ENSG00000172375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336702 ENSG00000172375 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD2L protein_coding protein_coding 10.94998 14.6117 7.760472 0.6853086 0.6353045 -0.9120367 1.947939 2.7177399 0.6738498 0.9215215 0.13220228 -1.9959548 0.17205833 0.18160000 0.09046667 -0.09113333 0.558321026 0.005824398 FALSE TRUE
ENST00000525598 ENSG00000172375 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD2L protein_coding retained_intron 10.94998 14.6117 7.760472 0.6853086 0.6353045 -0.9120367 0.622189 0.5974239 0.6516376 0.2406438 0.03550683 0.1233376 0.06066667 0.04223333 0.08470000 0.04246667 0.469372829 0.005824398 TRUE TRUE
ENST00000529874 ENSG00000172375 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD2L protein_coding retained_intron 10.94998 14.6117 7.760472 0.6853086 0.6353045 -0.9120367 0.849368 0.2029715 1.5910395 0.1158520 0.47641074 2.9102763 0.08896250 0.01423333 0.19900000 0.18476667 0.005824398 0.005824398 FALSE TRUE
ENST00000648610 ENSG00000172375 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD2L protein_coding protein_coding 10.94998 14.6117 7.760472 0.6853086 0.6353045 -0.9120367 6.345287 9.5548844 4.3442796 0.7721791 0.38264830 -1.1353135 0.57115417 0.65423333 0.55923333 -0.09500000 0.623549730 0.005824398 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172375 E001 4.297080 0.1661955243 0.8688430190 0.935319950 11 119102198 119102375 178 + 0.702 0.677 -0.103
ENSG00000172375 E002 1.630393 0.0536311547 0.5992191333 0.769671031 11 119106715 119106741 27 + 0.307 0.419 0.663
ENSG00000172375 E003 1.458018 0.0153626094 0.7138958137 0.844299198 11 119106742 119106749 8 + 0.307 0.384 0.465
ENSG00000172375 E004 1.356412 0.0164271069 0.7099958364   11 119106750 119106774 25 + 0.405 0.345 -0.346
ENSG00000172375 E005 2.599810 0.1102272532 0.4624370589 0.674819272 11 119106775 119106878 104 + 0.609 0.484 -0.586
ENSG00000172375 E006 2.701604 0.4162835080 0.4004354962 0.628660125 11 119106879 119106941 63 + 0.610 0.495 -0.531
ENSG00000172375 E007 2.737693 0.0671953874 0.8639374011 0.932576765 11 119106942 119107070 129 + 0.553 0.535 -0.084
ENSG00000172375 E008 2.177688 0.0215934537 0.0769049547 0.238604190 11 119107071 119107126 56 + 0.180 0.536 2.247
ENSG00000172375 E009 1.214688 0.0153787590 0.0672735335   11 119107127 119107343 217 + 0.000 0.384 10.321
ENSG00000172375 E010 3.047525 0.0083878408 0.8959621932 0.949787374 11 119107344 119107374 31 + 0.552 0.584 0.143
ENSG00000172375 E011 4.655813 0.0061751612 0.9911631930 0.997317772 11 119107375 119107382 8 + 0.708 0.720 0.050
ENSG00000172375 E012 44.107859 0.3408456699 0.2158698873 0.448491214 11 119107383 119107512 130 + 1.423 1.663 0.821
ENSG00000172375 E013 67.597052 0.4083884541 0.1266835756 0.326535401 11 119107513 119107751 239 + 1.511 1.862 1.192
ENSG00000172375 E014 75.145787 0.5248273214 0.2405014848 0.477145303 11 119107752 119108095 344 + 1.634 1.893 0.876
ENSG00000172375 E015 1.803575 0.1283288817 0.6013311226 0.771030120 11 119110103 119110103 1 + 0.483 0.387 -0.507
