ENSG00000172262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306938 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding protein_coding 15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 2.0755141 0.7131615 3.6230946 0.35994822 0.52492694 2.32880911 0.15862500 0.10440000 0.14526667 0.040866667 8.521297e-01 1.084267e-09 FALSE TRUE
ENST00000503599 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding retained_intron 15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 0.4681909 0.4508231 0.4723405 0.08896113 0.12363953 0.06583897 0.04635833 0.07080000 0.01903333 -0.051766667 2.891867e-02 1.084267e-09   FALSE
ENST00000504359 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding processed_transcript 15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 0.4190115 0.0000000 1.4714449 0.00000000 0.76778231 7.21086114 0.01678333 0.00000000 0.05723333 0.057233333 4.845553e-01 1.084267e-09   FALSE
ENST00000505606 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding protein_coding 15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 1.8277110 0.8122625 2.7918189 0.48895538 0.29038934 1.76869283 0.13200417 0.15206667 0.11143333 -0.040633333 9.690915e-01 1.084267e-09 FALSE TRUE
ENST00000509156 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding protein_coding 15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 1.6275337 0.3390578 4.0023684 0.17117650 0.54235614 3.52291630 0.07586250 0.05653333 0.15936667 0.102833333 5.280433e-01 1.084267e-09 FALSE TRUE
ENST00000509634 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding protein_coding 15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 2.4625030 1.0639536 3.5573732 0.38274439 0.31630067 1.73193042 0.15383750 0.16026667 0.14280000 -0.017466667 9.683609e-01 1.084267e-09 FALSE TRUE
ENST00000510026 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding nonsense_mediated_decay 15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 1.4266531 0.7245069 2.7937303 0.09078251 0.03274859 1.93249962 0.08757500 0.12203333 0.11210000 -0.009933333 1.000000e+00 1.084267e-09 FALSE TRUE
MSTRG.26133.18 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding   15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 1.9210576 0.0000000 3.6147509 0.00000000 0.58030302 8.50173804 0.08296667 0.00000000 0.14613333 0.146133333 1.084267e-09 1.084267e-09 FALSE TRUE
MSTRG.26133.2 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding   15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 0.3989849 0.3778596 0.3479304 0.11285774 0.07031340 -0.11585525 0.03536250 0.06616667 0.01376667 -0.052400000 1.017401e-01 1.084267e-09   FALSE
MSTRG.26133.4 ENSG00000172262 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF131 protein_coding   15.17272 6.26223 24.97445 0.7478674 0.7007992 1.99398 0.6309944 0.8212887 0.4178998 0.32739048 0.17838411 -0.95807673 0.06529167 0.12526667 0.01716667 -0.108100000 2.523724e-02 1.084267e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172262 E001 0.8217936 0.0187805289 3.582621e-01   5 43065176 43065233 58 + 0.176 0.351 1.314
ENSG00000172262 E002 4.5719975 0.2052170706 2.437159e-03 1.992709e-02 5 43067475 43067580 106 + 0.395 1.105 2.986
ENSG00000172262 E003 2.5133385 0.3131077933 1.677268e-02 8.463369e-02 5 43067581 43067589 9 + 0.259 0.875 2.998
ENSG00000172262 E004 4.5910860 0.0499262948 1.927822e-06 5.053071e-05 5 43067590 43067634 45 + 0.368 1.131 3.230
ENSG00000172262 E005 1.5360463 0.3137354234 1.722967e-03 1.518262e-02 5 43067635 43067786 152 + 0.067 0.809 5.037
ENSG00000172262 E006 7.0524524 0.0944470044 1.309775e-04 1.872936e-03 5 43067970 43068050 81 + 0.565 1.246 2.636
ENSG00000172262 E007 4.5271100 0.0662539093 1.495298e-03 1.358600e-02 5 43068051 43068056 6 + 0.478 1.021 2.245
ENSG00000172262 E008 7.3767701 0.0385024952 2.891587e-05 5.226245e-04 5 43068057 43068115 59 + 0.621 1.226 2.319
ENSG00000172262 E009 10.7599517 0.0101531589 1.816010e-09 1.008173e-07 5 43068116 43068217 102 + 0.741 1.404 2.431
ENSG00000172262 E010 6.0532285 0.0493279813 1.916358e-07 6.634895e-06 5 43071167 43071438 272 + 0.428 1.252 3.331
ENSG00000172262 E011 2.6185912 0.0626087649 2.697243e-03 2.155446e-02 5 43079900 43079954 55 + 0.302 0.861 2.642
