ENSG00000172046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398888 ENSG00000172046 HEK293_OSMI2_6hA HEK293_TMG_6hB USP19 protein_coding protein_coding 53.71408 83.45066 38.85289 8.541607 1.719662 -1.102703 6.008493 9.551896 4.915800 0.7469688 0.6318123 -0.9569388 0.10573333 0.11536667 0.12833333 0.0129666667 9.527009e-01 7.190279e-25 FALSE TRUE
ENST00000417901 ENSG00000172046 HEK293_OSMI2_6hA HEK293_TMG_6hB USP19 protein_coding protein_coding 53.71408 83.45066 38.85289 8.541607 1.719662 -1.102703 14.359259 21.861179 12.590877 4.4137202 1.1391798 -0.7955068 0.27354583 0.25653333 0.32396667 0.0674333333 6.851998e-01 7.190279e-25 FALSE TRUE
ENST00000483667 ENSG00000172046 HEK293_OSMI2_6hA HEK293_TMG_6hB USP19 protein_coding processed_transcript 53.71408 83.45066 38.85289 8.541607 1.719662 -1.102703 9.897115 12.848466 6.580268 2.0824148 0.5646068 -0.9643095 0.18177083 0.16016667 0.16880000 0.0086333333 9.565066e-01 7.190279e-25 FALSE FALSE
ENST00000691288 ENSG00000172046 HEK293_OSMI2_6hA HEK293_TMG_6hB USP19 protein_coding protein_coding 53.71408 83.45066 38.85289 8.541607 1.719662 -1.102703 4.453451 6.457886 3.233071 1.2212130 0.6084427 -0.9959338 0.08484583 0.08173333 0.08216667 0.0004333333 9.893250e-01 7.190279e-25 FALSE TRUE
MSTRG.22945.18 ENSG00000172046 HEK293_OSMI2_6hA HEK293_TMG_6hB USP19 protein_coding   53.71408 83.45066 38.85289 8.541607 1.719662 -1.102703 2.297473 2.255859 3.305758 0.3829942 0.2326424 0.5492806 0.04921667 0.02826667 0.08493333 0.0566666667 9.197813e-03 7.190279e-25 FALSE TRUE
MSTRG.22945.7 ENSG00000172046 HEK293_OSMI2_6hA HEK293_TMG_6hB USP19 protein_coding   53.71408 83.45066 38.85289 8.541607 1.719662 -1.102703 7.335100 12.149288 3.665487 2.8713365 0.7100868 -1.7260515 0.13300417 0.14146667 0.09630000 -0.0451666667 7.007290e-01 7.190279e-25 FALSE TRUE
MSTRG.22945.8 ENSG00000172046 HEK293_OSMI2_6hA HEK293_TMG_6hB USP19 protein_coding   53.71408 83.45066 38.85289 8.541607 1.719662 -1.102703 2.138687 5.802667 0.000000 0.5390140 0.0000000 -9.1830566 0.03422917 0.06983333 0.00000000 -0.0698333333 7.190279e-25 7.190279e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172046 E001 0.3032425 0.0274424043 6.638737e-01   3 49108046 49108049 4 - 0.000 0.141 8.541
ENSG00000172046 E002 2.7209943 0.0879184974 2.090136e-01 4.406913e-01 3 49108050 49108057 8 - 0.317 0.589 1.423
ENSG00000172046 E003 6.5951347 0.0115841144 7.243511e-01 8.507565e-01 3 49108058 49108088 31 - 0.874 0.829 -0.174
ENSG00000172046 E004 31.1356070 0.0174354406 5.586414e-01 7.422866e-01 3 49108089 49108130 42 - 1.403 1.466 0.216
ENSG00000172046 E005 36.1351931 0.0128250998 5.549874e-01 7.397814e-01 3 49108131 49108156 26 - 1.472 1.528 0.192
ENSG00000172046 E006 72.0484539 0.0163378385 3.325668e-01 5.712991e-01 3 49108157 49108163 7 - 1.858 1.791 -0.224
