ENSG00000171109

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000467174 ENSG00000171109 HEK293_OSMI2_6hA HEK293_TMG_6hB MFN1 protein_coding protein_coding 12.345 1.774669 21.74357 0.407372 2.157731 3.607523 2.6547158 0.00000000 5.497063 0.00000000 0.96421171 9.105139 0.1172583 0.00000000 0.24973333 0.2497333 2.322873e-09 2.322873e-09 FALSE FALSE
ENST00000471841 ENSG00000171109 HEK293_OSMI2_6hA HEK293_TMG_6hB MFN1 protein_coding protein_coding 12.345 1.774669 21.74357 0.407372 2.157731 3.607523 6.1150283 1.48304438 11.131355 0.25669912 0.07393561 2.899596 0.6122625 0.86046667 0.52203333 -0.3384333 5.739502e-02 2.322873e-09 FALSE TRUE
ENST00000489329 ENSG00000171109 HEK293_OSMI2_6hA HEK293_TMG_6hB MFN1 protein_coding protein_coding 12.345 1.774669 21.74357 0.407372 2.157731 3.607523 1.7603973 0.00000000 2.488044 0.00000000 1.25944364 7.964655 0.0760000 0.00000000 0.10493333 0.1049333 6.068172e-01 2.322873e-09 FALSE FALSE
MSTRG.24107.1 ENSG00000171109 HEK293_OSMI2_6hA HEK293_TMG_6hB MFN1 protein_coding   12.345 1.774669 21.74357 0.407372 2.157731 3.607523 0.7849781 0.06673331 1.010582 0.03857526 0.12071686 3.733395 0.1026750 0.03376667 0.04796667 0.0142000 9.026560e-01 2.322873e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000171109 E001 0.2922838 0.0256010444 1.456241e-01   3 179347703 179347708 6 + 0.048 0.274 2.902
ENSG00000171109 E002 4.2431981 0.0071588071 5.950425e-01 7.670796e-01 3 179347709 179347734 26 + 0.556 0.656 0.443
ENSG00000171109 E003 51.8840474 0.0007063736 3.510536e-01 5.881819e-01 3 179347735 179347810 76 + 1.548 1.479 -0.237
ENSG00000171109 E004 0.1779838 0.0348575029 7.401963e-01   3 179348050 179348121 72 + 0.048 0.000 -8.322
ENSG00000171109 E005 0.1614157 0.0341935557 7.402323e-01   3 179348761 179348844 84 + 0.048 0.000 -8.327
ENSG00000171109 E006 43.8388937 0.0008033187 4.028757e-01 6.306696e-01 3 179348845 179348847 3 + 1.477 1.410 -0.231
ENSG00000171109 E007 81.9168944 0.0004614243 4.423316e-01 6.602916e-01 3 179348848 179348963 116 + 1.739 1.695 -0.151
ENSG00000171109 E008 92.3521212 0.0004216479 7.619302e-01 8.737790e-01 3 179351900 179352035 136 + 1.788 1.773 -0.051
ENSG00000171109 E009 92.4354659 0.0004648862 1.699435e-01 3.903840e-01 3 179358840 179359002 163 + 1.795 1.718 -0.260
ENSG00000171109 E010 0.1779838 0.0348575029 7.401963e-01   3 179359720 179359860 141 + 0.048 0.000 -8.322
ENSG00000171109 E011 78.4467768 0.0006726524 3.637151e-02 1.452497e-01 3 179362358 179362482 125 + 1.733 1.600 -0.450
ENSG00000171109 E012 75.9734679 0.0006192071 9.523669e-02 2.733912e-01 3 179364297 179364405 109 + 1.715 1.610 -0.359
ENSG00000171109 E013 79.6160447 0.0022527302 1.361122e-01 3.415234e-01 3 179365118 179365225 108 + 1.734 1.637 -0.328
ENSG00000171109 E014 94.9853415 0.0004525564 1.059989e-02 6.067498e-02 3 179367439 179367592 154 + 1.812 1.663 -0.505
ENSG00000171109 E015 64.3317103 0.0070144684 5.367867e-01 7.268815e-01 3 179368036 179368103 68 + 1.638 1.590 -0.164
ENSG00000171109 E016 90.2317595 0.0005729314 7.131982e-01 8.438065e-01 3 179375220 179375341 122 + 1.779 1.759 -0.065
ENSG00000171109 E017 1.7383863 0.0109294485 7.928214e-01 8.920622e-01 3 179376922 179377041 120 + 0.338 0.275 -0.419
ENSG00000171109 E018 49.7041891 0.0008149777 7.197304e-01 8.480476e-01 3 179377042 179377061 20 + 1.521 1.549 0.096
ENSG00000171109 E019 68.9866150 0.0006276669 6.539450e-01 8.060540e-01 3 179377062 179377129 68 + 1.664 1.637 -0.093
ENSG00000171109 E020 46.7056426 0.0008044421 6.612643e-01 8.107190e-01 3 179377130 179377168 39 + 1.499 1.466 -0.113
ENSG00000171109 E021 0.7860845 0.0171875916 7.139504e-01   3 179377169 179377343 175 + 0.201 0.000 -10.747
ENSG00000171109 E022 40.0723895 0.0009612490 9.104779e-01 9.573585e-01 3 179377344 179377448 105 + 1.429 1.439 0.036
ENSG00000171109 E023 49.9567274 0.0008890270 6.814083e-01 8.235452e-01 3 179378341 179378443 103 + 1.518 1.549 0.107
ENSG00000171109 E024 2.1489143 0.0101754961 3.159868e-01 5.559987e-01 3 179378444 179378584 141 + 0.361 0.562 1.029
ENSG00000171109 E025 92.0220173 0.0008138848 8.672028e-01 9.344482e-01 3 179378585 179378814 230 + 1.782 1.792 0.034
ENSG00000171109 E026 85.7979549 0.0231700452 9.325262e-01 9.684297e-01 3 179385569 179385721 153 + 1.757 1.755 -0.006
ENSG00000171109 E027 98.9203761 0.0004509728 2.918702e-01 5.325356e-01 3 179386433 179386629 197 + 1.810 1.865 0.187
ENSG00000171109 E028 88.2276098 0.0007456361 6.308404e-01 7.909339e-01 3 179390004 179390138 135 + 1.764 1.792 0.094
ENSG00000171109 E029 294.7174863 0.0003918660 4.017974e-08 1.637889e-06 3 179391981 179394936 2956 + 2.263 2.413 0.500