ENSG00000172175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345724 ENSG00000172175 HEK293_OSMI2_6hA HEK293_TMG_6hB MALT1 protein_coding protein_coding 2.415927 0.6871535 4.039157 0.127334 0.4901673 2.538073 0.30535476 0.0000000 0.6789365 0.0000000 0.16624152 6.106299 0.08270417 0.0000 0.17630000 0.17630000 2.976278e-02 1.963227e-05 FALSE TRUE
ENST00000587438 ENSG00000172175 HEK293_OSMI2_6hA HEK293_TMG_6hB MALT1 protein_coding retained_intron 2.415927 0.6871535 4.039157 0.127334 0.4901673 2.538073 0.09059715 0.0000000 0.1993929 0.0000000 0.11941266 4.388141 0.02673750 0.0000 0.05003333 0.05003333 7.309446e-01 1.963227e-05 FALSE FALSE
ENST00000591792 ENSG00000172175 HEK293_OSMI2_6hA HEK293_TMG_6hB MALT1 protein_coding protein_coding 2.415927 0.6871535 4.039157 0.127334 0.4901673 2.538073 0.48356284 0.0000000 0.7795940 0.0000000 0.40080523 6.303039 0.10708750 0.0000 0.17270000 0.17270000 5.488221e-01 1.963227e-05 FALSE FALSE
ENST00000649217 ENSG00000172175 HEK293_OSMI2_6hA HEK293_TMG_6hB MALT1 protein_coding protein_coding 2.415927 0.6871535 4.039157 0.127334 0.4901673 2.538073 1.39118512 0.6730962 2.1389165 0.1359244 0.07690606 1.653449 0.72991250 0.9714 0.54346667 -0.42793333 1.963227e-05 1.963227e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172175 E001 0.9819241 0.228794582 0.35702365   18 58671465 58671531 67 + 0.215 0.453 1.520
ENSG00000172175 E002 1.3570327 0.014629020 0.02938091   18 58671532 58671565 34 + 0.218 0.621 2.287
ENSG00000172175 E003 7.8462955 0.309436752 0.15336234 0.36713191 18 58671566 58671852 287 + 0.781 1.107 1.226
ENSG00000172175 E004 0.0000000       18 58672207 58672336 130 +      
ENSG00000172175 E005 5.3030118 0.110795365 0.49759560 0.69921466 18 58681170 58681170 1 + 0.700 0.829 0.518
ENSG00000172175 E006 16.0354231 0.065022975 0.57413850 0.75312578 18 58681171 58681323 153 + 1.131 1.213 0.290
ENSG00000172175 E007 10.5186687 0.068632285 0.43429918 0.65446939 18 58681324 58681336 13 + 1.007 0.870 -0.513
ENSG00000172175 E008 21.4222171 0.004891619 0.98531748 0.99443755 18 58696366 58696487 122 + 1.262 1.290 0.098
ENSG00000172175 E009 26.2339235 0.001551785 0.40952735 0.63571448 18 58700441 58700591 151 + 1.356 1.317 -0.137
ENSG00000172175 E010 2.7561370 0.008506946 0.45431120 0.66897737 18 58709322 58709377 56 + 0.471 0.622 0.701
ENSG00000172175 E011 33.4898048 0.001149244 0.11107249 0.30072961 18 58709378 58709556 179 + 1.468 1.379 -0.308
ENSG00000172175 E012 0.8428035 0.765894674 0.86322283   18 58709557 58709975 419 + 0.228 0.207 -0.180
ENSG00000172175 E013 24.1331660 0.004121871 0.01538291 0.07952070 18 58709976 58710072 97 + 1.353 1.157 -0.692
ENSG00000172175 E014 12.3685902 0.002787691 0.27931936 0.51943552 18 58710921 58710953 33 + 1.065 0.967 -0.359
ENSG00000172175 E015 12.5747364 0.003341902 0.01934276 0.09364939 18 58714083 58714109 27 + 1.095 0.828 -0.998
ENSG00000172175 E016 14.1155501 0.003173565 0.05247523 0.18541809 18 58715935 58715967 33 + 1.133 0.936 -0.720
ENSG00000172175 E017 0.0000000       18 58720380 58720422 43 +      
ENSG00000172175 E018 32.6620147 0.001356613 0.20092679 0.43086926 18 58723048 58723251 204 + 1.456 1.390 -0.227
ENSG00000172175 E019 20.4050998 0.010721301 0.50867258 0.70694011 18 58733397 58733451 55 + 1.226 1.317 0.320
ENSG00000172175 E020 20.0793863 0.002083376 0.31044322 0.55094473 18 58733452 58733509 58 + 1.213 1.330 0.411
ENSG00000172175 E021 21.6985621 0.001719396 0.61836600 0.78268443 18 58733510 58733574 65 + 1.259 1.330 0.250
ENSG00000172175 E022 0.1426347 0.032548672 1.00000000   18 58733575 58733641 67 + 0.066 0.000 -9.208
ENSG00000172175 E023 0.3040503 0.024441170 1.00000000   18 58733642 58733881 240 + 0.123 0.000 -10.192
ENSG00000172175 E024 0.5008152 0.030736353 0.56268467   18 58733882 58733980 99 + 0.173 0.000 -10.716
ENSG00000172175 E025 0.5173834 0.057218008 0.56423594   18 58733981 58734306 326 + 0.174 0.000 -10.627
ENSG00000172175 E026 23.3563846 0.002582107 0.75400748 0.86912837 18 58734307 58734381 75 + 1.289 1.343 0.190
ENSG00000172175 E027 0.3337900 0.036235220 0.34123347   18 58734382 58734450 69 + 0.066 0.214 1.966
ENSG00000172175 E028 0.5117739 0.022527367 0.61641151   18 58734451 58734566 116 + 0.123 0.214 0.964
ENSG00000172175 E029 33.9919624 0.001130597 0.13633380 0.34190082 18 58735202 58735329 128 + 1.471 1.391 -0.277
ENSG00000172175 E030 0.4929928 0.023083413 0.61617857   18 58737768 58737926 159 + 0.123 0.214 0.966
ENSG00000172175 E031 0.3206185 0.027442404 1.00000000   18 58741431 58741864 434 + 0.123 0.000 -10.182
ENSG00000172175 E032 33.3865544 0.001068083 0.60258856 0.77193804 18 58741865 58742014 150 + 1.451 1.444 -0.027
ENSG00000172175 E033 31.6384001 0.002577223 0.18587190 0.41166613 18 58744338 58744495 158 + 1.441 1.368 -0.253
ENSG00000172175 E034 33.6733961 0.011509279 0.47488349 0.68349979 18 58745666 58745791 126 + 1.454 1.417 -0.129
ENSG00000172175 E035 0.0000000       18 58745792 58745792 1 +      
ENSG00000172175 E036 224.1688429 0.008696928 0.01718931 0.08613830 18 58747405 58754477 7073 + 2.235 2.352 0.392