ENSG00000172046 E007 564.0161000 0.0004709264 1.017821e-06 2.887560e-05 3 49108164 49108528 365 - 2.624 2.720 0.322
ENSG00000172046 E008 7.0438642 0.2524096930 1.265768e-01 3.263692e-01 3 49108673 49108674 2 - 1.067 0.752 -1.201
ENSG00000172046 E009 17.5658094 0.1052479286 5.302078e-01 7.222208e-01 3 49108675 49108698 24 - 1.279 1.190 -0.311
ENSG00000172046 E010 20.3023918 0.0789644852 6.963311e-01 8.331668e-01 3 49108699 49108712 14 - 1.316 1.259 -0.200
ENSG00000172046 E011 42.6983839 0.0151403049 9.384099e-01 9.714931e-01 3 49108713 49108752 40 - 1.584 1.585 0.001
ENSG00000172046 E012 46.7670455 0.0085820481 6.215279e-01 7.848591e-01 3 49108753 49108786 34 - 1.602 1.632 0.103
ENSG00000172046 E013 41.9861374 0.0010005653 6.184896e-01 7.827946e-01 3 49108787 49108801 15 - 1.558 1.586 0.098
ENSG00000172046 E014 48.0880141 0.0012871730 4.674124e-01 6.783406e-01 3 49108802 49108832 31 - 1.607 1.647 0.137
ENSG00000172046 E015 104.1538474 0.0054150742 2.313593e-01 4.666996e-01 3 49108833 49108961 129 - 1.922 1.981 0.197
ENSG00000172046 E016 162.3727979 0.0054614316 2.189732e-02 1.022397e-01 3 49108962 49109185 224 - 2.075 2.183 0.359
ENSG00000172046 E017 33.3926965 0.0775828874 9.272531e-03 5.498423e-02 3 49109739 49109754 16 - 1.721 1.350 -1.271
ENSG00000172046 E018 58.6574806 0.0911283679 5.535541e-02 1.921397e-01 3 49109755 49109869 115 - 1.901 1.632 -0.908
ENSG00000172046 E019 55.6766509 0.1012690990 1.944081e-01 4.226187e-01 3 49110013 49110183 171 - 1.821 1.644 -0.599
ENSG00000172046 E020 638.7012965 0.0001632298 7.599306e-13 7.946657e-11 3 49110184 49110355 172 - 2.659 2.781 0.407
ENSG00000172046 E021 303.5930221 0.0001616750 7.917700e-04 8.212347e-03 3 49110356 49110362 7 - 2.370 2.449 0.263
ENSG00000172046 E022 284.1890357 0.0001670556 5.055570e-05 8.398240e-04 3 49110444 49110447 4 - 2.324 2.424 0.332
ENSG00000172046 E023 652.1532540 0.0001583955 4.132633e-05 7.076186e-04 3 49110448 49110604 157 - 2.709 2.776 0.223
ENSG00000172046 E024 575.6193622 0.0001791083 8.095407e-04 8.360413e-03 3 49110711 49110863 153 - 2.662 2.720 0.193
ENSG00000172046 E025 581.4733657 0.0008408441 2.100830e-03 1.774284e-02 3 49110950 49111166 217 - 2.660 2.726 0.219
ENSG00000172046 E026 377.7975357 0.0003833912 9.874031e-03 5.758610e-02 3 49111255 49111365 111 - 2.481 2.539 0.191
ENSG00000172046 E027 696.5716736 0.0007439826 3.935915e-01 6.232153e-01 3 49111500 49111813 314 - 2.777 2.792 0.051
ENSG00000172046 E028 473.8562704 0.0002357132 6.282852e-01 7.894438e-01 3 49111911 49112048 138 - 2.616 2.624 0.026
ENSG00000172046 E029 401.6133252 0.0014173951 3.269705e-01 5.661123e-01 3 49112284 49112402 119 - 2.531 2.553 0.074
ENSG00000172046 E030 380.0851608 0.0001408933 2.338229e-01 4.695786e-01 3 49112489 49112629 141 - 2.509 2.532 0.078
ENSG00000172046 E031 387.2214175 0.0001650606 9.302101e-01 9.671014e-01 3 49113992 49114093 102 - 2.536 2.533 -0.012
