ENSG00000171241

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303383 ENSG00000171241 HEK293_OSMI2_6hA HEK293_TMG_6hB SHCBP1 protein_coding protein_coding 15.00559 8.205544 22.58458 1.437109 0.4156157 1.459548 6.685407 3.5732246 10.516489 0.6941935 0.6656529 1.5546940 0.44272083 0.43203333 0.4666667 0.03463333 0.8934079313 0.0001551154 FALSE TRUE
ENST00000564272 ENSG00000171241 HEK293_OSMI2_6hA HEK293_TMG_6hB SHCBP1 protein_coding processed_transcript 15.00559 8.205544 22.58458 1.437109 0.4156157 1.459548 3.530445 3.1242343 2.299730 0.8571130 0.2937011 -0.4403887 0.28118750 0.36373333 0.1019333 -0.26180000 0.0001551154 0.0001551154   FALSE
ENST00000566016 ENSG00000171241 HEK293_OSMI2_6hA HEK293_TMG_6hB SHCBP1 protein_coding retained_intron 15.00559 8.205544 22.58458 1.437109 0.4156157 1.459548 2.195684 0.4314742 4.408603 0.2184773 0.7713097 3.3231892 0.11442083 0.06196667 0.1943333 0.13236667 0.5548022142 0.0001551154 FALSE TRUE
ENST00000567698 ENSG00000171241 HEK293_OSMI2_6hA HEK293_TMG_6hB SHCBP1 protein_coding retained_intron 15.00559 8.205544 22.58458 1.437109 0.4156157 1.459548 1.420402 0.3742531 3.231834 0.3742531 0.7472092 3.0766813 0.09660417 0.06976667 0.1419667 0.07220000 0.3869518870 0.0001551154   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171241 E001 399.280792 0.0002178217 4.735390e-03 3.319210e-02 16 46578591 46581912 3322 - 2.546 2.596 0.167
ENSG00000171241 E002 143.453839 0.0003930555 4.292984e-01 6.505055e-01 16 46581913 46582054 142 - 2.110 2.134 0.082
ENSG00000171241 E003 110.697255 0.0004063725 2.640168e-01 5.032790e-01 16 46583516 46583657 142 - 2.017 1.975 -0.141
ENSG00000171241 E004 68.468165 0.0017181101 5.027612e-01 7.026674e-01 16 46584003 46584089 87 - 1.789 1.820 0.105
ENSG00000171241 E005 1.586861 0.3220492782 7.521895e-02 2.352556e-01 16 46584090 46584253 164 - 0.204 0.663 2.585
ENSG00000171241 E006 71.486756 0.0006085079 7.436876e-01 8.627747e-01 16 46595552 46595623 72 - 1.812 1.827 0.048
ENSG00000171241 E007 59.602076 0.0006474583 1.666833e-01 3.861281e-01 16 46595624 46595670 47 - 1.721 1.788 0.227
ENSG00000171241 E008 99.879460 0.0005078904 4.767563e-01 6.848429e-01 16 46599831 46599928 98 - 1.973 1.945 -0.093
ENSG00000171241 E009 71.380253 0.0005930714 3.181379e-02 1.326568e-01 16 46599929 46599962 34 - 1.847 1.746 -0.343
ENSG00000171241 E010 76.799502 0.0005032528 6.237085e-02 2.080944e-01 16 46603539 46603593 55 - 1.873 1.788 -0.285
ENSG00000171241 E011 83.881555 0.0012047471 7.251419e-01 8.512126e-01 16 46603594 46603659 66 - 1.884 1.899 0.051
ENSG00000171241 E012 3.731712 0.0811604297 7.935354e-01 8.923890e-01 16 46603660 46603974 315 - 0.625 0.667 0.180
ENSG00000171241 E013 61.339575 0.0006518878 8.405198e-01 9.197184e-01 16 46603975 46603989 15 - 1.752 1.762 0.033
ENSG00000171241 E014 109.029860 0.0003714179 5.432379e-01 7.313913e-01 16 46603990 46604143 154 - 2.007 1.984 -0.076
ENSG00000171241 E015 0.000000       16 46604144 46604227 84 -      
ENSG00000171241 E016 144.337083 0.0029514266 9.293197e-04 9.332378e-03 16 46604228 46604461 234 - 2.153 2.016 -0.460
ENSG00000171241 E017 102.886025 0.0016347075 2.133514e-03 1.796864e-02 16 46608297 46608389 93 - 2.007 1.874 -0.447
ENSG00000171241 E018 129.788593 0.0004153957 4.317472e-01 6.525392e-01 16 46615946 46616154 209 - 2.081 2.053 -0.092
ENSG00000171241 E019 79.205599 0.0009598690 1.735424e-01 3.952574e-01 16 46617634 46617749 116 - 1.879 1.816 -0.210
ENSG00000171241 E020 83.144025 0.0006307716 6.670903e-01 8.144105e-01 16 46618205 46618372 168 - 1.889 1.871 -0.062
ENSG00000171241 E021 25.536194 0.0025343051 2.417931e-17 4.977217e-15 16 46620466 46620900 435 - 1.124 1.720 2.067
ENSG00000171241 E022 45.353652 0.0041518185 2.525409e-03 2.050060e-02 16 46621257 46621379 123 - 1.567 1.755 0.637