ENSG00000171320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305188 ENSG00000171320 HEK293_OSMI2_6hA HEK293_TMG_6hB ESCO2 protein_coding protein_coding 8.15498 0.9952034 15.94142 0.07582916 1.211482 3.988126 5.120526 0.8525851 10.208622 0.09771624 0.1187730 3.566390 0.73320833 0.8595333 0.6464667 -0.2130667 0.3258369506 0.0003875356 FALSE TRUE
ENST00000523910 ENSG00000171320 HEK293_OSMI2_6hA HEK293_TMG_6hB ESCO2 protein_coding processed_transcript 8.15498 0.9952034 15.94142 0.07582916 1.211482 3.988126 1.479625 0.0000000 2.840931 0.00000000 0.6577787 8.155289 0.09528333 0.0000000 0.1742667 0.1742667 0.0003875356 0.0003875356 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171320 E001 0.0000000       8 27771949 27772068 120 +      
ENSG00000171320 E002 0.0000000       8 27774501 27774534 34 +      
ENSG00000171320 E003 0.1779838 0.0353630076 0.48738829   8 27774535 27774536 2 + 0.038 0.000 -6.630
ENSG00000171320 E004 1.5289975 0.0859276159 0.76241993 0.87403764 8 27774537 27774553 17 + 0.259 0.330 0.477
ENSG00000171320 E005 14.6516971 0.0207093280 0.72823238 0.85320084 8 27774554 27774607 54 + 0.949 0.892 -0.215
ENSG00000171320 E006 0.0000000       8 27774669 27774827 159 +      
ENSG00000171320 E007 0.1426347 0.0327367570 0.48659532   8 27775497 27775498 2 + 0.038 0.000 -8.435
ENSG00000171320 E008 25.3757911 0.0235109401 0.35163685 0.58874705 8 27775499 27775567 69 + 1.154 1.279 0.441
ENSG00000171320 E009 43.3921390 0.0011051363 0.74899659 0.86614494 8 27776362 27776509 148 + 1.379 1.414 0.120
ENSG00000171320 E010 68.5853301 0.0094904520 0.71597450 0.84559491 8 27776510 27776678 169 + 1.574 1.608 0.117
ENSG00000171320 E011 121.5444629 0.0003451923 0.19492021 0.42326499 8 27776679 27777169 491 + 1.823 1.752 -0.237
ENSG00000171320 E012 7.1475632 0.0336604654 0.01173095 0.06536038 8 27777170 27780095 2926 + 0.626 1.051 1.668
ENSG00000171320 E013 26.7759582 0.0014195661 0.48461457 0.69024583 8 27780174 27780198 25 + 1.172 1.256 0.295
ENSG00000171320 E014 34.6864348 0.0013895481 0.68096854 0.82327602 8 27780199 27780267 69 + 1.283 1.330 0.166
ENSG00000171320 E015 32.9120815 0.0037817523 0.89281586 0.94804394 8 27784000 27784057 58 + 1.262 1.282 0.068
ENSG00000171320 E016 36.0386391 0.0010067733 0.42706767 0.64876679 8 27787885 27787927 43 + 1.309 1.227 -0.287
ENSG00000171320 E017 46.5394300 0.0009367669 0.35991459 0.59569396 8 27787928 27788002 75 + 1.415 1.331 -0.291
ENSG00000171320 E018 56.4105124 0.0007077312 0.31017607 0.55065421 8 27788847 27788978 132 + 1.498 1.414 -0.289
ENSG00000171320 E019 42.8688474 0.0011926166 0.56608898 0.74739743 8 27791963 27792052 90 + 1.382 1.331 -0.180
ENSG00000171320 E020 49.6478857 0.0026760446 0.58260456 0.75876877 8 27792668 27792811 144 + 1.441 1.395 -0.160
ENSG00000171320 E021 54.8047081 0.0027786501 0.83528801 0.91668979 8 27799541 27799716 176 + 1.477 1.500 0.079
ENSG00000171320 E022 29.8186193 0.0114609569 0.57697253 0.75509938 8 27803306 27803373 68 + 1.230 1.163 -0.236
ENSG00000171320 E023 24.3680359 0.0025492698 0.41931320 0.64314142 8 27803374 27803392 19 + 1.151 1.049 -0.366
ENSG00000171320 E024 205.8994927 0.0002774446 0.33288140 0.57152741 8 27803393 27805316 1924 + 2.040 2.083 0.145
ENSG00000171320 E025 1.3354204 0.3186531703 0.59820998   8 27808194 27808338 145 + 0.219 0.331 0.803
ENSG00000171320 E026 0.9497130 0.4973209840 1.00000000   8 27811305 27811339 35 + 0.190 0.000 -10.028
ENSG00000171320 E027 4.1451606 0.0107400360 0.98712958 0.99540001 8 27811340 27811699 360 + 0.506 0.514 0.041
ENSG00000171320 E028 6.2712187 0.3998934441 0.55920505 0.74272493 8 27811977 27812640 664 + 0.591 0.965 1.501