ENSG00000171444

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302475 ENSG00000171444 HEK293_OSMI2_6hA HEK293_TMG_6hB MCC protein_coding protein_coding 2.047382 2.181658 1.826491 0.3422382 0.1543488 -0.255071 0.91897753 1.00541259 0.8829866 0.13796212 0.05279988 -0.1853556 0.45569167 0.46403333 0.4899667 0.02593333 0.95832014 0.02213382 FALSE TRUE
ENST00000408903 ENSG00000171444 HEK293_OSMI2_6hA HEK293_TMG_6hB MCC protein_coding protein_coding 2.047382 2.181658 1.826491 0.3422382 0.1543488 -0.255071 0.29177178 0.27544640 0.3821794 0.11746889 0.06108134 0.4582940 0.14657083 0.11400000 0.2172667 0.10326667 0.69736701 0.02213382 FALSE TRUE
ENST00000506605 ENSG00000171444 HEK293_OSMI2_6hA HEK293_TMG_6hB MCC protein_coding processed_transcript 2.047382 2.181658 1.826491 0.3422382 0.1543488 -0.255071 0.10625104 0.08432513 0.2062693 0.04651192 0.11132399 1.1971148 0.05221667 0.03486667 0.1060667 0.07120000 0.82812531 0.02213382 FALSE FALSE
ENST00000511242 ENSG00000171444 HEK293_OSMI2_6hA HEK293_TMG_6hB MCC protein_coding processed_transcript 2.047382 2.181658 1.826491 0.3422382 0.1543488 -0.255071 0.65391531 0.81647370 0.1031934 0.11817141 0.06856506 -2.8681791 0.30777083 0.38713333 0.0514000 -0.33573333 0.02213382 0.02213382 FALSE FALSE
ENST00000515367 ENSG00000171444 HEK293_OSMI2_6hA HEK293_TMG_6hB MCC protein_coding protein_coding 2.047382 2.181658 1.826491 0.3422382 0.1543488 -0.255071 0.04564181 0.00000000 0.2518619 0.00000000 0.12598817 4.7107343 0.02407500 0.00000000 0.1353000 0.13530000 0.22458316 0.02213382 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171444 E001 0.0000000       5 113022099 113022105 7 -      
ENSG00000171444 E002 140.2785857 0.015403770 1.841198e-01 4.093020e-01 5 113022106 113026131 4026 - 2.102 2.185 0.278
ENSG00000171444 E003 68.6130852 0.000766431 3.303322e-01 5.692802e-01 5 113026132 113027482 1351 - 1.854 1.834 -0.069
ENSG00000171444 E004 15.0696359 0.007549936 9.485379e-01 9.765161e-01 5 113028934 113029056 123 - 1.190 1.209 0.067
ENSG00000171444 E005 8.2069209 0.069054740 7.133029e-01 8.438892e-01 5 113043530 113043630 101 - 0.991 0.928 -0.232
ENSG00000171444 E006 0.0000000       5 113048563 113048727 165 -      
ENSG00000171444 E007 0.2027342 0.033693842 5.395193e-01   5 113048876 113049092 217 - 0.000 0.117 10.058
ENSG00000171444 E008 10.8728675 0.016140782 5.408298e-01 7.296146e-01 5 113049093 113049299 207 - 1.033 1.113 0.292
ENSG00000171444 E009 10.3434008 0.005019616 6.549700e-01 8.067148e-01 5 113053725 113053959 235 - 1.019 1.083 0.232
ENSG00000171444 E010 7.9452385 0.007313068 5.507354e-01 7.368608e-01 5 113063984 113064167 184 - 0.975 0.924 -0.192
ENSG00000171444 E011 7.7805802 0.005548897 1.182495e-01 3.129812e-01 5 113068080 113068183 104 - 1.019 0.855 -0.617
ENSG00000171444 E012 11.6340887 0.003865563 9.701811e-02 2.765295e-01 5 113071094 113071234 141 - 1.171 1.024 -0.529
ENSG00000171444 E013 13.0547662 0.038511712 8.387675e-01 9.187318e-01 5 113082860 113083008 149 - 1.158 1.138 -0.072
ENSG00000171444 E014 10.3522119 0.004199570 8.068471e-01 9.002423e-01 5 113084101 113084190 90 - 1.032 1.072 0.145
ENSG00000171444 E015 7.7485160 0.028211444 6.944721e-01 8.319976e-01 5 113085164 113085310 147 - 0.908 0.970 0.233
ENSG00000171444 E016 0.0000000       5 113101500 113101542 43 -      
ENSG00000171444 E017 0.0000000       5 113101543 113101733 191 -      
ENSG00000171444 E018 0.3559677 0.406722657 2.649418e-01   5 113101734 113101738 5 - 0.228 0.000 -10.256
ENSG00000171444 E019 12.4432344 0.053976781 4.921334e-01 6.954367e-01 5 113101739 113101945 207 - 1.174 1.081 -0.334
ENSG00000171444 E020 11.8149207 0.033726963 1.527757e-01 3.663386e-01 5 113104192 113104355 164 - 1.191 1.039 -0.546
ENSG00000171444 E021 0.2027342 0.033693842 5.395193e-01   5 113104356 113104625 270 - 0.000 0.117 10.058
ENSG00000171444 E022 11.6089986 0.070740233 1.776006e-01 4.005719e-01 5 113122684 113122826 143 - 1.196 1.020 -0.632
ENSG00000171444 E023 0.0000000       5 113122827 113122830 4 -      
ENSG00000171444 E024 9.9927846 0.004020388 1.101735e-01 2.992784e-01 5 113143218 113143360 143 - 1.118 0.970 -0.543
ENSG00000171444 E025 7.8208554 0.004665174 2.009881e-01 4.309647e-01 5 113151309 113151422 114 - 1.019 0.891 -0.477
ENSG00000171444 E026 0.7968555 0.017198055 5.580996e-01   5 113203237 113203317 81 - 0.303 0.209 -0.713
ENSG00000171444 E027 0.0000000       5 113204513 113204576 64 -      
ENSG00000171444 E028 0.0000000       5 113234437 113234677 241 -      
ENSG00000171444 E029 6.1742476 0.022829019 6.715724e-01 8.172802e-01 5 113294329 113294949 621 - 0.889 0.851 -0.144
ENSG00000171444 E030 3.1768884 0.007761179 2.415991e-01 4.783782e-01 5 113340519 113340730 212 - 0.703 0.540 -0.716
ENSG00000171444 E031 3.0174980 0.009488682 6.050745e-01 7.735813e-01 5 113384968 113385212 245 - 0.641 0.577 -0.284
ENSG00000171444 E032 5.9806642 0.034871263 2.029744e-04 2.708393e-03 5 113448123 113448287 165 - 0.428 1.028 2.522
ENSG00000171444 E033 7.5239127 0.004261293 1.532420e-06 4.123596e-05 5 113488245 113488823 579 - 0.480 1.125 2.609