ENSG00000172354

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303210 ENSG00000172354 HEK293_OSMI2_6hA HEK293_TMG_6hB GNB2 protein_coding protein_coding 267.0583 442.1215 129.2381 101.4632 3.865608 -1.774333 19.18874 29.43806 1.689406 8.083799 0.2085295 -4.115070 0.07215417 0.06573333 0.01316667 -0.05256667 2.829959e-09 2.829959e-09 FALSE TRUE
ENST00000427895 ENSG00000172354 HEK293_OSMI2_6hA HEK293_TMG_6hB GNB2 protein_coding protein_coding 267.0583 442.1215 129.2381 101.4632 3.865608 -1.774333 62.63031 100.35595 24.919183 18.870478 1.4976980 -2.009362 0.22631667 0.23383333 0.19363333 -0.04020000 6.885727e-01 2.829959e-09 FALSE TRUE
ENST00000451587 ENSG00000172354 HEK293_OSMI2_6hA HEK293_TMG_6hB GNB2 protein_coding protein_coding 267.0583 442.1215 129.2381 101.4632 3.865608 -1.774333 75.98995 125.56215 45.671248 20.865846 4.2254820 -1.458843 0.31655833 0.29600000 0.35206667 0.05606667 7.098838e-01 2.829959e-09 FALSE FALSE
MSTRG.30348.11 ENSG00000172354 HEK293_OSMI2_6hA HEK293_TMG_6hB GNB2 protein_coding   267.0583 442.1215 129.2381 101.4632 3.865608 -1.774333 100.57045 174.77388 51.364545 53.095004 2.4254357 -1.766447 0.34674167 0.37530000 0.39810000 0.02280000 9.493075e-01 2.829959e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172354 E001 34.920464 2.977459e-02 4.490161e-01 6.650104e-01 7 100673567 100673610 44 + 1.529 1.427 -0.350
ENSG00000172354 E002 9.593103 3.760502e-03 2.925278e-01 5.331968e-01 7 100673740 100673744 5 + 0.803 0.951 0.569
ENSG00000172354 E003 11.217151 6.743085e-03 2.123150e-01 4.444669e-01 7 100673745 100673748 4 + 0.846 1.014 0.632
ENSG00000172354 E004 32.310843 1.328757e-03 6.989428e-07 2.082031e-05 7 100673749 100673822 74 + 0.986 1.484 1.763
ENSG00000172354 E005 45.055468 3.267890e-03 4.406152e-10 2.733891e-08 7 100673823 100673877 55 + 1.042 1.633 2.064
ENSG00000172354 E006 69.579485 4.695689e-03 3.895241e-08 1.594746e-06 7 100673878 100673923 46 + 1.387 1.803 1.420
ENSG00000172354 E007 6.888083 8.793469e-02 6.167774e-05 9.965083e-04 7 100674793 100674852 60 + 1.266 0.547 -2.787
ENSG00000172354 E008 4.985120 3.462836e-01 2.139065e-01 4.462416e-01 7 100675286 100675441 156 + 0.917 0.616 -1.216
ENSG00000172354 E009 5.743565 1.411599e-01 4.995134e-02 1.795686e-01 7 100675727 100675850 124 + 1.060 0.633 -1.671
ENSG00000172354 E010 2.445740 1.154171e-01 2.720608e-02 1.188970e-01 7 100676118 100676120 3 + 0.800 0.348 -2.113
ENSG00000172354 E011 2.445740 1.154171e-01 2.720608e-02 1.188970e-01 7 100676121 100676137 17 + 0.800 0.348 -2.113
ENSG00000172354 E012 60.886207 2.776532e-02 3.190614e-01 5.587646e-01 7 100676138 100676176 39 + 1.782 1.662 -0.405
ENSG00000172354 E013 165.873987 3.889110e-03 2.290970e-04 2.991154e-03 7 100676177 100676222 46 + 1.966 2.148 0.610
ENSG00000172354 E014 121.443149 3.304647e-03 9.439962e-03 5.570073e-02 7 100676223 100676232 10 + 1.872 2.010 0.462
ENSG00000172354 E015 757.407335 9.020201e-05 5.595995e-01 7.430057e-01 7 100676233 100676322 90 + 2.765 2.779 0.045
ENSG00000172354 E016 712.808838 9.221013e-05 4.398727e-02 1.650439e-01 7 100676535 100676547 13 + 2.774 2.744 -0.099
ENSG00000172354 E017 842.061240 1.007276e-04 2.267902e-03 1.884625e-02 7 100676548 100676573 26 + 2.857 2.814 -0.145
ENSG00000172354 E018 1520.022141 1.230011e-04 1.934352e-02 9.365039e-02 7 100676693 100676799 107 + 3.098 3.072 -0.084
ENSG00000172354 E019 16.401992 6.715845e-02 2.711743e-02 1.186409e-01 7 100676800 100676835 36 + 1.400 1.050 -1.239
ENSG00000172354 E020 49.525373 8.029263e-02 9.710410e-03 5.686579e-02 7 100676836 100677351 516 + 1.892 1.487 -1.375
ENSG00000172354 E021 868.065130 4.867315e-04 2.202624e-01 4.538470e-01 7 100677352 100677369 18 + 2.849 2.828 -0.068
ENSG00000172354 E022 1126.910317 8.763808e-05 3.020445e-01 5.426109e-01 7 100677370 100677415 46 + 2.957 2.946 -0.036
ENSG00000172354 E023 2357.384021 6.554957e-05 9.585071e-01 9.811346e-01 7 100677498 100677660 163 + 3.266 3.269 0.010
ENSG00000172354 E024 11.378299 5.432827e-03 3.762039e-02 1.486274e-01 7 100677661 100677751 91 + 1.177 0.943 -0.851
ENSG00000172354 E025 1918.630135 1.856884e-04 1.848125e-01 4.102561e-01 7 100677752 100677818 67 + 3.190 3.175 -0.051
ENSG00000172354 E026 3418.542123 4.627300e-05 6.904227e-01 8.293345e-01 7 100678098 100678299 202 + 3.430 3.429 -0.002
ENSG00000172354 E027 3590.129150 7.148848e-05 8.101053e-02 2.468324e-01 7 100678398 100678614 217 + 3.437 3.453 0.052
ENSG00000172354 E028 2514.167423 1.170375e-03 3.515346e-02 1.419808e-01 7 100678695 100679174 480 + 3.260 3.299 0.128