ENSG00000172046 E032 441.9942719 0.0018589125 6.434046e-01 7.991232e-01 3 49114174 49114284 111 - 2.603 2.586 -0.056
ENSG00000172046 E033 471.0132961 0.0011678958 2.260291e-01 4.606261e-01 3 49114763 49114873 111 - 2.642 2.610 -0.107
ENSG00000172046 E034 554.4835075 0.0011274100 3.346650e-02 1.373826e-01 3 49114959 49115117 159 - 2.726 2.674 -0.172
ENSG00000172046 E035 532.7853598 0.0001260224 2.153447e-05 4.068812e-04 3 49115228 49115361 134 - 2.726 2.651 -0.249
ENSG00000172046 E036 609.1302388 0.0001549671 6.517344e-07 1.957889e-05 3 49115444 49115639 196 - 2.791 2.707 -0.277
ENSG00000172046 E037 525.4685482 0.0004508013 2.027987e-03 1.724648e-02 3 49115724 49115938 215 - 2.711 2.648 -0.211
ENSG00000172046 E038 92.7771123 0.0008985735 2.475138e-01 4.852944e-01 3 49115939 49115944 6 - 1.952 1.900 -0.175
ENSG00000172046 E039 138.2930405 0.0003466244 4.203828e-01 6.439365e-01 3 49116047 49116047 1 - 2.069 2.095 0.089
ENSG00000172046 E040 318.0915713 0.0004362898 3.216229e-01 5.611384e-01 3 49116048 49116162 115 - 2.432 2.453 0.071
ENSG00000172046 E041 288.4984522 0.0001870908 4.484793e-01 6.645792e-01 3 49116280 49116351 72 - 2.422 2.402 -0.066
ENSG00000172046 E042 498.3895070 0.0003487038 3.285496e-03 2.510474e-02 3 49116451 49116607 157 - 2.686 2.627 -0.197
ENSG00000172046 E043 21.6118565 0.0537930669 1.124567e-01 3.032300e-01 3 49116721 49116726 6 - 1.451 1.235 -0.755
ENSG00000172046 E044 530.9392118 0.0001262340 3.114743e-02 1.307741e-01 3 49116727 49116943 217 - 2.700 2.661 -0.131
ENSG00000172046 E045 238.1723693 0.0035959186 3.013049e-02 1.277233e-01 3 49117059 49117208 150 - 2.257 2.344 0.291
ENSG00000172046 E046 216.6203676 0.0016861924 7.346398e-02 2.317003e-01 3 49117209 49117358 150 - 2.238 2.297 0.195
ENSG00000172046 E047 91.0167965 0.0005025618 5.404010e-02 1.891664e-01 3 49117359 49117361 3 - 1.970 1.889 -0.272
ENSG00000172046 E048 175.7710992 0.0003549059 9.188207e-01 9.616176e-01 3 49117437 49117466 30 - 2.193 2.194 0.004
ENSG00000172046 E049 266.4605448 0.0034905217 4.835416e-01 6.894749e-01 3 49117467 49117570 104 - 2.357 2.376 0.063
ENSG00000172046 E050 332.3126734 0.0014920499 3.486066e-02 1.412517e-01 3 49117657 49117785 129 - 2.514 2.448 -0.218
ENSG00000172046 E051 189.3276661 0.0019903261 1.574481e-03 1.413977e-02 3 49117786 49117830 45 - 2.306 2.189 -0.389
ENSG00000172046 E052 428.9037208 0.0002416075 3.799270e-15 5.897655e-13 3 49117947 49118120 174 - 2.686 2.531 -0.516
ENSG00000172046 E053 473.6835852 0.0001858026 1.076565e-03 1.050359e-02 3 49119022 49119281 260 - 2.668 2.606 -0.209
ENSG00000172046 E054 15.6656606 0.0048242709 7.974505e-01 8.948660e-01 3 49120468 49120755 288 - 1.161 1.187 0.093
ENSG00000172046 E055 167.7615669 0.0002980102 1.227868e-01 3.201350e-01 3 49120756 49120949 194 - 2.137 2.185 0.160