ENSG00000172009

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000585673 ENSG00000172009 HEK293_OSMI2_6hA HEK293_TMG_6hB THOP1 protein_coding processed_transcript 155.6955 232.9298 81.83675 45.83085 2.237039 -1.50896 33.97261 51.23933 19.22567 13.8984252 1.032380 -1.4137493 0.22337917 0.21146667 0.2350000 0.02353333 8.825469e-01 1.602141e-15 FALSE TRUE
ENST00000586677 ENSG00000172009 HEK293_OSMI2_6hA HEK293_TMG_6hB THOP1 protein_coding protein_coding 155.6955 232.9298 81.83675 45.83085 2.237039 -1.50896 14.15312 29.94891 0.00000 10.9399452 0.000000 -11.5487695 0.05735417 0.11746667 0.0000000 -0.11746667 1.602141e-15 1.602141e-15 FALSE TRUE
MSTRG.16137.3 ENSG00000172009 HEK293_OSMI2_6hA HEK293_TMG_6hB THOP1 protein_coding   155.6955 232.9298 81.83675 45.83085 2.237039 -1.50896 31.00969 46.60613 12.89538 9.1518226 2.021698 -1.8528566 0.19433333 0.20143333 0.1588000 -0.04263333 7.223644e-01 1.602141e-15 TRUE TRUE
MSTRG.16137.8 ENSG00000172009 HEK293_OSMI2_6hA HEK293_TMG_6hB THOP1 protein_coding   155.6955 232.9298 81.83675 45.83085 2.237039 -1.50896 11.06208 15.84454 11.15764 0.6072632 1.462462 -0.5055715 0.08811667 0.07513333 0.1355667 0.06043333 3.367999e-01 1.602141e-15 FALSE TRUE
MSTRG.16137.9 ENSG00000172009 HEK293_OSMI2_6hA HEK293_TMG_6hB THOP1 protein_coding   155.6955 232.9298 81.83675 45.83085 2.237039 -1.50896 39.22525 53.73656 20.10764 11.8885813 3.001812 -1.4177116 0.25128750 0.22763333 0.2443667 0.01673333 9.598537e-01 1.602141e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000172009 E001 3.225253 7.878597e-03 1.721616e-01 3.933985e-01 19 2785478 2785501 24 + 0.354 0.616 1.314
ENSG00000172009 E002 7.149169 4.464616e-03 9.508903e-03 5.600633e-02 19 2785502 2785502 1 + 0.461 0.899 1.875
ENSG00000172009 E003 7.464178 4.966064e-03 2.456200e-02 1.108872e-01 19 2785503 2785503 1 + 0.546 0.908 1.495
ENSG00000172009 E004 25.374073 9.755633e-02 1.205562e-03 1.147306e-02 19 2785504 2785513 10 + 0.817 1.405 2.135
ENSG00000172009 E005 101.003980 2.978575e-03 4.405243e-04 5.132136e-03 19 2785514 2785547 34 + 1.766 1.955 0.638
ENSG00000172009 E006 175.849136 2.404631e-03 7.328797e-05 1.154009e-03 19 2785548 2785566 19 + 2.021 2.190 0.568
ENSG00000172009 E007 403.729813 3.477174e-04 4.725446e-04 5.425892e-03 19 2785567 2785678 112 + 2.455 2.536 0.270
ENSG00000172009 E008 9.184373 4.461496e-02 7.837314e-01 8.868134e-01 19 2786949 2787034 86 + 0.964 0.905 -0.220
ENSG00000172009 E009 716.042628 1.243959e-04 1.314420e-01 3.340697e-01 19 2790421 2790554 134 + 2.789 2.762 -0.091
ENSG00000172009 E010 743.456457 7.741826e-04 1.167189e-08 5.387756e-07 19 2790555 2790633 79 + 2.872 2.753 -0.397
ENSG00000172009 E011 540.254911 1.339425e-04 3.849495e-12 3.586583e-10 19 2794764 2794792 29 + 2.744 2.616 -0.426
ENSG00000172009 E012 1019.786447 1.052618e-04 6.287692e-18 1.427533e-15 19 2794793 2794912 120 + 3.011 2.894 -0.392
ENSG00000172009 E013 1.665697 6.082465e-02 2.612378e-01 5.002671e-01 19 2796007 2796080 74 + 0.545 0.331 -1.133
ENSG00000172009 E014 991.131886 1.308376e-04 4.349101e-11 3.322436e-09 19 2796081 2796188 108 + 2.981 2.887 -0.311
ENSG00000172009 E015 932.717304 1.053117e-04 1.176271e-04 1.710989e-03 19 2799689 2799791 103 + 2.927 2.869 -0.192
ENSG00000172009 E016 12.128868 1.091141e-01 2.305520e-02 1.061288e-01 19 2804611 2804656 46 + 1.324 0.907 -1.506
