ENSG00000172270

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353555 ENSG00000172270 HEK293_OSMI2_6hA HEK293_TMG_6hB BSG protein_coding protein_coding 1013.675 1429.445 707.9203 157.6556 19.53011 -1.013786 745.88677 1031.7398 484.8158 114.916647 15.361856 -1.0895547 0.7247417 0.7217000 0.6847333 -0.03696667 0.299625447 0.003419327 FALSE TRUE
ENST00000573216 ENSG00000172270 HEK293_OSMI2_6hA HEK293_TMG_6hB BSG protein_coding protein_coding 1013.675 1429.445 707.9203 157.6556 19.53011 -1.013786 91.99464 136.8311 111.4760 6.451484 4.612610 -0.2956385 0.1075875 0.0972000 0.1573333 0.06013333 0.003419327 0.003419327 FALSE FALSE
ENST00000680065 ENSG00000172270 HEK293_OSMI2_6hA HEK293_TMG_6hB BSG protein_coding protein_coding 1013.675 1429.445 707.9203 157.6556 19.53011 -1.013786 143.86104 212.2702 89.3440 32.501699 3.913166 -1.2483653 0.1367000 0.1469667 0.1263333 -0.02063333 0.704127698 0.003419327 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172270 E001 7.390709e-01 0.2866923128 2.938150e-01   19 571277 571309 33 + 0.001 0.266 9.053
ENSG00000172270 E002 7.659621e+00 0.0698374875 1.048299e-02 0.0601863763 19 571310 571579 270 + 0.482 0.981 2.073
ENSG00000172270 E003 2.613896e+00 0.0093192031 1.358698e-01 0.3411370698 19 572474 572528 55 + 0.305 0.586 1.486
ENSG00000172270 E004 3.257178e+01 0.0015205530 5.738729e-02 0.1969095181 19 572529 572570 42 + 1.379 1.521 0.489
ENSG00000172270 E005 3.500769e+01 0.0022736170 2.348742e-02 0.1075064645 19 572571 572571 1 + 1.388 1.557 0.579
ENSG00000172270 E006 6.206348e+02 0.0068383899 3.223827e-01 0.5618520941 19 572572 572593 22 + 2.710 2.762 0.171
ENSG00000172270 E007 6.449911e+02 0.0066618737 3.891547e-01 0.6198317901 19 572594 572595 2 + 2.731 2.777 0.151
ENSG00000172270 E008 1.760265e+03 0.0015135337 6.625748e-06 0.0001470663 19 572596 572609 14 + 3.264 3.173 -0.301
ENSG00000172270 E009 2.809871e+03 0.0012601622 4.050952e-01 0.6323603588 19 572610 572618 9 + 3.413 3.400 -0.044
ENSG00000172270 E010 2.966966e+03 0.0009207197 4.809859e-01 0.6877539256 19 572619 572622 4 + 3.434 3.425 -0.030
ENSG00000172270 E011 3.324614e+03 0.0007993129 3.583736e-01 0.5945015867 19 572623 572634 12 + 3.485 3.473 -0.039
ENSG00000172270 E012 5.317677e+03 0.0004258505 5.820262e-01 0.7583903525 19 572635 572701 67 + 3.683 3.679 -0.014
ENSG00000172270 E013 4.406166e+00 0.0197561302 6.738645e-01 0.8188216667 19 575047 575048 2 + 0.747 0.687 -0.248
ENSG00000172270 E014 9.764153e+00 0.0225263402 7.656925e-01 0.8760841885 19 575049 575140 92 + 0.961 1.001 0.149
ENSG00000172270 E015 1.224731e+01 0.0606879529 9.865878e-01 0.9951505895 19 575213 575386 174 + 1.068 1.083 0.054
ENSG00000172270 E016 2.455939e+01 0.0251617644 4.540255e-01 0.6687622136 19 577774 578121 348 + 1.298 1.384 0.300
ENSG00000172270 E017 1.016876e+01 0.0795926803 8.196372e-01 0.9078846691 19 578122 578212 91 + 0.961 1.021 0.223
ENSG00000172270 E018 4.107807e+01 0.0294163048 9.734957e-01 0.9886652253 19 578850 579499 650 + 1.577 1.578 0.004
ENSG00000172270 E019 3.470772e+03 0.0010718746 9.357463e-01 0.9700642544 19 579500 579508 9 + 3.495 3.495 -0.001
ENSG00000172270 E020 3.980092e+03 0.0013386393 3.623970e-01 0.5976532512 19 579509 579523 15 + 3.566 3.550 -0.053
ENSG00000172270 E021 6.494512e+03 0.0009803025 2.194022e-02 0.1023838550 19 579524 579579 56 + 3.791 3.757 -0.116
ENSG00000172270 E022 7.997932e+03 0.0004085927 1.277774e-03 0.0119920102 19 579580 579656 77 + 3.880 3.848 -0.108
ENSG00000172270 E023 2.404458e+02 0.0046943065 8.997280e-02 0.2637389275 19 579657 580378 722 + 2.284 2.357 0.243
ENSG00000172270 E024 8.311413e+03 0.0001471241 8.433176e-03 0.0513038627 19 580379 580461 83 + 3.886 3.870 -0.055
ENSG00000172270 E025 7.711495e+01 0.0085785785 4.695650e-01 0.6797047511 19 580462 580645 184 + 1.879 1.833 -0.154
ENSG00000172270 E026 4.653166e+03 0.0006413495 3.067246e-03 0.0238191529 19 580646 580646 1 + 3.649 3.611 -0.127
ENSG00000172270 E027 5.028096e+03 0.0006710482 1.493185e-04 0.0020904960 19 580647 580655 9 + 3.691 3.641 -0.166
ENSG00000172270 E028 1.015115e+04 0.0001169842 1.808937e-03 0.0157594554 19 580656 580782 127 + 3.974 3.956 -0.057
ENSG00000172270 E029 1.170278e+04 0.0004136143 6.402080e-03 0.0416910978 19 581315 581591 277 + 4.002 4.030 0.094
ENSG00000172270 E030 4.075278e+03 0.0003574743 1.396280e-06 0.0000379879 19 582306 582330 25 + 3.524 3.580 0.185
ENSG00000172270 E031 1.245104e+02 0.0003405926 4.473004e-03 0.0317832170 19 582331 582513 183 + 2.119 2.026 -0.312
ENSG00000172270 E032 3.283980e+03 0.0004231155 2.360138e-04 0.0030684867 19 582514 582517 4 + 3.437 3.484 0.157
ENSG00000172270 E033 3.218266e+03 0.0004855644 2.115693e-03 0.0178451051 19 582518 582519 2 + 3.432 3.474 0.139
ENSG00000172270 E034 3.250768e+03 0.0004866406 8.702291e-04 0.0088504564 19 582520 582522 3 + 3.434 3.479 0.150
ENSG00000172270 E035 4.724438e+03 0.0007323173 5.289533e-02 0.1864743847 19 582523 582578 56 + 3.607 3.637 0.100
ENSG00000172270 E036 2.186925e+03 0.0012559193 4.603429e-01 0.6733691029 19 582579 582582 4 + 3.282 3.299 0.058
ENSG00000172270 E037 8.813949e+00 0.0037425587 3.136273e-01 0.5538457681 19 582583 582613 31 + 0.852 0.981 0.489
ENSG00000172270 E038 1.530690e+04 0.0008607177 6.170459e-03 0.0405623739 19 582750 583494 745 + 4.111 4.149 0.127