11957.738490 1.302868e-04 2.892521e-01 5.297737e-01 17 74204130 74204190 61 + 4.073 4.057 -0.050
ENSG00000172809 E016 97.464127 1.971277e-01 3.924256e-01 6.223223e-01 17 74204191 74206283 2093 + 2.094 1.892 -0.677
ENSG00000172809 E017 13131.440851 2.540048e-05 5.470049e-07 1.676485e-05 17 74209187 74209309 123 + 4.120 4.098 -0.075
ENSG00000172809 E018 39.039110 7.627683e-02 4.076628e-01 6.342436e-01 17 74209310 74209461 152 + 1.664 1.529 -0.460
ENSG00000172809 E019 5204.708467 5.738327e-04 3.717268e-02 1.473605e-01 17 74209804 74209812 9 + 3.722 3.689 -0.110
ENSG00000172809 E020 4993.827828 5.322140e-04 1.664896e-02 8.415561e-02 17 74209813 74210655 843 + 3.707 3.669 -0.123