ENSG00000171928

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307767 ENSG00000171928 HEK293_OSMI2_6hA HEK293_TMG_6hB TVP23B protein_coding protein_coding 17.18236 5.052516 28.40126 0.4266238 0.9951636 2.488537 12.8449805 3.4855089 24.2919275 0.66496475 0.51467026 2.7974963 0.69714167 0.6783333 0.85763333 0.17930000 0.3311072223 0.0001914103 FALSE TRUE
ENST00000476139 ENSG00000171928 HEK293_OSMI2_6hA HEK293_TMG_6hB TVP23B protein_coding protein_coding 17.18236 5.052516 28.40126 0.4266238 0.9951636 2.488537 0.6360613 0.6288174 0.8156860 0.05885333 0.08737524 0.3701896 0.05408750 0.1279667 0.02893333 -0.09903333 0.0001914103 0.0001914103 FALSE FALSE
ENST00000575261 ENSG00000171928 HEK293_OSMI2_6hA HEK293_TMG_6hB TVP23B protein_coding protein_coding 17.18236 5.052516 28.40126 0.4266238 0.9951636 2.488537 2.0359683 0.1629949 1.5855684 0.16299488 0.79692173 3.2052692 0.07827917 0.0276000 0.05493333 0.02733333 0.8073515054 0.0001914103 FALSE FALSE
ENST00000581733 ENSG00000171928 HEK293_OSMI2_6hA HEK293_TMG_6hB TVP23B protein_coding protein_coding 17.18236 5.052516 28.40126 0.4266238 0.9951636 2.488537 1.0594989 0.5358895 0.6717513 0.28876107 0.43137590 0.3206366 0.12794167 0.1158667 0.02280000 -0.09306667 0.7915720812 0.0001914103 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171928 E001 0.1426347 0.0316016443 1.0000000000   17 18781111 18781142 32 + 0.064 0.000 -8.415
ENSG00000171928 E002 0.1426347 0.0316016443 1.0000000000   17 18781143 18781154 12 + 0.064 0.000 -10.272
ENSG00000171928 E003 0.2852693 0.2718702387 1.0000000000   17 18781155 18781179 25 + 0.118 0.000 -10.397
ENSG00000171928 E004 0.2852693 0.2718702387 1.0000000000   17 18781180 18781182 3 + 0.118 0.000 -10.397
ENSG00000171928 E005 15.5695094 0.0022312857 0.5828884703 0.758932484 17 18781183 18781286 104 + 1.140 1.086 -0.197
ENSG00000171928 E006 20.9626481 0.0016096871 0.3028109434 0.543384330 17 18781287 18781305 19 + 1.265 1.171 -0.334
ENSG00000171928 E007 13.9492058 0.0405287611 0.0001480911 0.002075194 17 18781314 18782549 1236 + 0.929 1.432 1.797
ENSG00000171928 E008 2.2960903 0.0395708430 0.0283790173 0.122441245 17 18789035 18789051 17 + 0.354 0.747 1.864
ENSG00000171928 E009 23.5326459 0.0020565803 0.5113438515 0.708981042 17 18789353 18789357 5 + 1.283 1.344 0.211
ENSG00000171928 E010 25.9535878 0.0016835536 0.6517836761 0.804645643 17 18789358 18789362 5 + 1.327 1.369 0.144
ENSG00000171928 E011 53.9361193 0.0007300180 0.4210609531 0.644475397 17 18789363 18789435 73 + 1.634 1.684 0.170
ENSG00000171928 E012 0.6129023 0.0191408760 0.7839340335   17 18789436 18789669 234 + 0.169 0.219 0.468
ENSG00000171928 E013 75.0344702 0.0005755313 0.8721759330 0.937113875 17 18790896 18790960 65 + 1.783 1.780 -0.011
ENSG00000171928 E014 91.6483328 0.0006484490 0.6122095971 0.778311433 17 18790961 18791040 80 + 1.872 1.853 -0.062
ENSG00000171928 E015 4.0430914 0.0449126280 0.1066262936 0.293354454 17 18795806 18797578 1773 + 0.565 0.839 1.143
ENSG00000171928 E016 90.3794618 0.0005663006 0.1349740509 0.339666260 17 18797579 18797668 90 + 1.876 1.811 -0.216
ENSG00000171928 E017 117.0362832 0.0004226591 0.7431799691 0.862468260 17 18798812 18798943 132 + 1.974 1.966 -0.028
ENSG00000171928 E018 0.8074543 0.1576153858 1.0000000000   17 18798944 18799131 188 + 0.215 0.218 0.025
ENSG00000171928 E019 85.6750705 0.0006416565 0.3186721116 0.558467881 17 18804138 18804266 129 + 1.828 1.877 0.166
ENSG00000171928 E020 0.1308682 0.0317235599 0.1025513101   17 18804267 18804616 350 + 0.000 0.219 12.116
ENSG00000171928 E021 292.4715229 0.0003127536 0.1360958744 0.341507598 17 18805541 18806714 1174 + 2.373 2.344 -0.096