ENSG00000171914

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000494733 ENSG00000171914 HEK293_OSMI2_6hA HEK293_TMG_6hB TLN2 protein_coding protein_coding 3.272277 5.77275 2.212308 0.4947299 0.1742071 -1.379697 0.8471763 2.1087948 0.0000000 0.29889338 0.0000000 -7.7271001 0.19899167 0.36186667 0.00000000 -0.36186667 5.292749e-13 5.292749e-13 FALSE TRUE
ENST00000561197 ENSG00000171914 HEK293_OSMI2_6hA HEK293_TMG_6hB TLN2 protein_coding processed_transcript 3.272277 5.77275 2.212308 0.4947299 0.1742071 -1.379697 0.2115382 0.1665036 0.1515100 0.08903643 0.1515100 -0.1280742 0.07432917 0.03150000 0.05933333 0.02783333 9.581435e-01 5.292749e-13   FALSE
ENST00000636159 ENSG00000171914 HEK293_OSMI2_6hA HEK293_TMG_6hB TLN2 protein_coding protein_coding 3.272277 5.77275 2.212308 0.4947299 0.1742071 -1.379697 0.3276215 0.5775623 0.0677277 0.28934592 0.0677277 -2.9182411 0.09665000 0.10730000 0.03416667 -0.07313333 7.951577e-01 5.292749e-13 FALSE TRUE
MSTRG.10975.1 ENSG00000171914 HEK293_OSMI2_6hA HEK293_TMG_6hB TLN2 protein_coding   3.272277 5.77275 2.212308 0.4947299 0.1742071 -1.379697 0.6448529 1.6560123 0.0000000 0.64860412 0.0000000 -7.3802552 0.20693333 0.29536667 0.00000000 -0.29536667 4.161947e-03 5.292749e-13 FALSE TRUE
MSTRG.10975.10 ENSG00000171914 HEK293_OSMI2_6hA HEK293_TMG_6hB TLN2 protein_coding   3.272277 5.77275 2.212308 0.4947299 0.1742071 -1.379697 0.2308279 0.1419683 1.0716717 0.14196834 0.3104448 2.8314200 0.09862500 0.02246667 0.50596667 0.48350000 3.932475e-02 5.292749e-13 FALSE TRUE
MSTRG.10975.4 ENSG00000171914 HEK293_OSMI2_6hA HEK293_TMG_6hB TLN2 protein_coding   3.272277 5.77275 2.212308 0.4947299 0.1742071 -1.379697 0.1822455 0.2489376 0.0393726 0.12708964 0.0393726 -2.3908217 0.06763333 0.03970000 0.01540000 -0.02430000 8.579772e-01 5.292749e-13 FALSE TRUE
MSTRG.10975.6 ENSG00000171914 HEK293_OSMI2_6hA HEK293_TMG_6hB TLN2 protein_coding   3.272277 5.77275 2.212308 0.4947299 0.1742071 -1.379697 0.0786200 0.0000000 0.4185982 0.00000000 0.4185982 5.4215539 0.03265833 0.00000000 0.19930000 0.19930000 7.964822e-01 5.292749e-13 FALSE TRUE
MSTRG.10975.7 ENSG00000171914 HEK293_OSMI2_6hA HEK293_TMG_6hB TLN2 protein_coding   3.272277 5.77275 2.212308 0.4947299 0.1742071 -1.379697 0.4675537 0.7486798 0.3780294 0.74867982 0.3780294 -0.9673251 0.13232500 0.12043333 0.14800000 0.02756667 9.573125e-01 5.292749e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171914 E001 0.2027342 0.0353328461 1.000000e+00   15 62390513 62390525 13 + 0.000 0.075 8.267
ENSG00000171914 E002 0.7677130 0.0180045921 1.884888e-01   15 62390526 62390549 24 + 0.000 0.287 13.178
ENSG00000171914 E003 1.6184385 0.0119822750 3.263510e-02 1.350590e-01 15 62390550 62390559 10 + 0.000 0.459 14.143
ENSG00000171914 E004 5.0575724 0.0056178126 5.807829e-03 3.878502e-02 15 62390560 62390685 126 + 0.324 0.821 2.342
