ENSG00000172071

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303236 ENSG00000172071 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF2AK3 protein_coding protein_coding 6.291765 3.266113 8.896164 0.7032415 0.1502689 1.442819 2.5763665 1.0158392 3.54098031 0.3687882 0.44771989 1.7914127 0.35052083 0.29020000 0.39946667 0.10926667 6.989069e-01 2.18678e-11 FALSE TRUE
ENST00000415570 ENSG00000172071 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF2AK3 protein_coding processed_transcript 6.291765 3.266113 8.896164 0.7032415 0.1502689 1.442819 0.7588230 0.0000000 1.46725183 0.0000000 0.10285166 7.2067720 0.08342917 0.00000000 0.16503333 0.16503333 1.281185e-09 2.18678e-11 FALSE TRUE
ENST00000668866 ENSG00000172071 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF2AK3 protein_coding processed_transcript 6.291765 3.266113 8.896164 0.7032415 0.1502689 1.442819 0.3669890 0.7740205 0.09824079 0.1650705 0.04006782 -2.8566471 0.08704167 0.23806667 0.01090000 -0.22716667 2.186780e-11 2.18678e-11   FALSE
ENST00000682103 ENSG00000172071 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF2AK3 protein_coding nonsense_mediated_decay 6.291765 3.266113 8.896164 0.7032415 0.1502689 1.442819 0.3803985 0.5144625 0.34229087 0.5144625 0.02193799 -0.5740724 0.09145000 0.11686667 0.03843333 -0.07843333 8.350543e-01 2.18678e-11 TRUE TRUE
ENST00000682276 ENSG00000172071 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF2AK3 protein_coding processed_transcript 6.291765 3.266113 8.896164 0.7032415 0.1502689 1.442819 0.5958722 0.3543481 0.96222102 0.1772850 0.51721976 1.4159670 0.09626250 0.14213333 0.10750000 -0.03463333 9.902805e-01 2.18678e-11 FALSE TRUE
ENST00000684455 ENSG00000172071 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF2AK3 protein_coding nonsense_mediated_decay 6.291765 3.266113 8.896164 0.7032415 0.1502689 1.442819 0.9397777 0.2449056 1.89203863 0.2449056 0.68025016 2.8995113 0.15769583 0.07166667 0.21183333 0.14016667 4.587425e-01 2.18678e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172071 E001 0.0000000       2 88556741 88556745 5 -      
ENSG00000172071 E002 0.1308682 0.030746302 1.932916e-01   2 88556746 88556764 19 - 0.000 0.184 13.097
ENSG00000172071 E003 0.1308682 0.030746302 1.932916e-01   2 88556765 88556768 4 - 0.000 0.184 13.115
ENSG00000172071 E004 1.5085872 0.056233440 3.412531e-01 5.792078e-01 2 88556769 88556809 41 - 0.297 0.497 1.125
ENSG00000172071 E005 13.6622206 0.475647828 3.825702e-01 6.143022e-01 2 88556810 88556930 121 - 1.031 1.296 0.948
ENSG00000172071 E006 11.7894835 0.397590124 3.658651e-01 6.006603e-01 2 88556931 88556934 4 - 0.982 1.225 0.877
ENSG00000172071 E007 11.9922177 0.406789356 3.504271e-01 5.876410e-01 2 88556935 88556940 6 - 0.982 1.241 0.933
ENSG00000172071 E008 98.4673902 1.225271635 3.885480e-01 6.192984e-01 2 88556941 88557853 913 - 1.864 2.117 0.850
