ENSG00000171988

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327520 ENSG00000171988 HEK293_OSMI2_6hA HEK293_TMG_6hB JMJD1C protein_coding protein_coding 4.654972 1.842141 9.342368 0.2569539 0.08768694 2.336138 0.2718560 0.07872487 0.7112287 0.02453759 0.1075473 3.0230462 0.05571667 0.04843333 0.07636667 0.02793333 0.7912317929 0.0008049815 FALSE TRUE
ENST00000399262 ENSG00000171988 HEK293_OSMI2_6hA HEK293_TMG_6hB JMJD1C protein_coding protein_coding 4.654972 1.842141 9.342368 0.2569539 0.08768694 2.336138 0.4497628 0.17670085 0.6386201 0.02252131 0.1551960 1.7966453 0.09901667 0.09660000 0.06826667 -0.02833333 0.7688535121 0.0008049815 FALSE TRUE
ENST00000467356 ENSG00000171988 HEK293_OSMI2_6hA HEK293_TMG_6hB JMJD1C protein_coding retained_intron 4.654972 1.842141 9.342368 0.2569539 0.08768694 2.336138 0.9769516 0.86623916 1.5159329 0.16622584 0.2108888 0.8002949 0.35440833 0.46643333 0.16260000 -0.30383333 0.0009839782 0.0008049815   FALSE
ENST00000542921 ENSG00000171988 HEK293_OSMI2_6hA HEK293_TMG_6hB JMJD1C protein_coding protein_coding 4.654972 1.842141 9.342368 0.2569539 0.08768694 2.336138 0.3358829 0.00000000 0.9782067 0.00000000 0.1835000 6.6267409 0.04100833 0.00000000 0.10446667 0.10446667 0.0008049815 0.0008049815 FALSE TRUE
MSTRG.4045.1 ENSG00000171988 HEK293_OSMI2_6hA HEK293_TMG_6hB JMJD1C protein_coding   4.654972 1.842141 9.342368 0.2569539 0.08768694 2.336138 0.7099688 0.11322384 1.2353036 0.11322384 0.1990654 3.3371442 0.11711250 0.08240000 0.13253333 0.05013333 0.5900157380 0.0008049815 FALSE TRUE
MSTRG.4045.5 ENSG00000171988 HEK293_OSMI2_6hA HEK293_TMG_6hB JMJD1C protein_coding   4.654972 1.842141 9.342368 0.2569539 0.08768694 2.336138 1.1981140 0.27983737 2.4558852 0.27983737 0.7118049 3.0887901 0.17115833 0.14793333 0.26166667 0.11373333 0.5257458938 0.0008049815 FALSE TRUE
MSTRG.4045.7 ENSG00000171988 HEK293_OSMI2_6hA HEK293_TMG_6hB JMJD1C protein_coding   4.654972 1.842141 9.342368 0.2569539 0.08768694 2.336138 0.5406522 0.25040456 1.2435340 0.25040456 0.4352957 2.2671746 0.12395000 0.11080000 0.13393333 0.02313333 0.7006305779 0.0008049815 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171988 E001 0.0000000       10 63167221 63167224 4 -      
ENSG00000171988 E002 0.6765862 0.2142168399 6.765897e-01   10 63167225 63167347 123 - 0.195 0.001 -8.491
ENSG00000171988 E003 19.1060196 0.0398037618 2.936594e-02 0.1254725794 10 63167348 63167589 242 - 1.119 1.384 0.934
ENSG00000171988 E004 22.8765181 0.0084651145 5.061540e-04 0.0057354103 10 63167590 63167702 113 - 1.176 1.490 1.095
ENSG00000171988 E005 75.8906116 0.0005171539 4.536825e-05 0.0007658620 10 63167703 63168109 407 - 1.714 1.911 0.665
ENSG00000171988 E006 24.7215181 0.0022832515 5.429552e-01 0.7311778548 10 63168110 63168134 25 - 1.272 1.325 0.187
ENSG00000171988 E007 51.3662051 0.0008143958 1.047501e-01 0.2901954032 10 63168435 63168566 132 - 1.568 1.668 0.338
ENSG00000171988 E008 53.8925763 0.0059393296 4.314098e-02 0.1629195953 10 63176297 63176473 177 - 1.578 1.715 0.466
ENSG00000171988 E009 0.9604841 0.0503818869 3.024062e-01   10 63176474 63176555 82 - 0.193 0.397 1.419
ENSG00000171988 E010 10.4719871 0.0541470590 7.992169e-01 0.8958476990 10 63176800 63177716 917 - 0.944 0.887 -0.214
ENSG00000171988 E011 47.6519703 0.0161532391 1.523360e-01 0.3657505361 10 63177717 63177856 140 - 1.530 1.655 0.426
ENSG00000171988 E012 39.9020380 0.0011421740 2.036824e-01 0.4341654436 10 63183447 63183569 123 - 1.467 1.557 0.305
ENSG00000171988 E013 41.0417926 0.0010775975 3.766632e-02 0.1487548415 10 63184608 63184738 131 - 1.467 1.608 0.481
ENSG00000171988 E014 36.3623541 0.0016043282 6.560478e-01 0.8073918470 10 63185563 63185653 91 - 1.435 1.468 0.113
ENSG00000171988 E015 44.1886308 0.0010102383 1.931263e-01 0.4209671453 10 63186215 63186383 169 - 1.505 1.592 0.297
