ENSG00000171307

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352634 ENSG00000171307 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC16 protein_coding protein_coding 63.06802 93.05897 33.93271 10.69471 1.299253 -1.455198 17.529698 26.835363 11.785844 3.7945718 0.16911712 -1.186394 0.27324583 0.2868000 0.3480667 0.06126667 4.032731e-01 1.907353e-26 FALSE TRUE
ENST00000370854 ENSG00000171307 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC16 protein_coding protein_coding 63.06802 93.05897 33.93271 10.69471 1.299253 -1.455198 13.988617 22.480728 6.271790 3.2925976 0.30986948 -1.840083 0.22190000 0.2398667 0.1848000 -0.05506667 2.315680e-01 1.907353e-26 FALSE TRUE
ENST00000420089 ENSG00000171307 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC16 protein_coding protein_coding 63.06802 93.05897 33.93271 10.69471 1.299253 -1.455198 2.154261 0.000000 3.839047 0.0000000 0.78875177 8.588358 0.03831667 0.0000000 0.1117667 0.11176667 1.907353e-26 1.907353e-26 FALSE TRUE
MSTRG.4456.6 ENSG00000171307 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC16 protein_coding   63.06802 93.05897 33.93271 10.69471 1.299253 -1.455198 4.883845 10.378402 0.000000 1.9195402 0.00000000 -10.020758 0.06970833 0.1094667 0.0000000 -0.10946667 1.957852e-25 1.907353e-26 FALSE TRUE
MSTRG.4456.7 ENSG00000171307 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC16 protein_coding   63.06802 93.05897 33.93271 10.69471 1.299253 -1.455198 5.668752 9.649687 3.946206 0.6947367 0.09403574 -1.287859 0.08536250 0.1049000 0.1168333 0.01193333 8.512739e-01 1.907353e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171307 E001 0.0000000       10 97446071 97446118 48 +      
ENSG00000171307 E002 0.0000000       10 97446119 97446138 20 +      
ENSG00000171307 E003 0.6783511 0.0193874923 3.581161e-01   10 97446139 97446154 16 + 0.001 0.227 9.094
ENSG00000171307 E004 0.6783511 0.0193874923 3.581161e-01   10 97446155 97446157 3 + 0.000 0.227 11.185
ENSG00000171307 E005 2.6840449 0.0085257331 2.984665e-01 5.389216e-01 10 97446158 97446158 1 + 0.345 0.552 1.078
ENSG00000171307 E006 3.8268665 0.0064777393 8.394289e-02 2.526753e-01 10 97446159 97446159 1 + 0.345 0.678 1.631
ENSG00000171307 E007 5.0590501 0.0055936995 1.820655e-02 8.970915e-02 10 97446160 97446161 2 + 0.345 0.787 2.078
ENSG00000171307 E008 7.8744634 0.0038085354 1.996611e-01 4.292303e-01 10 97446162 97446169 8 + 0.720 0.913 0.758
ENSG00000171307 E009 9.2200193 0.0033337311 7.266868e-02 2.301360e-01 10 97446170 97446174 5 + 0.720 0.981 1.010
ENSG00000171307 E010 9.3508874 0.0033429983 6.392823e-02 2.115243e-01 10 97446175 97446175 1 + 0.720 0.988 1.038
ENSG00000171307 E011 9.3508874 0.0033429983 6.392823e-02 2.115243e-01 10 97446176 97446176 1 + 0.720 0.988 1.038
ENSG00000171307 E012 44.7180588 0.0085687686 1.884015e-01 4.149201e-01 10 97446177 97446190 14 + 1.489 1.607 0.404
ENSG00000171307 E013 58.3034786 0.0059229297 7.564612e-03 4.733401e-02 10 97446191 97446193 3 + 1.529 1.732 0.690
ENSG00000171307 E014 69.7605526 0.0066225772 7.693420e-04 8.022348e-03 10 97446194 97446194 1 + 1.567 1.814 0.839
ENSG00000171307 E015 74.9491857 0.0085381251 4.827902e-04 5.518907e-03 10 97446195 97446195 1 + 1.581 1.847 0.901
ENSG00000171307 E016 76.1398631 0.0099494189 5.298124e-04 5.947536e-03 10 97446196 97446196 1 + 1.581 1.854 0.926
ENSG00000171307 E017 92.4801278 0.0139590336 9.019872e-04 9.110156e-03 10 97446197 97446201 5 + 1.664 1.935 0.915
