ENSG00000171316

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423902 ENSG00000171316 HEK293_OSMI2_6hA HEK293_TMG_6hB CHD7 protein_coding protein_coding 10.7977 12.85946 12.68318 3.612716 1.264888 -0.01989776 1.8482443 0.4469722 2.808999 0.2323330 0.3273157 2.6250045 0.1634958 0.0488000 0.22416667 0.17536667 3.978347e-01 1.363543e-10 FALSE TRUE
ENST00000527921 ENSG00000171316 HEK293_OSMI2_6hA HEK293_TMG_6hB CHD7 protein_coding processed_transcript 10.7977 12.85946 12.68318 3.612716 1.264888 -0.01989776 1.7958007 2.7693993 1.517091 0.9045349 0.7625437 -0.8639873 0.1575292 0.2059000 0.10903333 -0.09686667 7.656744e-01 1.363543e-10 FALSE FALSE
ENST00000529472 ENSG00000171316 HEK293_OSMI2_6hA HEK293_TMG_6hB CHD7 protein_coding processed_transcript 10.7977 12.85946 12.68318 3.612716 1.264888 -0.01989776 0.3408951 0.0000000 1.259361 0.0000000 0.6600410 6.9879584 0.0250250 0.0000000 0.09433333 0.09433333 3.940182e-05 1.363543e-10 FALSE FALSE
ENST00000695850 ENSG00000171316 HEK293_OSMI2_6hA HEK293_TMG_6hB CHD7 protein_coding processed_transcript 10.7977 12.85946 12.68318 3.612716 1.264888 -0.01989776 1.7042704 3.5643964 0.000000 1.4644292 0.0000000 -8.4815558 0.1657708 0.2444333 0.00000000 -0.24443333 1.363543e-10 1.363543e-10 FALSE TRUE
MSTRG.31555.6 ENSG00000171316 HEK293_OSMI2_6hA HEK293_TMG_6hB CHD7 protein_coding   10.7977 12.85946 12.68318 3.612716 1.264888 -0.01989776 2.2254109 2.4207804 3.609227 0.5265075 0.3490289 0.5742619 0.2092542 0.2065667 0.28956667 0.08300000 6.375949e-01 1.363543e-10 FALSE TRUE
MSTRG.31555.7 ENSG00000171316 HEK293_OSMI2_6hA HEK293_TMG_6hB CHD7 protein_coding   10.7977 12.85946 12.68318 3.612716 1.264888 -0.01989776 1.7206897 3.0047305 2.228657 0.9915279 0.1960979 -0.4293958 0.1642000 0.2246000 0.18153333 -0.04306667 7.876106e-01 1.363543e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171316 E001 0.0000000       8 60678740 60678743 4 +      
ENSG00000171316 E002 0.2922838 0.0253390909 1.000000e+00   8 60678744 60678799 56 + 0.115 0.128 0.190
ENSG00000171316 E003 2.3660375 0.0518136920 7.052511e-01 8.388756e-01 8 60678800 60678822 23 + 0.493 0.574 0.383
ENSG00000171316 E004 7.3751841 0.1470460310 3.604524e-01 5.960613e-01 8 60678823 60678918 96 + 0.840 1.008 0.634
ENSG00000171316 E005 16.9990053 0.4980104563 6.225521e-01 7.855511e-01 8 60678919 60679082 164 + 1.246 1.267 0.076
ENSG00000171316 E006 1.7421199 0.1928369256 4.284232e-01 6.498226e-01 8 60679564 60679791 228 + 0.346 0.529 0.970
ENSG00000171316 E007 26.7857244 0.0135210940 8.137752e-02 2.475686e-01 8 60741259 60741364 106 + 1.506 1.377 -0.442
ENSG00000171316 E008 25.6421288 0.0108088499 2.279605e-03 1.891758e-02 8 60741365 60741432 68 + 1.524 1.295 -0.790
ENSG00000171316 E009 73.4203202 0.0070470351 1.138551e-05 2.343378e-04 8 60741433 60741854 422 + 1.967 1.733 -0.790
ENSG00000171316 E010 15.2763435 0.0021705020 1.595556e-02 8.164216e-02 8 60741855 60741885 31 + 1.288 1.105 -0.651
ENSG00000171316 E011 125.4303281 0.0024401680 1.737259e-09 9.698437e-08 8 60741886 60742819 934 + 2.192 1.976 -0.723
ENSG00000171316 E012 60.9179743 0.0046706487 1.739117e-03 1.529015e-02 8 60742820 60743031 212 + 1.858 1.705 -0.518
ENSG00000171316 E013 39.7676886 0.0012317939 2.893938e-03 2.276424e-02 8 60743032 60743097 66 + 1.674 1.533 -0.480