ENSG00000172071 E009 26.7184721 0.530308795 3.120163e-01 5.523390e-01 2 88557854 88557936 83 - 1.337 1.523 0.644
ENSG00000172071 E010 1.5539852 0.012198908 4.512097e-01 6.665002e-01 2 88557937 88558916 980 - 0.338 0.494 0.845
ENSG00000172071 E011 21.7161276 0.082102876 1.934732e-01 4.214469e-01 2 88558917 88558979 63 - 1.257 1.431 0.603
ENSG00000172071 E012 3.9083400 0.100068462 7.428375e-01 8.622282e-01 2 88558980 88561336 2357 - 0.621 0.718 0.414
ENSG00000172071 E013 18.5230809 0.002285193 7.701727e-01 8.787322e-01 2 88562289 88562344 56 - 1.233 1.291 0.204
ENSG00000172071 E014 23.6063355 0.003933537 6.300252e-01 7.904264e-01 2 88562345 88562390 46 - 1.323 1.395 0.252
ENSG00000172071 E015 5.8723504 0.427774222 8.526936e-01 9.265227e-01 2 88562391 88565361 2971 - 0.735 0.922 0.732
ENSG00000172071 E016 0.8793906 0.159163133 5.727303e-01   2 88570017 88570873 857 - 0.294 0.183 -0.887
ENSG00000172071 E017 30.0009108 0.001284978 9.994271e-01 1.000000e+00 2 88570874 88570919 46 - 1.436 1.471 0.121
ENSG00000172071 E018 40.2114156 0.006040627 9.237737e-01 9.642698e-01 2 88570920 88571041 122 - 1.559 1.599 0.137
ENSG00000172071 E019 0.4702677 0.022481033 8.676867e-01   2 88571042 88571396 355 - 0.144 0.184 0.428
ENSG00000172071 E020 59.1197629 0.830061203 4.591353e-01 6.725586e-01 2 88574666 88575077 412 - 1.695 1.815 0.408
ENSG00000172071 E021 43.6100920 0.746720761 5.332094e-01 7.243460e-01 2 88575078 88575360 283 - 1.586 1.641 0.185
ENSG00000172071 E022 27.3794749 0.582465483 4.628113e-01 6.750116e-01 2 88575361 88575446 86 - 1.379 1.472 0.320
ENSG00000172071 E023 30.7908715 0.001524425 2.639750e-01 5.032219e-01 2 88576554 88576703 150 - 1.475 1.431 -0.152
ENSG00000172071 E024 30.4916213 0.031718314 1.915651e-01 4.188510e-01 2 88579518 88579640 123 - 1.480 1.381 -0.342
ENSG00000172071 E025 1.7279752 0.011807101 1.177132e-01 3.120430e-01 2 88579641 88581581 1941 - 0.472 0.185 -1.889
ENSG00000172071 E026 29.6973085 0.011765334 5.886020e-04 6.478589e-03 2 88583430 88583542 113 - 1.502 1.227 -0.954
ENSG00000172071 E027 42.1099885 0.035698200 2.903609e-03 2.282171e-02 2 88585841 88586061 221 - 1.649 1.371 -0.953
ENSG00000172071 E028 24.3690956 0.076711023 4.931894e-02 1.779558e-01 2 88587982 88588104 123 - 1.415 1.171 -0.857
ENSG00000172071 E029 25.3909315 0.084277094 7.022596e-02 2.252185e-01 2 88588761 88588832 72 - 1.429 1.191 -0.831
ENSG00000172071 E030 23.0623383 0.052253312 5.416677e-02 1.894738e-01 2 88588833 88588891 59 - 1.381 1.172 -0.731
ENSG00000172071 E031 14.1261362 0.040604661 8.325165e-03 5.081424e-02 2 88588892 88588901 10 - 1.202 0.869 -1.223
ENSG00000172071 E032 36.0995707 0.055520585 5.352553e-02 1.879294e-01 2 88590443 88590605 163 - 1.568 1.367 -0.690
ENSG00000172071 E033 46.8864874 0.027692959 1.314002e-02 7.101642e-02 2 88590818 88591008 191 - 1.678 1.480 -0.677