ENSG00000172375 E016 76.875902 0.0216710401 0.3842112776 0.615766475 11 119110104 119110199 96 + 1.795 1.865 0.235
ENSG00000172375 E017 52.682420 0.0043402514 0.8213336238 0.908766709 11 119110561 119110586 26 + 1.669 1.694 0.087
ENSG00000172375 E018 96.407608 0.0011415919 0.0902573738 0.264242624 11 119110587 119110680 94 + 1.987 1.932 -0.186
ENSG00000172375 E019 4.346254 0.1476122117 0.2808550896 0.521104513 11 119110681 119110846 166 + 0.823 0.639 -0.752
ENSG00000172375 E020 106.490834 0.0053669354 0.0162474710 0.082701197 11 119110847 119110957 111 + 2.058 1.956 -0.343
ENSG00000172375 E021 54.647916 0.0017034507 0.0454039891 0.168586520 11 119111052 119111056 5 + 1.768 1.676 -0.310
ENSG00000172375 E022 122.260216 0.0010477172 0.0003701794 0.004439304 11 119111057 119111168 112 + 2.126 2.012 -0.382
ENSG00000172375 E023 131.912671 0.0004449768 0.0082601554 0.050520938 11 119111263 119111374 112 + 2.129 2.054 -0.250
ENSG00000172375 E024 91.146785 0.0008083690 0.2099292309 0.441757320 11 119111521 119111560 40 + 1.944 1.905 -0.130
ENSG00000172375 E025 102.058185 0.0004586676 0.7382954005 0.859440214 11 119111561 119111629 69 + 1.966 1.967 0.003
ENSG00000172375 E026 20.246722 0.1383016062 0.0251460455 0.112662961 11 119111630 119112327 698 + 1.505 1.150 -1.239
ENSG00000172375 E027 81.732464 0.0005676427 0.3618336107 0.597188097 11 119112328 119112392 65 + 1.835 1.889 0.183
ENSG00000172375 E028 1.093321 0.1611704219 0.9088939556   11 119112393 119112481 89 + 0.310 0.299 -0.067
ENSG00000172375 E029 109.028863 0.0005885353 0.2247294294 0.459041195 11 119112482 119112609 128 + 1.956 2.017 0.205
ENSG00000172375 E030 147.228118 0.0005471590 0.4559558066 0.670230961 11 119112700 119112874 175 + 2.100 2.138 0.129
ENSG00000172375 E031 10.946957 0.0647509926 0.0067637144 0.043535259 11 119112875 119113610 736 + 1.269 0.889 -1.381
ENSG00000172375 E032 71.342450 0.0020068094 0.7500915811 0.866829928 11 119113611 119113636 26 + 1.794 1.825 0.105
ENSG00000172375 E033 111.580292 0.0016820453 0.6086983247 0.776035071 11 119113637 119113712 76 + 1.982 2.018 0.120
ENSG00000172375 E034 10.098589 0.1273281165 0.2152207214 0.447801413 11 119113713 119113851 139 + 1.127 0.937 -0.696
ENSG00000172375 E035 15.062550 0.0362564309 0.4437561133 0.661183853 11 119113852 119113854 3 + 1.072 1.201 0.463
ENSG00000172375 E036 143.209751 0.0002987303 0.6085679113 0.775938708 11 119113855 119113988 134 + 2.093 2.124 0.103
ENSG00000172375 E037 1.326485 0.1091609328 0.7532921618   11 119113989 119114079 91 + 0.402 0.342 -0.352
ENSG00000172375 E038 223.981277 0.0018692779 0.7211434255 0.848877721 11 119114080 119114365 286 + 2.288 2.313 0.085
ENSG00000172375 E039 36.026077 0.0841219824 0.0475962487 0.174024969 11 119114366 119116024 1659 + 1.682 1.439 -0.830
ENSG00000172375 E040 2.901027 0.3256224692 0.3740723579 0.607414007 11 119116025 119116044 20 + 0.659 0.512 -0.660
ENSG00000172375 E041 514.379652 0.0014177618 0.0561701402 0.194021486 11 119116045 119118544 2500 + 2.624 2.679 0.183