ENSG00000172262 E012 5.0237344 0.0058086340 3.503969e-06 8.494712e-05 5 43079955 43080205 251 + 0.478 1.108 2.559
ENSG00000172262 E013 4.4726538 0.0627913728 7.366197e-02 2.320871e-01 5 43080206 43080503 298 + 0.586 0.918 1.351
ENSG00000172262 E014 0.1308682 0.0308008978 1.201211e-01   5 43093023 43093558 536 + 0.000 0.210 11.922
ENSG00000172262 E015 0.6653672 0.0382531324 2.236406e-01   5 43099020 43099338 319 + 0.125 0.352 1.897
ENSG00000172262 E016 0.1426347 0.0315288343 1.000000e+00   5 43116447 43116630 184 + 0.067 0.000 -10.329
ENSG00000172262 E017 0.3206185 0.0274424043 1.000000e+00   5 43119923 43120051 129 + 0.125 0.000 -11.345
ENSG00000172262 E018 0.4868358 0.2175687761 6.440826e-01   5 43120883 43120913 31 + 0.127 0.208 0.853
ENSG00000172262 E019 0.4868358 0.2175687761 6.440826e-01   5 43120914 43120917 4 + 0.127 0.208 0.853
ENSG00000172262 E020 0.6294705 0.0229431274 8.817720e-01   5 43120918 43120919 2 + 0.177 0.210 0.305
ENSG00000172262 E021 11.9940409 0.0171699739 2.730707e-01 5.129265e-01 5 43120920 43121123 204 + 1.063 0.927 -0.504
ENSG00000172262 E022 1.4758422 0.0125795242 4.147395e-01 6.396250e-01 5 43121508 43121528 21 + 0.369 0.210 -1.107
ENSG00000172262 E023 0.6268817 0.1802756558 4.308774e-01   5 43121533 43121535 3 + 0.222 0.000 -11.694
ENSG00000172262 E024 0.7992560 0.1331420856 1.000000e+00   5 43121536 43121539 4 + 0.222 0.211 -0.098
ENSG00000172262 E025 4.7642199 0.0078277307 9.678636e-02 2.760961e-01 5 43121540 43121568 29 + 0.742 0.457 -1.276
ENSG00000172262 E026 0.0000000       5 43121596 43121597 2 +      
ENSG00000172262 E027 9.6562879 0.0032369052 7.025795e-01 8.372043e-01 5 43121598 43121683 86 + 0.964 0.927 -0.137
ENSG00000172262 E028 25.8795316 0.0016808163 3.271803e-01 5.662965e-01 5 43121684 43121828 145 + 1.364 1.293 -0.245
ENSG00000172262 E029 24.5187259 0.0123308645 3.763383e-01 6.092788e-01 5 43121829 43122038 210 + 1.301 1.401 0.349
ENSG00000172262 E030 29.1815670 0.0016792515 6.065005e-01 7.745529e-01 5 43122039 43122043 5 + 1.382 1.433 0.177
ENSG00000172262 E031 48.5493221 0.0035880528 1.894655e-01 4.162981e-01 5 43122044 43122088 45 + 1.624 1.547 -0.262
ENSG00000172262 E032 68.5857629 0.0008295279 9.108786e-02 2.656485e-01 5 43122089 43122177 89 + 1.773 1.695 -0.263
ENSG00000172262 E033 56.7685410 0.0007598858 1.453066e-02 7.636765e-02 5 43123209 43123250 42 + 1.702 1.569 -0.452
ENSG00000172262 E034 65.0640204 0.0006554152 2.843961e-03 2.246776e-02 5 43123251 43123310 60 + 1.765 1.611 -0.524
ENSG00000172262 E035 3.9267114 0.0080500645 2.510981e-01 4.891455e-01 5 43123311 43125046 1736 + 0.655 0.457 -0.914
ENSG00000172262 E036 88.8839849 0.0006895355 6.080115e-02 2.046334e-01 5 43139165 43139309 145 + 1.884 1.809 -0.252
ENSG00000172262 E037 173.0532442 0.0002781477 1.810396e-04 2.460165e-03 5 43161249 43161606 358 + 2.179 2.069 -0.368
ENSG00000172262 E038 16.8423937 0.0067644420 1.004644e-01 2.826257e-01 5 43161607 43161613 7 + 1.209 1.039 -0.612
ENSG00000172262 E039 13.8669178 0.0028599429 1.829121e-01 4.077591e-01 5 43161614 43161708 95 + 1.126 0.987 -0.507
ENSG00000172262 E040 100.6624573 0.0025244460 3.504746e-01 5.876760e-01 5 43161709 43161830 122 + 1.934 1.902 -0.105
ENSG00000172262 E041 97.6132943 0.0032133577 2.453186e-02 1.107851e-01 5 43161831 43161931 101 + 1.934 1.832 -0.342
ENSG00000172262 E042 0.1779838 0.0344053783 1.000000e+00   5 43167930 43168029 100 + 0.067 0.000 -10.306
ENSG00000172262 E043 0.3447487 0.2602444704 4.432303e-02   5 43173132 43173317 186 + 0.000 0.354 12.200
ENSG00000172262 E044 92.9980587 0.0012491297 3.808008e-01 6.128575e-01 5 43173318 43173448 131 + 1.898 1.871 -0.092
ENSG00000172262 E045 71.5379237 0.0048396930 5.061126e-01 7.050305e-01 5 43174447 43174494 48 + 1.785 1.759 -0.087
ENSG00000172262 E046 324.5550087 0.0002294051 1.134843e-01 3.049672e-01 5 43174495 43175455 961 + 2.418 2.464 0.154
ENSG00000172262 E047 149.2467538 0.0024259765 1.367959e-01 3.425984e-01 5 43175456 43176324 869 + 2.078 2.146 0.228
ENSG00000172262 E048 1.1904555 0.0138033638 8.267850e-01   5 43179829 43179950 122 + 0.302 0.351 0.307
ENSG00000172262 E049 1.2443254 0.0152505292 1.496257e-02   5 43191753 43192021 269 + 0.177 0.614 2.630