ENSG00000171307 E018 98.5445942 0.0126446494 1.563219e-04 2.174919e-03 10 97446202 97446203 2 + 1.670 1.966 0.997
ENSG00000171307 E019 123.8173750 0.0091382651 7.835757e-06 1.698047e-04 10 97446204 97446209 6 + 1.762 2.064 1.017
ENSG00000171307 E020 128.2327533 0.0077583255 3.073957e-06 7.588728e-05 10 97446210 97446211 2 + 1.779 2.079 1.009
ENSG00000171307 E021 289.6886677 0.0046496607 1.033780e-04 1.537704e-03 10 97446212 97446353 142 + 2.237 2.414 0.592
ENSG00000171307 E022 10.7478547 0.0909485340 1.572478e-01 3.725644e-01 10 97448190 97448350 161 + 1.158 0.930 -0.833
ENSG00000171307 E023 34.2729287 0.0024878365 5.376682e-01 7.274564e-01 10 97450357 97450380 24 + 1.497 1.458 -0.131
ENSG00000171307 E024 58.4946369 0.0038631179 3.956442e-01 6.249428e-01 10 97450381 97450536 156 + 1.731 1.685 -0.155
ENSG00000171307 E025 34.8333933 0.1013335967 5.289950e-01 7.213092e-01 10 97450828 97451193 366 + 1.521 1.457 -0.222
ENSG00000171307 E026 242.4298388 0.0041398305 6.974220e-02 2.242810e-01 10 97451671 97451735 65 + 2.236 2.322 0.288
ENSG00000171307 E027 161.4368073 0.0005477814 1.528539e-01 3.664047e-01 10 97451736 97451748 13 + 2.084 2.143 0.199
ENSG00000171307 E028 340.2028665 0.0005270729 7.580171e-01 8.713312e-01 10 97451749 97451850 102 + 2.439 2.455 0.052
ENSG00000171307 E029 333.0037501 0.0003557256 2.256155e-01 4.600709e-01 10 97451851 97451918 68 + 2.460 2.439 -0.069
ENSG00000171307 E030 655.7876599 0.0001403660 1.106870e-02 6.265940e-02 10 97452090 97452284 195 + 2.762 2.728 -0.113
ENSG00000171307 E031 537.5719520 0.0001520562 1.895081e-01 4.163369e-01 10 97452415 97452503 89 + 2.661 2.645 -0.054
ENSG00000171307 E032 8.0025320 0.0059019456 8.968665e-02 2.632273e-01 10 97452807 97452809 3 + 1.030 0.823 -0.780
ENSG00000171307 E033 25.8305588 0.0020160837 4.285952e-02 1.621813e-01 10 97452810 97452894 85 + 1.462 1.312 -0.518
ENSG00000171307 E034 355.7464036 0.0005743749 2.755857e-01 5.156601e-01 10 97452895 97452923 29 + 2.485 2.465 -0.068
ENSG00000171307 E035 296.0109369 0.0013089593 2.598813e-01 4.989016e-01 10 97453530 97453553 24 + 2.412 2.384 -0.092
ENSG00000171307 E036 393.1187724 0.0004082549 5.390548e-03 3.665422e-02 10 97453554 97453617 64 + 2.556 2.501 -0.184
ENSG00000171307 E037 359.0457182 0.0001574742 5.232914e-02 1.850854e-01 10 97453618 97453663 46 + 2.502 2.467 -0.116
ENSG00000171307 E038 124.6429401 0.0027753167 4.990353e-01 7.001278e-01 10 97453799 97453846 48 + 1.989 2.024 0.119
ENSG00000171307 E039 497.5460626 0.0001682579 4.432019e-03 3.155670e-02 10 97454714 97454799 86 + 2.650 2.604 -0.154
ENSG00000171307 E040 81.9757492 0.0066291784 2.520756e-01 4.901389e-01 10 97455602 97455638 37 + 1.883 1.818 -0.221
ENSG00000171307 E041 75.1501283 0.0036561310 1.848367e-01 4.102757e-01 10 97455639 97455659 21 + 1.847 1.779 -0.230
ENSG00000171307 E042 413.4449505 0.0019686383 3.563668e-02 1.432932e-01 10 97455660 97455713 54 + 2.576 2.520 -0.188
ENSG00000171307 E043 350.6641091 0.0017687747 1.403101e-02 7.445982e-02 10 97455714 97455716 3 + 2.513 2.446 -0.225
ENSG00000171307 E044 577.0491125 0.0008023973 9.154395e-03 5.451197e-02 10 97455717 97455783 67 + 2.716 2.667 -0.165
ENSG00000171307 E045 577.2876424 0.0001819286 5.939057e-01 7.662940e-01 10 97455974 97456044 71 + 2.681 2.679 -0.005
ENSG00000171307 E046 30.2638311 0.1160205286 2.204827e-01 4.540867e-01 10 97456045 97456428 384 + 1.549 1.365 -0.634
ENSG00000171307 E047 1447.1425045 0.0012868366 7.275644e-01 8.528063e-01 10 97456777 97457922 1146 + 3.066 3.079 0.043