ENSG00000171316 E014 37.4748175 0.0017517738 2.802395e-03 2.219955e-02 8 60781000 60781050 51 + 1.654 1.505 -0.508
ENSG00000171316 E015 73.8770256 0.0024506047 1.936535e-05 3.720650e-04 8 60781051 60781430 380 + 1.952 1.780 -0.577
ENSG00000171316 E016 50.6955860 0.0015084278 1.106111e-05 2.290211e-04 8 60794986 60795127 142 + 1.799 1.597 -0.683
ENSG00000171316 E017 58.1416720 0.0043887950 5.481017e-03 3.711779e-02 8 60800388 60800525 138 + 1.829 1.697 -0.447
ENSG00000171316 E018 0.0000000       8 60800526 60800526 1 +      
ENSG00000171316 E019 42.3927202 0.0010894618 6.226207e-02 2.078718e-01 8 60801528 60801593 66 + 1.674 1.601 -0.245
ENSG00000171316 E020 24.5095453 0.0017741676 1.841365e-01 4.093281e-01 8 60808217 60808219 3 + 1.435 1.370 -0.227
ENSG00000171316 E021 39.7999043 0.0015313930 8.165512e-02 2.481331e-01 8 60808220 60808272 53 + 1.645 1.574 -0.239
ENSG00000171316 E022 0.3807181 0.0348011929 1.000000e+00   8 60808273 60809651 1379 + 0.115 0.129 0.195
ENSG00000171316 E023 51.7084368 0.0007555088 7.555822e-02 2.359643e-01 8 60816387 60816501 115 + 1.752 1.695 -0.193
ENSG00000171316 E024 50.9171422 0.0034148940 1.292245e-03 1.210374e-02 8 60820007 60820090 84 + 1.784 1.635 -0.506
ENSG00000171316 E025 59.7989884 0.0006644473 2.746914e-04 3.474521e-03 8 60821790 60821927 138 + 1.848 1.710 -0.465
ENSG00000171316 E026 49.4188661 0.0010328324 3.685244e-03 2.739502e-02 8 60822024 60822145 122 + 1.755 1.637 -0.399
ENSG00000171316 E027 74.5593518 0.0005417688 1.512376e-05 3.003697e-04 8 60822503 60822746 244 + 1.946 1.797 -0.500
ENSG00000171316 E028 72.3126975 0.0008983833 4.444597e-06 1.039801e-04 8 60823840 60824016 177 + 1.937 1.767 -0.571
ENSG00000171316 E029 0.4279040 0.6990849530 3.423973e-01   8 60824017 60825415 1399 + 0.271 0.000 -12.032
ENSG00000171316 E030 64.5871575 0.0044361804 2.530997e-02 1.131621e-01 8 60828663 60828806 144 + 1.858 1.761 -0.327
ENSG00000171316 E031 85.7371434 0.0005737122 5.318518e-02 1.872358e-01 8 60830322 60830577 256 + 1.961 1.917 -0.149
ENSG00000171316 E032 70.6128943 0.0006800893 8.225905e-02 2.492267e-01 8 60836073 60836283 211 + 1.876 1.834 -0.143
ENSG00000171316 E033 73.9147957 0.0005831271 8.687026e-02 2.579977e-01 8 60836817 60837012 196 + 1.894 1.853 -0.137
ENSG00000171316 E034 75.3110315 0.0011412327 7.366274e-04 7.755023e-03 8 60837668 60837835 168 + 1.935 1.818 -0.393
ENSG00000171316 E035 83.9097985 0.0019255103 4.585601e-02 1.696972e-01 8 60838076 60838255 180 + 1.956 1.895 -0.203
ENSG00000171316 E036 70.1430503 0.0006932365 5.544824e-02 1.923517e-01 8 60841644 60841754 111 + 1.880 1.829 -0.172
ENSG00000171316 E037 93.2177548 0.0015517390 2.561405e-01 4.949143e-01 8 60841847 60842052 206 + 1.987 1.970 -0.056
ENSG00000171316 E038 90.8836811 0.0005850278 9.246278e-02 2.683146e-01 8 60844864 60845063 200 + 1.984 1.952 -0.108
ENSG00000171316 E039 76.6615697 0.0005824782 2.986335e-01 5.390868e-01 8 60845250 60845409 160 + 1.900 1.889 -0.038
ENSG00000171316 E040 2.1672474 0.0785259837 8.459819e-01 9.226727e-01 8 60846500 60846567 68 + 0.491 0.532 0.200
ENSG00000171316 E041 52.2191826 0.0104803289 3.183561e-01 5.582434e-01 8 60848515 60848604 90 + 1.744 1.710 -0.116
