ENSG00000172534

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310441 ENSG00000172534 HEK293_OSMI2_6hA HEK293_TMG_6hB HCFC1 protein_coding protein_coding 60.65299 91.96265 36.50107 16.68254 1.847926 -1.332871 19.247233 29.614712 20.477537 4.0361399 0.6319706 -0.5320545 0.38030000 0.3299333 0.56216667 0.23223333 4.796275e-05 8.513288e-12 FALSE TRUE
ENST00000369984 ENSG00000172534 HEK293_OSMI2_6hA HEK293_TMG_6hB HCFC1 protein_coding protein_coding 60.65299 91.96265 36.50107 16.68254 1.847926 -1.332871 2.548560 0.000000 4.177952 0.0000000 1.2665374 8.7101012 0.06176667 0.0000000 0.11683333 0.11683333 8.513288e-12 8.513288e-12 FALSE TRUE
ENST00000444191 ENSG00000172534 HEK293_OSMI2_6hA HEK293_TMG_6hB HCFC1 protein_coding protein_coding 60.65299 91.96265 36.50107 16.68254 1.847926 -1.332871 28.649367 43.023020 4.894023 9.8540942 0.9365358 -3.1334063 0.37562500 0.4573667 0.13210000 -0.32526667 6.114950e-07 8.513288e-12 FALSE TRUE
MSTRG.35088.25 ENSG00000172534 HEK293_OSMI2_6hA HEK293_TMG_6hB HCFC1 protein_coding   60.65299 91.96265 36.50107 16.68254 1.847926 -1.332871 5.295290 8.281179 5.159446 0.9482888 0.2395229 -0.6815676 0.10823333 0.0939000 0.14253333 0.04863333 3.723137e-01 8.513288e-12 FALSE TRUE
MSTRG.35088.5 ENSG00000172534 HEK293_OSMI2_6hA HEK293_TMG_6hB HCFC1 protein_coding   60.65299 91.96265 36.50107 16.68254 1.847926 -1.332871 4.249114 10.281755 1.517071 2.4838335 1.5170715 -2.7526495 0.06022083 0.1087667 0.03866667 -0.07010000 2.656148e-01 8.513288e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172534 E001 5.054971 0.0062202027 3.081088e-05 5.528152e-04 X 153947557 153947558 2 - 0.001 0.888 12.121
ENSG00000172534 E002 228.885281 1.0452350855 2.917928e-01 5.324687e-01 X 153947559 153947653 95 - 1.993 2.419 1.425
ENSG00000172534 E003 273.487262 1.1300292667 3.250387e-01 5.642431e-01 X 153947654 153947666 13 - 2.091 2.493 1.342
ENSG00000172534 E004 374.119697 1.2448656192 3.416901e-01 5.794741e-01 X 153947667 153947718 52 - 2.225 2.628 1.344
ENSG00000172534 E005 577.573488 1.4111140728 3.820185e-01 6.139036e-01 X 153947719 153947839 121 - 2.429 2.814 1.281
ENSG00000172534 E006 792.901207 1.5235545931 4.032274e-01 6.308828e-01 X 153947840 153948017 178 - 2.576 2.949 1.241
ENSG00000172534 E007 420.195533 1.2953158236 3.586742e-01 5.947249e-01 X 153948018 153948042 25 - 2.290 2.676 1.287
ENSG00000172534 E008 348.327890 1.2275101273 3.478526e-01 5.852941e-01 X 153948043 153948048 6 - 2.208 2.595 1.292
ENSG00000172534 E009 571.695909 1.4028783486 3.736862e-01 6.071033e-01 X 153948049 153948147 99 - 2.421 2.810 1.294
ENSG00000172534 E010 282.406893 1.1624129565 3.509845e-01 5.881101e-01 X 153948148 153948151 4 - 2.132 2.501 1.234
ENSG00000172534 E011 1426.868084 1.7119876386 4.211470e-01 6.445024e-01 X 153948152 153948681 530 - 2.827 3.205 1.255
ENSG00000172534 E012 751.274899 1.4853449636 3.724244e-01 6.060310e-01 X 153948682 153949078 397 - 2.533 2.929 1.319
ENSG00000172534 E013 189.239873 1.0019821957 3.106874e-01 5.511753e-01 X 153949079 153949079 1 - 1.954 2.329 1.255
ENSG00000172534 E014 263.970766 1.1399888800 3.473686e-01 5.848471e-01 X 153949080 153949123 44 - 2.109 2.471 1.209
ENSG00000172534 E015 219.069989 1.0868965397 3.613395e-01 5.968019e-01 X 153949124 153949137 14 - 2.048 2.386 1.131
ENSG00000172534 E016 267.769299 1.1673334442 3.780328e-01 6.105553e-01 X 153949138 153949271 134 - 2.139 2.472 1.112
ENSG00000172534 E017 216.413247 1.1166775775 4.089540e-01 6.351903e-01 X 153949272 153949386 115 - 2.082 2.373 0.973
ENSG00000172534 E018 316.795516 0.0103023641 8.242935e-02 2.495792e-01 X 153949553 153949616 64 - 2.337 2.516 0.600
ENSG00000172534 E019 817.520558 0.0002659390 5.197543e-07 1.601347e-05 X 153950243 153950543 301 - 2.750 2.929 0.596