ENSG00000171914 E005 0.7844689 0.0203494112 8.030383e-01   15 62453592 62453709 118 + 0.192 0.243 0.433
ENSG00000171914 E006 0.4702677 0.0217681645 1.319566e-01   15 62453710 62453741 32 + 0.324 0.075 -2.567
ENSG00000171914 E007 0.0000000       15 62476326 62476414 89 +      
ENSG00000171914 E008 0.1308682 0.0308802338 1.000000e+00   15 62556550 62556576 27 + 0.000 0.075 10.846
ENSG00000171914 E009 0.0000000       15 62559267 62559357 91 +      
ENSG00000171914 E010 0.0000000       15 62561365 62561482 118 +      
ENSG00000171914 E011 0.6787990 0.0426430498 2.081005e-03   15 62579713 62579740 28 + 0.509 0.000 -15.329
ENSG00000171914 E012 9.8365140 0.1075270489 4.712915e-01 6.810943e-01 15 62589687 62589762 76 + 1.071 0.930 -0.520
ENSG00000171914 E013 6.2236031 0.0320323232 1.886258e-02 9.198201e-02 15 62618351 62618475 125 + 1.020 0.680 -1.323
ENSG00000171914 E014 18.8011457 0.0256605363 2.552852e-02 1.138270e-01 15 62647275 62647446 172 + 1.398 1.156 -0.850
ENSG00000171914 E015 0.1723744 0.0344564910 1.000000e+00   15 62649999 62650083 85 + 0.000 0.075 10.827
ENSG00000171914 E016 15.2855913 0.0023049334 5.499749e-04 6.131319e-03 15 62650084 62650181 98 + 1.355 1.047 -1.093
ENSG00000171914 E017 18.4222930 0.0018933113 1.376867e-02 7.342097e-02 15 62652005 62652134 130 + 1.375 1.173 -0.712
ENSG00000171914 E018 22.2275725 0.0018728622 5.227849e-07 1.609808e-05 15 62653162 62653314 153 + 1.555 1.183 -1.293
ENSG00000171914 E019 19.6375173 0.0043482120 1.043662e-03 1.024396e-02 15 62655944 62656086 143 + 1.441 1.172 -0.942
ENSG00000171914 E020 20.4278651 0.0025961105 1.513940e-02 7.861190e-02 15 62657771 62657898 128 + 1.405 1.210 -0.683
ENSG00000171914 E021 0.0000000       15 62657899 62658174 276 +      
ENSG00000171914 E022 17.5635894 0.0020976085 1.419259e-01 3.503371e-01 15 62673827 62673890 64 + 1.298 1.173 -0.441
ENSG00000171914 E023 19.5264920 0.0142951542 8.874676e-02 2.614901e-01 15 62675217 62675321 105 + 1.365 1.202 -0.571
ENSG00000171914 E024 21.5340566 0.0019067304 1.933955e-02 9.364450e-02 15 62686641 62686796 156 + 1.423 1.243 -0.629
ENSG00000171914 E025 17.8279546 0.0022738766 2.465500e-03 2.010944e-02 15 62692840 62692941 102 + 1.395 1.144 -0.883
ENSG00000171914 E026 15.5866392 0.0023129999 1.081548e-01 2.959626e-01 15 62694316 62694392 77 + 1.260 1.115 -0.516
ENSG00000171914 E027 23.9395896 0.0266366992 2.150972e-01 4.476911e-01 15 62697688 62697868 181 + 1.431 1.301 -0.451
ENSG00000171914 E028 24.2543483 0.0046285724 1.068926e-01 2.938350e-01 15 62698754 62698867 114 + 1.432 1.305 -0.441
ENSG00000171914 E029 25.0233265 0.0020574789 7.635270e-04 7.974443e-03 15 62701106 62701214 109 + 1.521 1.275 -0.849
ENSG00000171914 E030 36.3410049 0.0011077110 7.951295e-06 1.720363e-04 15 62701992 62702200 209 + 1.692 1.424 -0.918