ENSG00000171316 E042 56.9829532 0.0087516989 4.364967e-01 6.561378e-01 8 60849051 60849154 104 + 1.772 1.752 -0.066
ENSG00000171316 E043 65.7227902 0.0051318903 4.713793e-01 6.811522e-01 8 60850493 60850622 130 + 1.826 1.822 -0.013
ENSG00000171316 E044 0.1723744 0.1110816563 4.463570e-01   8 60850737 60850761 25 + 0.000 0.129 10.970
ENSG00000171316 E045 57.5415607 0.0234979623 6.667625e-01 8.141645e-01 8 60851032 60851104 73 + 1.762 1.778 0.054
ENSG00000171316 E046 53.5406278 0.0042702227 4.457093e-01 6.625568e-01 8 60851262 60851319 58 + 1.704 1.784 0.271
ENSG00000171316 E047 113.6850183 0.0003469250 4.800655e-02 1.750091e-01 8 60852019 60852247 229 + 2.014 2.111 0.325
ENSG00000171316 E048 103.0458438 0.0004058696 2.725314e-01 5.123706e-01 8 60852498 60852706 209 + 1.985 2.054 0.232
ENSG00000171316 E049 250.5774848 0.0002125535 8.658079e-02 2.575434e-01 8 60852829 60853500 672 + 2.369 2.438 0.233
ENSG00000171316 E050 27.8849507 0.0029268676 1.626358e-01 3.806776e-01 8 60854363 60854365 3 + 1.395 1.524 0.442
ENSG00000171316 E051 94.1977377 0.0041122671 1.573116e-02 8.084469e-02 8 60854366 60854523 158 + 1.904 2.051 0.495
ENSG00000171316 E052 0.1614157 0.0352850003 5.414077e-01   8 60855093 60855209 117 + 0.115 0.000 -12.100
ENSG00000171316 E053 0.2852693 0.3678693267 3.343395e-01   8 60855571 60855682 112 + 0.202 0.000 -11.771
ENSG00000171316 E054 119.0252581 0.0028881919 7.574805e-01 8.711273e-01 8 60855975 60856202 228 + 2.063 2.109 0.154
ENSG00000171316 E055 173.5541035 0.0060522104 1.496593e-01 3.617813e-01 8 60856445 60856856 412 + 2.196 2.293 0.324
ENSG00000171316 E056 53.4291868 0.0154641949 3.672231e-01 6.017274e-01 8 60856857 60856888 32 + 1.687 1.795 0.367
ENSG00000171316 E057 40.0270553 0.0260580491 4.149122e-01 6.397585e-01 8 60860904 60860915 12 + 1.553 1.682 0.438
ENSG00000171316 E058 126.4929660 0.0079641347 5.836267e-02 1.991105e-01 8 60860916 60861125 210 + 2.034 2.174 0.466
ENSG00000171316 E059 4.4755138 0.1464991270 9.740723e-01 9.889216e-01 8 60861126 60861943 818 + 0.725 0.723 -0.008
ENSG00000171316 E060 0.5530924 0.0401115891 5.256227e-01   8 60861944 60862195 252 + 0.115 0.229 1.196
ENSG00000171316 E061 48.5493661 0.0162763999 2.516444e-01 4.896649e-01 8 60862196 60862198 3 + 1.628 1.752 0.421
ENSG00000171316 E062 65.4101717 0.0034196320 2.336039e-01 4.693164e-01 8 60862199 60862228 30 + 1.773 1.864 0.306
ENSG00000171316 E063 99.7096176 0.0073264887 9.058112e-02 2.648455e-01 8 60862229 60862336 108 + 1.936 2.063 0.427
ENSG00000171316 E064 1.3580281 0.0600916225 1.446163e-01   8 60862337 60862530 194 + 0.491 0.227 -1.609
ENSG00000171316 E065 1.0845253 0.0782124355 8.775329e-02   8 60862531 60862547 17 + 0.447 0.129 -2.381
ENSG00000171316 E066 43.0519364 0.0016786432 1.850114e-01 4.105389e-01 8 60862548 60862549 2 + 1.595 1.701 0.361
ENSG00000171316 E067 77.9996447 0.0005964647 4.596025e-07 1.437140e-05 8 60862550 60862652 103 + 1.771 2.008 0.801
ENSG00000171316 E068 15.8440825 0.1390197192 5.860547e-01 7.609936e-01 8 60862653 60864935 2283 + 1.168 1.283 0.405
ENSG00000171316 E069 3.0600290 0.0920759933 3.145641e-01 5.547768e-01 8 60864936 60865015 80 + 0.494 0.688 0.872
ENSG00000171316 E070 663.3684392 0.0030001315 9.030755e-18 1.996914e-15 8 60865016 60868028 3013 + 2.681 2.939 0.857