ENSG00000172071 E034 22.6746158 0.019580913 1.093790e-01 2.980929e-01 2 88591009 88591052 44 - 1.358 1.229 -0.454
ENSG00000172071 E035 0.1614157 0.032250140 1.000000e+00   2 88593017 88593114 98 - 0.078 0.000 -10.291
ENSG00000172071 E036 35.6432418 0.032482257 2.096298e-02 9.922229e-02 2 88593272 88593405 134 - 1.565 1.355 -0.721
ENSG00000172071 E037 0.0000000       2 88593406 88593912 507 -      
ENSG00000172071 E038 0.4868358 0.534736838 9.264564e-01   2 88593913 88594108 196 - 0.148 0.180 0.342
ENSG00000172071 E039 0.1779838 0.084414917 1.000000e+00   2 88594109 88595229 1121 - 0.078 0.000 -10.295
ENSG00000172071 E040 31.6476036 0.065950930 1.816589e-01 4.061663e-01 2 88595469 88595619 151 - 1.502 1.355 -0.506
ENSG00000172071 E041 14.7537617 0.099498130 4.604406e-01 6.734559e-01 2 88595620 88595663 44 - 1.172 1.083 -0.320
ENSG00000172071 E042 0.0000000       2 88595751 88595857 107 -      
ENSG00000172071 E043 18.6083425 0.045543369 2.457811e-01 4.833231e-01 2 88613724 88613853 130 - 1.270 1.169 -0.357
ENSG00000172071 E044 0.8203656 0.567374428 2.660842e-02   2 88624746 88624929 184 - 0.000 0.565 15.452
ENSG00000172071 E045 9.2243542 0.076646043 7.588504e-01 8.718465e-01 2 88626967 88627024 58 - 0.961 0.974 0.049
ENSG00000172071 E046 4.8052129 0.051076343 9.840657e-01 9.938566e-01 2 88627025 88627148 124 - 0.712 0.758 0.189
ENSG00000172071 E047 9.9762343 0.006442269 4.232524e-01 6.460479e-01 2 88627149 88627464 316 - 0.957 1.083 0.464
ENSG00000172071 E048 2.0467202 0.194058939 2.416996e-01 4.784787e-01 2 88685170 88686997 1828 - 0.344 0.624 1.412
ENSG00000172071 E049 0.0000000       2 88686998 88687006 9 -      
ENSG00000172071 E050 1.1733692 0.014657117 1.921788e-03   2 88687007 88687526 520 - 0.078 0.621 4.018
ENSG00000172071 E051 1.6233079 0.835369004 1.449321e-01 3.548609e-01 2 88687527 88688144 618 - 0.149 0.699 3.287
ENSG00000172071 E052 0.1426347 0.031496368 1.000000e+00   2 88688145 88688308 164 - 0.078 0.000 -10.289
ENSG00000172071 E053 9.3763781 0.023590097 3.668092e-13 4.084763e-11 2 88690177 88690754 578 - 0.441 1.418 3.836
ENSG00000172071 E054 8.4769392 0.003947097 5.155689e-19 1.312676e-16 2 88690755 88691175 421 - 0.338 1.413 4.401
ENSG00000172071 E055 3.2003104 0.158149614 1.452246e-04 2.042272e-03 2 88691176 88691315 140 - 0.199 1.001 3.957
ENSG00000172071 E056 0.8209858 0.018458215 1.875592e-02   2 88691316 88691318 3 - 0.078 0.494 3.434
ENSG00000172071 E057 1.7674905 0.010661879 1.839892e-02 9.034958e-02 2 88691319 88691395 77 - 0.252 0.673 2.239
ENSG00000172071 E058 2.1122392 0.011069475 3.036658e-03 2.363087e-02 2 88691396 88691437 42 - 0.252 0.761 2.603
ENSG00000172071 E059 1.7674905 0.010661879 1.839892e-02 9.034958e-02 2 88691438 88691442 5 - 0.252 0.673 2.239
ENSG00000172071 E060 1.6366223 0.011584747 4.309183e-02 1.628220e-01 2 88691443 88691518 76 - 0.252 0.621 2.018