ENSG00000171302

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302345 ENSG00000171302 HEK293_OSMI2_6hA HEK293_TMG_6hB CANT1 protein_coding protein_coding 52.41519 72.97815 33.29903 7.104979 1.177159 -1.131749 17.21720 22.413572 12.76327 0.9668784 0.4423594 -0.8118878 0.3387833 0.31080000 0.3844 0.07360000 0.473696747 0.002419461 FALSE TRUE
ENST00000392446 ENSG00000171302 HEK293_OSMI2_6hA HEK293_TMG_6hB CANT1 protein_coding protein_coding 52.41519 72.97815 33.29903 7.104979 1.177159 -1.131749 28.02007 41.227389 13.66552 4.8979615 0.9490475 -1.5923570 0.5139625 0.56230000 0.4094 -0.15290000 0.002419461 0.002419461 FALSE TRUE
MSTRG.15196.7 ENSG00000171302 HEK293_OSMI2_6hA HEK293_TMG_6hB CANT1 protein_coding   52.41519 72.97815 33.29903 7.104979 1.177159 -1.131749 1.15040 1.143174 2.68029 1.1431739 0.4391743 1.2221515 0.0277375 0.01403333 0.0808 0.06676667 0.173542967 0.002419461 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171302 E001 3.1825068 0.069686386 0.005858750 0.03904370 17 78991716 78991716 1 - 0.000 0.699 12.600
ENSG00000171302 E002 3.1825068 0.069686386 0.005858750 0.03904370 17 78991717 78991719 3 - 0.000 0.699 12.595
ENSG00000171302 E003 17.7319401 0.013971681 0.001640576 0.01460323 17 78991720 78991726 7 - 0.836 1.315 1.749
ENSG00000171302 E004 43.6292867 0.072119002 0.021678907 0.10153834 17 78991727 78991768 42 - 1.276 1.671 1.359
ENSG00000171302 E005 95.8286232 0.263002572 0.104005700 0.28884935 17 78991769 78991805 37 - 1.639 2.002 1.227
ENSG00000171302 E006 304.8079211 0.986242673 0.361069628 0.59652146 17 78991806 78991912 107 - 2.218 2.487 0.899
ENSG00000171302 E007 603.5477354 1.267026879 0.417848594 0.64201780 17 78991913 78992140 228 - 2.527 2.780 0.841
ENSG00000171302 E008 481.8675412 1.173801078 0.395581258 0.62487253 17 78992141 78992409 269 - 2.424 2.684 0.866
ENSG00000171302 E009 630.0287737 1.319416607 0.474439321 0.68315577 17 78992410 78992761 352 - 2.586 2.790 0.680
ENSG00000171302 E010 510.1008433 1.236605919 0.460693016 0.67366366 17 78992762 78992980 219 - 2.493 2.699 0.686
ENSG00000171302 E011 873.9308476 1.447058559 0.498429820 0.69973503 17 78992981 78993486 506 - 2.735 2.931 0.650
ENSG00000171302 E012 656.1642973 1.367525906 0.527556183 0.72029630 17 78993487 78993783 297 - 2.641 2.799 0.526
ENSG00000171302 E013 352.7229520 1.081233268 0.422795663 0.64570472 17 78993784 78993920 137 - 2.322 2.542 0.734
ENSG00000171302 E014 579.9747502 0.033549419 0.230170488 0.46532188 17 78995018 78995221 204 - 2.691 2.716 0.084
ENSG00000171302 E015 1.3623117 0.012989884 0.471331928   17 78995222 78995249 28 - 0.186 0.374 1.359
ENSG00000171302 E016 2.5752817 0.032706255 0.089798548 0.26342820 17 78996976 78996991 16 - 0.186 0.594 2.453
ENSG00000171302 E017 531.2842021 0.072796561 0.116248102 0.30955132 17 78996992 78997105 114 - 2.718 2.653 -0.218
ENSG00000171302 E018 564.2804402 0.067242071 0.084729988 0.25420310 17 78997106 78997329 224 - 2.751 2.676 -0.248
ENSG00000171302 E019 195.8667107 0.058910984 0.176905144 0.39961375 17 78997330 78997392 63 - 2.263 2.230 -0.108
ENSG00000171302 E020 111.6868304 0.013433596 0.109512026 0.29827366 17 78997393 78997426 34 - 1.996 1.999 0.011
ENSG00000171302 E021 57.4707845 0.018084149 0.196533057 0.42521860 17 78997427 78997439 13 - 1.718 1.716 -0.009
ENSG00000171302 E022 94.1086221 0.018432544 0.138634775 0.34543868 17 78997440 78997490 51 - 1.925 1.924 -0.002
ENSG00000171302 E023 102.3384435 0.027272909 0.176550844 0.39914790 17 78997491 78997506 16 - 1.960 1.960 0.002
ENSG00000171302 E024 147.8266386 0.037345937 0.169702789 0.39011082 17 78997507 78997576 70 - 2.126 2.116 -0.034
ENSG00000171302 E025 208.4354798 0.024117404 0.084170585 0.25312735 17 78997577 78997644 68 - 2.277 2.263 -0.046
ENSG00000171302 E026 60.1126012 0.041039185 0.038592194 0.15111326 17 78997645 78997665 21 - 1.806 1.702 -0.352
ENSG00000171302 E027 117.2325445 0.031742358 0.036333632 0.14514906 17 78997666 78997774 109 - 2.071 1.997 -0.246
ENSG00000171302 E028 104.3432903 0.043843270 0.016072285 0.08207619 17 78997775 78997839 65 - 2.063 1.928 -0.454
ENSG00000171302 E029 304.0009382 0.052507127 0.139552014 0.34681332 17 78997840 78997963 124 - 2.454 2.420 -0.115
ENSG00000171302 E030 7.0059856 0.105875329 0.131627843 0.33438198 17 78998148 78998228 81 - 0.981 0.818 -0.620
ENSG00000171302 E031 4.3703262 0.006963033 0.058575579 0.19960214 17 78998229 78998286 58 - 0.836 0.635 -0.824
ENSG00000171302 E032 0.9105353 0.017267182 0.568411471   17 78998287 78998293 7 - 0.315 0.250 -0.451
ENSG00000171302 E033 19.4560936 0.002105065 0.032715144 0.13525950 17 79000100 79000270 171 - 1.327 1.231 -0.339
ENSG00000171302 E034 3.7555185 0.048134259 0.542957348 0.73117785 17 79005372 79005481 110 - 0.674 0.647 -0.114
ENSG00000171302 E035 1.8913889 0.421566726 0.567135187 0.74811036 17 79005957 79006213 257 - 0.416 0.421 0.031
ENSG00000171302 E036 2.0173404 0.010463546 0.156717783 0.37184291 17 79008063 79008171 109 - 0.564 0.374 -0.962
ENSG00000171302 E037 217.2997406 0.049201853 0.314321767 0.55453935 17 79009664 79009867 204 - 2.272 2.289 0.056