ENSG00000171988 E016 37.1050543 0.0065684070 2.581694e-02 0.1147274748 10 63189168 63189286 119 - 1.411 1.585 0.599
ENSG00000171988 E017 39.3861243 0.0043905364 7.965914e-01 0.8943332766 10 63189287 63189446 160 - 1.477 1.498 0.074
ENSG00000171988 E018 45.7995409 0.0015863808 8.144894e-01 0.9049331672 10 63190894 63191108 215 - 1.541 1.557 0.054
ENSG00000171988 E019 14.4311436 0.0023883202 2.878424e-01 0.5286168614 10 63192938 63192938 1 - 1.043 1.159 0.419
ENSG00000171988 E020 39.8924897 0.0019345413 1.590168e-01 0.3752739869 10 63192939 63193097 159 - 1.467 1.566 0.339
ENSG00000171988 E021 19.1304150 0.0130830067 8.310289e-01 0.9143482136 10 63193098 63193109 12 - 1.180 1.201 0.073
ENSG00000171988 E022 20.1089603 0.0039733104 6.082050e-01 0.7757322309 10 63193110 63193151 42 - 1.213 1.158 -0.194
ENSG00000171988 E023 0.6190593 0.0212631876 6.129511e-01   10 63193152 63193344 193 - 0.152 0.242 0.836
ENSG00000171988 E024 32.1969632 0.0049343494 4.925408e-01 0.6956914645 10 63193345 63193472 128 - 1.404 1.340 -0.221
ENSG00000171988 E025 0.0000000       10 63193473 63193649 177 -      
ENSG00000171988 E026 29.8188448 0.0015653867 1.926812e-01 0.4203658158 10 63194286 63194375 90 - 1.378 1.259 -0.415
ENSG00000171988 E027 0.1426347 0.0319495743 1.000000e+00   10 63194376 63194694 319 - 0.057 0.000 -9.455
ENSG00000171988 E028 39.1485827 0.0009864285 1.831751e-01 0.4080240482 10 63197411 63197563 153 - 1.488 1.382 -0.363
ENSG00000171988 E029 47.3026493 0.0008177971 1.539783e-01 0.3680062078 10 63198513 63198727 215 - 1.570 1.467 -0.351
ENSG00000171988 E030 44.4256815 0.0011092158 5.207241e-01 0.7153965150 10 63200476 63200677 202 - 1.536 1.489 -0.161
ENSG00000171988 E031 211.8770331 0.0006706065 2.936392e-05 0.0005297078 10 63206595 63208801 2207 - 2.217 2.072 -0.486
ENSG00000171988 E032 28.8604777 0.0064491265 3.333497e-01 0.5719481631 10 63209063 63209235 173 - 1.356 1.259 -0.338
ENSG00000171988 E033 112.3852696 0.0104987614 7.645776e-04 0.0079832292 10 63213473 63214723 1251 - 1.954 1.721 -0.786
ENSG00000171988 E034 34.4643610 0.0023715272 4.785807e-02 0.1746776480 10 63214724 63215139 416 - 1.450 1.276 -0.606
ENSG00000171988 E035 7.2906103 0.0132597859 6.305384e-01 0.7907830867 10 63215140 63215151 12 - 0.818 0.738 -0.320
ENSG00000171988 E036 28.4344976 0.0087907188 4.694925e-01 0.6796876314 10 63215263 63215423 161 - 1.349 1.276 -0.255
ENSG00000171988 E037 15.1148112 0.0168468506 6.672530e-01 0.8144651527 10 63215424 63215437 14 - 1.088 1.029 -0.214
ENSG00000171988 E038 14.8570687 0.0239480427 9.431935e-01 0.9739330920 10 63215438 63215455 18 - 1.074 1.058 -0.055
ENSG00000171988 E039 19.5546730 0.0018765517 4.452591e-01 0.6622516898 10 63215553 63215617 65 - 1.195 1.112 -0.297
ENSG00000171988 E040 15.1947060 0.0021324498 5.830277e-01 0.7590316364 10 63215618 63215696 79 - 1.095 1.029 -0.239
ENSG00000171988 E041 15.7932759 0.0021924988 5.456437e-02 0.1903900637 10 63217207 63217331 125 - 1.132 0.887 -0.904
ENSG00000171988 E042 0.0000000       10 63219877 63219877 1 -      
ENSG00000171988 E043 7.4696953 0.0241202760 2.009700e-02 0.0962112122 10 63219878 63219983 106 - 0.862 0.396 -2.076
ENSG00000171988 E044 12.4378492 0.0026159215 3.712568e-03 0.0275426765 10 63264651 63264764 114 - 1.054 0.600 -1.793
ENSG00000171988 E045 5.9495822 0.0047070678 9.697061e-03 0.0568130795 10 63268663 63269253 591 - 0.780 0.242 -2.752
ENSG00000171988 E046 14.4366829 0.0024520301 4.023946e-01 0.6303019619 10 63380318 63380482 165 - 1.043 1.136 0.336
ENSG00000171988 E047 4.0595734 0.1906145843 3.602682e-02 0.1443103552 10 63465495 63465977 483 - 0.486 0.938 1.895
ENSG00000171988 E048 4.5249355 0.0475726847 4.275454e-01 0.6491425092 10 63521738 63521902 165 - 0.594 0.745 0.637