ENSG00000172009 E017 1131.094671 7.204665e-05 7.462673e-03 4.684805e-02 19 2805016 2805176 161 + 2.995 2.959 -0.122
ENSG00000172009 E018 52.638230 1.541355e-01 1.320903e-02 7.128729e-02 19 2806017 2806916 900 + 1.960 1.494 -1.578
ENSG00000172009 E019 820.318310 9.170491e-05 2.713336e-01 5.112823e-01 19 2806917 2806984 68 + 2.842 2.824 -0.063
ENSG00000172009 E020 829.250733 3.798174e-04 9.844926e-01 9.940986e-01 19 2806985 2807052 68 + 2.834 2.830 -0.014
ENSG00000172009 E021 844.826627 2.193653e-04 9.059141e-02 2.648642e-01 19 2807442 2807571 130 + 2.820 2.844 0.080
ENSG00000172009 E022 646.795736 2.568492e-04 2.350185e-03 1.937642e-02 19 2807572 2807685 114 + 2.679 2.734 0.180
ENSG00000172009 E023 581.882221 2.814813e-04 1.285109e-05 2.607731e-04 19 2807686 2807773 88 + 2.609 2.693 0.282
ENSG00000172009 E024 341.967063 1.860632e-04 1.431329e-05 2.859340e-04 19 2807774 2807780 7 + 2.362 2.469 0.356
ENSG00000172009 E025 401.820912 1.606150e-04 1.999118e-06 5.220608e-05 19 2807781 2807808 28 + 2.430 2.538 0.359
ENSG00000172009 E026 136.185506 5.529741e-02 2.036480e-01 4.341153e-01 19 2807809 2808242 434 + 2.172 2.005 -0.559
ENSG00000172009 E027 695.182849 3.230736e-04 9.232090e-11 6.595798e-09 19 2808243 2808357 115 + 2.658 2.778 0.400
ENSG00000172009 E028 673.572421 1.581577e-04 2.359401e-09 1.280948e-07 19 2808358 2808444 87 + 2.657 2.763 0.352
ENSG00000172009 E029 46.044959 9.006745e-02 3.036756e-02 1.284557e-01 19 2808818 2808890 73 + 1.826 1.487 -1.153
ENSG00000172009 E030 65.267990 4.868706e-02 4.018024e-03 2.926794e-02 19 2809538 2809806 269 + 1.985 1.630 -1.200
ENSG00000172009 E031 31.590004 8.040025e-02 7.998550e-02 2.448029e-01 19 2809807 2809845 39 + 1.623 1.353 -0.928
ENSG00000172009 E032 68.632695 8.768262e-02 3.808408e-02 1.498472e-01 19 2809846 2810098 253 + 1.980 1.667 -1.055
ENSG00000172009 E033 19.365784 1.848775e-01 1.498399e-01 3.620595e-01 19 2810099 2810152 54 + 1.429 1.148 -0.986
ENSG00000172009 E034 34.690057 6.219481e-02 1.465351e-01 3.572304e-01 19 2810153 2810303 151 + 1.634 1.403 -0.791
ENSG00000172009 E035 986.398276 5.924031e-04 3.503837e-03 2.636852e-02 19 2810304 2810490 187 + 2.867 2.915 0.160
ENSG00000172009 E036 29.622234 6.118629e-02 4.098273e-01 6.358604e-01 19 2810491 2810639 149 + 1.494 1.366 -0.442
ENSG00000172009 E037 477.855298 1.461504e-04 9.763110e-02 2.776523e-01 19 2810640 2810662 23 + 2.568 2.600 0.106
ENSG00000172009 E038 924.445905 9.641145e-04 4.098163e-01 6.358492e-01 19 2810663 2810768 106 + 2.865 2.877 0.041
ENSG00000172009 E039 684.031087 5.607651e-04 8.717107e-02 2.585739e-01 19 2811598 2811633 36 + 2.721 2.752 0.102
ENSG00000172009 E040 957.754114 6.054858e-04 9.857655e-02 2.793196e-01 19 2811634 2811734 101 + 2.872 2.895 0.076
ENSG00000172009 E041 10.121617 2.068762e-01 6.514253e-01 8.044577e-01 19 2811864 2811954 91 + 0.865 0.983 0.447
ENSG00000172009 E042 17.519350 1.329542e-01 4.781585e-01 6.858999e-01 19 2812027 2812188 162 + 1.308 1.139 -0.599
ENSG00000172009 E043 19.113620 9.479778e-02 7.862347e-01 8.882551e-01 19 2812199 2812372 174 + 1.261 1.199 -0.220
ENSG00000172009 E044 1383.483933 7.449447e-04 2.294386e-06 5.884017e-05 19 2813115 2813495 381 + 2.989 3.064 0.249
ENSG00000172009 E045 335.641965 1.863204e-04 2.485624e-01 4.863403e-01 19 2813496 2815807 2312 + 2.418 2.444 0.086