ENSG00000171914 E031 22.7824153 0.0147210622 3.708587e-03 2.752156e-02 15 62702766 62702864 99 + 1.499 1.237 -0.911
ENSG00000171914 E032 24.4384005 0.0051183371 3.112996e-02 1.307251e-01 15 62707086 62707253 168 + 1.467 1.299 -0.581
ENSG00000171914 E033 28.3376567 0.0013169240 1.992725e-01 4.288212e-01 15 62708502 62708796 295 + 1.467 1.379 -0.304
ENSG00000171914 E034 16.8575851 0.0141114995 6.449741e-01 8.001771e-01 15 62711911 62712077 167 + 1.139 1.197 0.205
ENSG00000171914 E035 14.4283585 0.0028620403 5.184930e-01 7.140473e-01 15 62716331 62716459 129 + 1.172 1.114 -0.209
ENSG00000171914 E036 14.9050883 0.0115796035 2.691479e-01 5.089072e-01 15 62717576 62717689 114 + 1.220 1.108 -0.400
ENSG00000171914 E037 17.4739683 0.0734475275 3.413664e-01 5.793098e-01 15 62719767 62719880 114 + 1.305 1.160 -0.510
ENSG00000171914 E038 17.4511600 0.0314603004 9.362924e-01 9.703648e-01 15 62722353 62722487 135 + 1.207 1.198 -0.030
ENSG00000171914 E039 22.5200942 0.0049863743 9.214589e-01 9.629902e-01 15 62724976 62725104 129 + 1.298 1.312 0.048
ENSG00000171914 E040 8.9639780 0.0034675721 7.607753e-01 8.730480e-01 15 62727087 62727089 3 + 0.914 0.957 0.160
ENSG00000171914 E041 17.0834897 0.0022460333 3.145984e-01 5.548049e-01 15 62727090 62727189 100 + 1.121 1.224 0.368
ENSG00000171914 E042 0.0000000       15 62733902 62734091 190 +      
ENSG00000171914 E043 31.1484444 0.0012333359 2.693985e-01 5.091997e-01 15 62736878 62737086 209 + 1.376 1.462 0.298
ENSG00000171914 E044 26.6250992 0.0014239710 3.925950e-01 6.224888e-01 15 62738214 62738333 120 + 1.424 1.364 -0.205
ENSG00000171914 E045 36.0801870 0.0013374300 8.080923e-02 2.464401e-01 15 62739348 62739545 198 + 1.588 1.481 -0.367
ENSG00000171914 E046 0.0000000       15 62740445 62740629 185 +      
ENSG00000171914 E047 31.1843842 0.0014781532 9.415801e-02 2.714758e-01 15 62740630 62740769 140 + 1.528 1.417 -0.379
ENSG00000171914 E048 26.9736479 0.0015857990 7.360536e-03 4.636455e-02 15 62748351 62748444 94 + 1.513 1.324 -0.653
ENSG00000171914 E049 33.0996573 0.0013038468 3.582216e-02 1.437653e-01 15 62750402 62750491 90 + 1.562 1.427 -0.464
ENSG00000171914 E050 31.6422886 0.0024745419 1.604053e-01 3.773946e-01 15 62752305 62752427 123 + 1.514 1.419 -0.327
ENSG00000171914 E051 30.5131291 0.0012146211 6.044184e-01 7.731799e-01 15 62753773 62753916 144 + 1.459 1.427 -0.110
ENSG00000171914 E052 2.6134143 0.0127184054 5.949468e-01 7.670137e-01 15 62753917 62755531 1615 + 0.576 0.487 -0.422
ENSG00000171914 E053 34.4127600 0.0011142015 4.696497e-01 6.797924e-01 15 62755532 62755693 162 + 1.521 1.478 -0.147
ENSG00000171914 E054 0.1723744 0.0344564910 1.000000e+00   15 62758590 62758659 70 + 0.000 0.075 10.827
ENSG00000171914 E055 33.4873600 0.0013323852 9.505262e-01 9.772463e-01 15 62761681 62761821 141 + 1.475 1.476 0.002
