ENSG00000171763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305560 ENSG00000171763 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA5L1 protein_coding protein_coding 9.291134 5.511078 13.70577 1.02467 0.4726967 1.312813 4.3220736 3.35439067 4.3079892 0.65478807 0.48541132 0.3600144 0.48482917 0.608366667 0.31256667 -0.29580000 7.361457e-05 7.361457e-05 FALSE TRUE
ENST00000531624 ENSG00000171763 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA5L1 protein_coding protein_coding 9.291134 5.511078 13.70577 1.02467 0.4726967 1.312813 0.4800370 0.00000000 1.2000740 0.00000000 0.60496284 6.9189515 0.05221667 0.000000000 0.08900000 0.08900000 4.260701e-01 7.361457e-05 FALSE TRUE
ENST00000531970 ENSG00000171763 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA5L1 protein_coding nonsense_mediated_decay 9.291134 5.511078 13.70577 1.02467 0.4726967 1.312813 1.0428840 0.53251180 2.0728218 0.19924546 0.03650897 1.9408130 0.10990417 0.088400000 0.15173333 0.06333333 4.510487e-01 7.361457e-05 TRUE TRUE
ENST00000533199 ENSG00000171763 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA5L1 protein_coding retained_intron 9.291134 5.511078 13.70577 1.02467 0.4726967 1.312813 0.4900538 0.17971056 0.8994554 0.05360743 0.05587405 2.2612029 0.05262083 0.040066667 0.06590000 0.02583333 6.352492e-01 7.361457e-05   FALSE
MSTRG.10721.5 ENSG00000171763 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA5L1 protein_coding   9.291134 5.511078 13.70577 1.02467 0.4726967 1.312813 0.5581124 0.02758239 1.1185167 0.02758239 0.31433102 4.9082270 0.06061250 0.007833333 0.08256667 0.07473333 1.259864e-01 7.361457e-05 FALSE TRUE
MSTRG.10721.6 ENSG00000171763 HEK293_OSMI2_6hA HEK293_TMG_6hB SPATA5L1 protein_coding   9.291134 5.511078 13.70577 1.02467 0.4726967 1.312813 1.7001167 1.23024389 3.2747524 0.38590616 0.50869057 1.4051608 0.17065833 0.217933333 0.23803333 0.02010000 9.506576e-01 7.361457e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171763 E001 4.135204 0.0802313810 4.864021e-01 6.915246e-01 15 45402336 45402369 34 + 0.646 0.759 0.469
ENSG00000171763 E002 4.135204 0.0802313810 4.864021e-01 6.915246e-01 15 45402370 45402374 5 + 0.646 0.759 0.469
ENSG00000171763 E003 87.362092 0.0005068842 3.932841e-09 2.017176e-07 15 45402375 45403249 875 + 1.845 2.057 0.714
ENSG00000171763 E004 49.568836 0.0008641587 7.016749e-02 2.251144e-01 15 45403250 45403518 269 + 1.662 1.750 0.299
ENSG00000171763 E005 57.052661 0.0024076547 6.494255e-01 8.030771e-01 15 45405320 45405458 139 + 1.749 1.771 0.075
ENSG00000171763 E006 40.798550 0.0013198045 4.509945e-01 6.663327e-01 15 45405459 45405505 47 + 1.631 1.587 -0.149
ENSG00000171763 E007 1.623826 0.2042095443 7.593852e-01 8.721718e-01 15 45407029 45407061 33 + 0.431 0.363 -0.378
ENSG00000171763 E008 7.470150 0.0176830381 1.144819e-01 3.065928e-01 15 45407062 45407223 162 + 0.979 0.757 -0.854
ENSG00000171763 E009 29.811371 0.0012089563 1.390836e-01 3.461203e-01 15 45410372 45410372 1 + 1.513 1.412 -0.344
ENSG00000171763 E010 85.150292 0.0078630815 9.632345e-01 9.835625e-01 15 45410373 45410530 158 + 1.928 1.922 -0.018
ENSG00000171763 E011 89.220458 0.0006462073 4.679947e-01 6.787332e-01 15 45414571 45414780 210 + 1.937 1.963 0.087
ENSG00000171763 E012 97.535792 0.0089697521 3.810483e-01 6.130550e-01 15 45415587 45415779 193 + 1.995 1.946 -0.163
ENSG00000171763 E013 8.752867 0.0034428481 1.016664e-01 2.847743e-01 15 45415780 45415809 30 + 1.039 0.845 -0.729
ENSG00000171763 E014 1.407733 0.0649016927 4.210870e-01 6.444804e-01 15 45415810 45415905 96 + 0.431 0.268 -0.988
ENSG00000171763 E015 6.066808 0.0060238771 2.170272e-01 4.499193e-01 15 45416854 45417268 415 + 0.892 0.723 -0.666
ENSG00000171763 E016 55.320752 0.0010330714 7.326392e-02 2.313363e-01 15 45417269 45417310 42 + 1.766 1.675 -0.308
ENSG00000171763 E017 76.702996 0.0009499630 5.818852e-01 7.583379e-01 15 45417311 45417399 89 + 1.884 1.858 -0.085
ENSG00000171763 E018 1.138656 0.0965762188 2.528131e-01   15 45417695 45417794 100 + 0.391 0.156 -1.757
ENSG00000171763 E019 78.125880 0.0011982767 2.723001e-02 1.189771e-01 15 45418557 45418682 126 + 1.915 1.818 -0.328
ENSG00000171763 E020 84.676184 0.0005259936 6.603453e-01 8.101685e-01 15 45421043 45421415 373 + 1.926 1.907 -0.063