ENSG00000171208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303155 ENSG00000171208 HEK293_OSMI2_6hA HEK293_TMG_6hB NETO2 protein_coding protein_coding 29.64474 13.03416 43.65966 1.975485 1.275998 1.743227 11.7208861 5.074023 15.367205 0.6203619 0.7048450 1.596751 0.4104417 0.3945667 0.3517000 -0.04286667 7.544267e-01 4.237658e-13 FALSE  
ENST00000562559 ENSG00000171208 HEK293_OSMI2_6hA HEK293_TMG_6hB NETO2 protein_coding protein_coding 29.64474 13.03416 43.65966 1.975485 1.275998 1.743227 6.6148005 3.583808 9.773281 0.7251843 0.6986727 1.444805 0.2356958 0.2706667 0.2234333 -0.04723333 6.916303e-01 4.237658e-13 FALSE  
ENST00000563078 ENSG00000171208 HEK293_OSMI2_6hA HEK293_TMG_6hB NETO2 protein_coding protein_coding 29.64474 13.03416 43.65966 1.975485 1.275998 1.743227 0.3812608 0.000000 3.050086 0.0000000 0.2787755 8.257429 0.0087250 0.0000000 0.0698000 0.06980000 4.237658e-13 4.237658e-13 FALSE  
MSTRG.12570.6 ENSG00000171208 HEK293_OSMI2_6hA HEK293_TMG_6hB NETO2 protein_coding   29.64474 13.03416 43.65966 1.975485 1.275998 1.743227 7.1411318 2.634403 11.253289 0.5695034 0.5105791 2.090614 0.2268667 0.1976000 0.2576000 0.06000000 4.894005e-01 4.237658e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171208 E001 39.888422 0.0028961244 0.336530852 0.57496347 16 47077703 47081633 3931 - 1.543 1.607 0.218
ENSG00000171208 E002 354.974090 0.0002078232 0.898600217 0.95113520 16 47081634 47082989 1356 - 2.502 2.506 0.014
ENSG00000171208 E003 190.785402 0.0002751390 0.011255224 0.06342356 16 47082990 47083106 117 - 2.212 2.284 0.241
ENSG00000171208 E004 222.022813 0.0002422114 0.001347942 0.01251978 16 47083107 47083248 142 - 2.274 2.358 0.280
ENSG00000171208 E005 340.966645 0.0010258836 0.002564378 0.02074653 16 47083249 47083613 365 - 2.465 2.540 0.249
ENSG00000171208 E006 117.647377 0.0004796349 0.603360255 0.77245029 16 47083614 47083696 83 - 2.020 2.041 0.069
ENSG00000171208 E007 148.533263 0.0003086818 0.435972344 0.65576181 16 47083697 47083801 105 - 2.133 2.110 -0.079
ENSG00000171208 E008 110.111483 0.0003982300 0.038564865 0.15103201 16 47086226 47086339 114 - 1.974 2.051 0.259
ENSG00000171208 E009 4.667588 0.0061842639 0.353943295 0.59078083 16 47100948 47100980 33 - 0.760 0.618 -0.593
ENSG00000171208 E010 109.885367 0.0003644176 0.939428253 0.97193620 16 47109483 47109530 48 - 1.997 2.001 0.015
ENSG00000171208 E011 220.395461 0.0002289363 0.877700456 0.94008337 16 47109531 47109711 181 - 2.298 2.296 -0.007
ENSG00000171208 E012 221.327856 0.0003577215 0.025577928 0.11400243 16 47122657 47122776 120 - 2.314 2.255 -0.197
ENSG00000171208 E013 113.563986 0.0016289455 0.042990339 0.16252417 16 47122777 47122784 8 - 2.033 1.951 -0.277
ENSG00000171208 E014 107.582362 0.0003888539 0.144444578 0.35407061 16 47122868 47122888 21 - 2.000 1.946 -0.183
ENSG00000171208 E015 127.542586 0.0010823867 0.026269355 0.11612542 16 47122889 47122912 24 - 2.080 1.997 -0.279
ENSG00000171208 E016 197.174752 0.0003190227 0.009968852 0.05803025 16 47128325 47128450 126 - 2.266 2.193 -0.243
ENSG00000171208 E017 181.377305 0.0002550639 0.014948750 0.07789394 16 47128451 47128573 123 - 2.232 2.161 -0.236
ENSG00000171208 E018 182.742915 0.0002745025 0.009583007 0.05632633 16 47129224 47129364 141 - 2.235 2.160 -0.252
ENSG00000171208 E019 90.112464 0.0111680928 0.819735208 0.90793262 16 47131969 47132025 57 - 1.908 1.923 0.050
ENSG00000171208 E020 3.517876 0.2825853174 0.209122129 0.44084693 16 47134070 47134410 341 - 0.508 0.805 1.278
ENSG00000171208 E021 70.475916 0.0007747918 0.018908533 0.09212258 16 47143579 47143976 398 - 1.776 1.884 0.366