ENSG00000172534 E020 706.395003 0.0087126294 9.825232e-01 9.930379e-01 X 153950813 153950998 186 - 2.741 2.844 0.342
ENSG00000172534 E021 582.635773 0.0090110614 2.950780e-01 5.355974e-01 X 153951350 153951484 135 - 2.697 2.746 0.160
ENSG00000172534 E022 236.879262 0.0027237444 3.121683e-02 1.309677e-01 X 153951485 153951487 3 - 2.328 2.349 0.069
ENSG00000172534 E023 15.100867 0.0021252823 4.867108e-01 6.917231e-01 X 153951580 153951588 9 - 1.159 1.185 0.095
ENSG00000172534 E024 466.420003 0.0033071653 2.421496e-01 4.789547e-01 X 153951589 153951707 119 - 2.593 2.655 0.208
ENSG00000172534 E025 690.242161 0.0101860568 4.059431e-01 6.330144e-01 X 153951841 153952158 318 - 2.700 2.845 0.481
ENSG00000172534 E026 19.688934 0.0116092641 3.223747e-03 2.474258e-02 X 153952159 153952161 3 - 0.962 1.378 1.488
ENSG00000172534 E027 905.867366 0.0112350102 6.716183e-01 8.173144e-01 X 153952514 153952958 445 - 2.833 2.957 0.411
ENSG00000172534 E028 102.935984 0.0044027921 2.248426e-01 4.592282e-01 X 153952959 153953087 129 - 1.955 1.998 0.144
ENSG00000172534 E029 37.553665 0.0011131177 5.990313e-01 7.695687e-01 X 153953088 153953090 3 - 1.513 1.576 0.214
ENSG00000172534 E030 511.364986 0.0103975452 5.332737e-01 7.243986e-01 X 153953607 153953770 164 - 2.627 2.694 0.223
ENSG00000172534 E031 811.641819 0.0096122400 9.797245e-02 2.782177e-01 X 153954066 153954500 435 - 2.863 2.880 0.058
ENSG00000172534 E032 996.967758 0.0068933679 1.705497e-01 3.911787e-01 X 153954501 153955142 642 - 2.934 2.977 0.144
ENSG00000172534 E033 888.746581 0.0114749925 6.363055e-03 4.151497e-02 X 153955143 153955542 400 - 2.946 2.900 -0.155
ENSG00000172534 E034 582.804458 0.0102992899 2.069140e-02 9.830281e-02 X 153956191 153956411 221 - 2.747 2.725 -0.074
ENSG00000172534 E035 439.836600 0.0078798465 2.152113e-02 1.010374e-01 X 153956625 153956763 139 - 2.617 2.607 -0.033
ENSG00000172534 E036 449.389732 0.0046399017 2.663959e-02 1.171833e-01 X 153956918 153957060 143 - 2.611 2.623 0.040
ENSG00000172534 E037 573.531882 0.0028956414 9.141514e-05 1.386230e-03 X 153957314 153957533 220 - 2.741 2.718 -0.078
ENSG00000172534 E038 413.038390 0.0029803180 3.499620e-07 1.130523e-05 X 153957782 153957886 105 - 2.629 2.561 -0.227
ENSG00000172534 E039 561.490119 0.0055970153 2.370705e-04 3.078487e-03 X 153958025 153958249 225 - 2.751 2.699 -0.171
ENSG00000172534 E040 348.884880 0.0072228014 1.184300e-04 1.720162e-03 X 153958569 153958766 198 - 2.565 2.484 -0.271
ENSG00000172534 E041 327.161729 0.0148355628 2.000157e-03 1.706812e-02 X 153959331 153959470 140 - 2.547 2.449 -0.326
ENSG00000172534 E042 167.375785 0.0152723643 5.386214e-03 3.663355e-02 X 153959471 153959491 21 - 2.252 2.163 -0.298
ENSG00000172534 E043 384.591844 0.0126062414 1.031264e-02 5.945963e-02 X 153959802 153960008 207 - 2.587 2.535 -0.175
ENSG00000172534 E044 325.862515 0.0057640320 8.304667e-04 8.527834e-03 X 153960009 153960161 153 - 2.510 2.466 -0.148
ENSG00000172534 E045 391.464015 0.0016217257 3.000001e-13 3.403267e-11 X 153960235 153960414 180 - 2.627 2.527 -0.336
ENSG00000172534 E046 315.064048 0.0011445888 5.926103e-18 1.354493e-15 X 153961542 153961648 107 - 2.553 2.422 -0.434
ENSG00000172534 E047 316.914767 0.0003225469 9.666959e-26 5.295716e-23 X 153962222 153962306 85 - 2.560 2.425 -0.450
ENSG00000172534 E048 416.840493 0.0043167104 7.597915e-09 3.667711e-07 X 153963225 153963433 209 - 2.663 2.548 -0.384
ENSG00000172534 E049 391.273814 0.0079648757 2.729902e-06 6.844828e-05 X 153964124 153964284 161 - 2.642 2.517 -0.416
ENSG00000172534 E050 372.324592 0.0114638667 3.199054e-05 5.704851e-04 X 153964578 153964726 149 - 2.626 2.492 -0.447
ENSG00000172534 E051 1.271852 0.2141704447 9.655971e-01   X 153970009 153970129 121 - 0.292 0.361 0.436
ENSG00000172534 E052 1085.604866 0.0107522402 3.686486e-06 8.852520e-05 X 153970648 153972522 1875 - 3.090 2.955 -0.448