ENSG00000171914 E056 39.2915341 0.0016019130 6.294055e-01 7.901031e-01 15 62762272 62762453 182 + 1.514 1.551 0.126
ENSG00000171914 E057 0.0000000       15 62763226 62763562 337 +      
ENSG00000171914 E058 34.4708575 0.0026186064 5.101712e-01 7.081111e-01 15 62763563 62763695 133 + 1.450 1.504 0.184
ENSG00000171914 E059 30.9951298 0.0012552218 4.285810e-01 6.499808e-01 15 62766321 62766422 102 + 1.395 1.459 0.218
ENSG00000171914 E060 42.4920625 0.0021918625 1.745601e-02 8.713792e-02 15 62770964 62771134 171 + 1.450 1.617 0.572
ENSG00000171914 E061 43.7328129 0.0009169050 8.718700e-01 9.369388e-01 15 62776764 62776910 147 + 1.594 1.590 -0.015
ENSG00000171914 E062 40.2115579 0.0011290245 9.629812e-03 5.652439e-02 15 62781140 62781241 102 + 1.657 1.505 -0.518
ENSG00000171914 E063 37.5554879 0.0011720223 1.595566e-01 3.761192e-01 15 62783771 62783890 120 + 1.582 1.497 -0.289
ENSG00000171914 E064 1.5409157 0.0144074892 5.852921e-01 7.605014e-01 15 62783891 62784838 948 + 0.426 0.328 -0.562
ENSG00000171914 E065 40.6455830 0.0011273548 4.835006e-01 6.894398e-01 15 62792641 62792787 147 + 1.521 1.571 0.171
ENSG00000171914 E066 46.6340732 0.0016619025 1.652982e-01 3.843533e-01 15 62796127 62796293 167 + 1.549 1.639 0.310
ENSG00000171914 E067 54.6401626 0.0007210999 1.367180e-01 3.424816e-01 15 62797219 62797402 184 + 1.618 1.707 0.301
ENSG00000171914 E068 42.3397589 0.0008837921 1.389309e-01 3.458855e-01 15 62800368 62800493 126 + 1.498 1.598 0.341
ENSG00000171914 E069 41.0011110 0.0010521461 4.131613e-02 1.581615e-01 15 62800653 62800769 117 + 1.450 1.590 0.480
ENSG00000171914 E070 54.2721765 0.0008418616 6.118029e-01 7.780781e-01 15 62805600 62805785 186 + 1.697 1.675 -0.076
ENSG00000171914 E071 41.4943214 0.0011157718 6.775622e-01 8.211919e-01 15 62809925 62810032 108 + 1.582 1.562 -0.069
ENSG00000171914 E072 41.8151009 0.0061011752 9.581112e-01 9.809744e-01 15 62819516 62819621 106 + 1.562 1.574 0.039
ENSG00000171914 E073 43.1179578 0.0205916178 6.185017e-02 2.069914e-01 15 62820486 62820610 125 + 1.439 1.628 0.646
ENSG00000171914 E074 48.0294000 0.3476224046 1.689260e-01 3.891373e-01 15 62833504 62833629 126 + 1.386 1.687 1.030
ENSG00000171914 E075 0.1723744 0.0344564910 1.000000e+00   15 62835645 62835736 92 + 0.000 0.075 10.827
ENSG00000171914 E076 29.0796059 0.0105203410 2.804933e-03 2.221848e-02 15 62835737 62835799 63 + 1.187 1.480 1.020
ENSG00000171914 E077 56.6160366 0.0009685065 4.173334e-03 3.012787e-02 15 62835891 62836073 183 + 1.562 1.733 0.582
ENSG00000171914 E078 0.3447487 0.4897536988 8.647667e-01   15 62836074 62836118 45 + 0.000 0.141 10.940
ENSG00000171914 E079 54.3526854 0.0015904259 1.151104e-01 3.076322e-01 15 62838856 62838981 126 + 1.600 1.698 0.331
ENSG00000171914 E080 365.4556191 0.0003175313 1.656692e-23 7.232506e-21 15 62840482 62844631 4150 + 2.315 2.547 0.774