ENSG00000172239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306846 ENSG00000172239 HEK293_OSMI2_6hA HEK293_TMG_6hB PAIP1 protein_coding protein_coding 41.9568 23.78631 58.80737 6.562941 1.985225 1.305504 5.586587 2.776436 6.745780 0.9812633 0.3795077 1.2777012 0.13695417 0.11003333 0.11533333 0.00530000 9.721531e-01 3.146346e-26 FALSE TRUE
ENST00000338972 ENSG00000172239 HEK293_OSMI2_6hA HEK293_TMG_6hB PAIP1 protein_coding protein_coding 41.9568 23.78631 58.80737 6.562941 1.985225 1.305504 2.219340 2.196528 2.753228 0.4931725 0.7117793 0.3245768 0.05473750 0.09616667 0.04616667 -0.05000000 2.475412e-01 3.146346e-26 FALSE TRUE
ENST00000436644 ENSG00000172239 HEK293_OSMI2_6hA HEK293_TMG_6hB PAIP1 protein_coding protein_coding 41.9568 23.78631 58.80737 6.562941 1.985225 1.305504 25.507039 16.686085 38.729730 4.8680842 1.5338653 1.2143041 0.64955000 0.69350000 0.65856667 -0.03493333 7.502505e-01 3.146346e-26 FALSE TRUE
ENST00000504639 ENSG00000172239 HEK293_OSMI2_6hA HEK293_TMG_6hB PAIP1 protein_coding nonsense_mediated_decay 41.9568 23.78631 58.80737 6.562941 1.985225 1.305504 1.139944 1.345108 0.000000 0.8921420 0.0000000 -7.0822640 0.02798750 0.05843333 0.00000000 -0.05843333 1.726435e-01 3.146346e-26 TRUE TRUE
ENST00000511321 ENSG00000172239 HEK293_OSMI2_6hA HEK293_TMG_6hB PAIP1 protein_coding protein_coding 41.9568 23.78631 58.80737 6.562941 1.985225 1.305504 6.038535 0.000000 8.046307 0.0000000 0.6898401 9.6539748 0.09279583 0.00000000 0.13660000 0.13660000 3.146346e-26 3.146346e-26 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172239 E001 62.9039577 0.0206718958 1.385477e-01 3.453162e-01 5 43526267 43527091 825 - 1.828 1.705 -0.418
ENSG00000172239 E002 7.7304668 0.1082048326 8.713478e-01 9.366824e-01 5 43527092 43527092 1 - 0.916 0.941 0.094
ENSG00000172239 E003 8.3787183 0.0946399150 9.611828e-01 9.825908e-01 5 43527093 43527112 20 - 0.954 0.961 0.024
ENSG00000172239 E004 10.3444016 0.1261617938 8.663716e-01 9.339678e-01 5 43527113 43527144 32 - 1.039 1.037 -0.006
ENSG00000172239 E005 9.2188314 0.0553540319 4.847481e-01 6.903516e-01 5 43527145 43527184 40 - 0.941 1.059 0.437
ENSG00000172239 E006 141.8381257 0.0003515429 1.850037e-01 4.105358e-01 5 43527185 43527469 285 - 2.126 2.168 0.139
ENSG00000172239 E007 86.7015777 0.0030196973 3.091719e-01 5.496703e-01 5 43529786 43529796 11 - 1.912 1.961 0.165
ENSG00000172239 E008 207.6060751 0.0003593900 9.318433e-01 9.680461e-01 5 43529797 43529879 83 - 2.308 2.305 -0.008
ENSG00000172239 E009 229.6922788 0.0002840277 2.287315e-01 4.637354e-01 5 43533738 43533792 55 - 2.362 2.333 -0.097
ENSG00000172239 E010 318.0063404 0.0001967481 7.711355e-01 8.793456e-01 5 43534853 43534970 118 - 2.494 2.488 -0.019
ENSG00000172239 E011 321.6636934 0.0001623576 4.898806e-01 6.939064e-01 5 43535534 43535640 107 - 2.491 2.506 0.048
ENSG00000172239 E012 200.6400466 0.0002450032 3.420085e-01 5.797482e-01 5 43536819 43536853 35 - 2.301 2.278 -0.079
ENSG00000172239 E013 188.4322142 0.0002364855 1.760043e-01 3.984686e-01 5 43536854 43536899 46 - 2.278 2.243 -0.119
ENSG00000172239 E014 231.1403362 0.0034681428 6.297959e-01 7.903525e-01 5 43536900 43536944 45 - 2.362 2.334 -0.092
ENSG00000172239 E015 194.3596672 0.0090782190 8.587256e-01 9.296962e-01 5 43538924 43538928 5 - 2.286 2.255 -0.101
ENSG00000172239 E016 345.0721548 0.0003164767 4.801845e-02 1.750260e-01 5 43538929 43539035 107 - 2.541 2.499 -0.139
ENSG00000172239 E017 251.2491701 0.0002283093 1.499932e-02 7.807839e-02 5 43543004 43543060 57 - 2.407 2.351 -0.190
ENSG00000172239 E018 212.3554874 0.0002210167 6.522465e-02 2.143853e-01 5 43543061 43543116 56 - 2.332 2.287 -0.153
ENSG00000172239 E019 309.3630992 0.0002462671 7.077301e-01 8.403933e-01 5 43547728 43547913 186 - 2.483 2.476 -0.023
ENSG00000172239 E020 186.2999856 0.0004464528 1.026390e-01 2.864920e-01 5 43555830 43555961 132 - 2.245 2.292 0.156
ENSG00000172239 E021 74.8869921 0.0005204221 2.467181e-02 1.112012e-01 5 43555962 43555999 38 - 1.834 1.929 0.317
ENSG00000172239 E022 0.7272023 0.0261758638 8.586868e-01   5 43556203 43556439 237 - 0.236 0.270 0.259
ENSG00000172239 E023 3.3623145 0.0249631118 9.975604e-01 1.000000e+00 5 43556440 43556581 142 - 0.616 0.607 -0.038
ENSG00000172239 E024 55.1466936 0.0013711031 1.580072e-08 7.089370e-07 5 43556582 43556818 237 - 1.622 1.900 0.941
ENSG00000172239 E025 57.5422376 0.0076944871 3.866953e-08 1.585077e-06 5 43556819 43557093 275 - 1.600 1.946 1.169
ENSG00000172239 E026 8.0533139 0.0081596583 8.546162e-03 5.182043e-02 5 43557340 43557350 11 - 0.814 1.118 1.134
ENSG00000172239 E027 9.5788943 0.0033343098 3.183613e-03 2.450930e-02 5 43557351 43557700 350 - 0.874 1.184 1.138
ENSG00000172239 E028 0.1779838 0.0401707840 1.000000e+00   5 43557701 43557758 58 - 0.094 0.000 -7.748