ENSG00000170889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302907 ENSG00000170889 HEK293_OSMI2_6hA HEK293_TMG_6hB RPS9 protein_coding protein_coding 3516.108 5443.843 1681.244 1460.451 73.24744 -1.69509 3150.337 4923.3384 1387.8826 1325.42292 29.96802 -1.82674394 0.87434583 0.90463333 0.82713333 -0.0775 0.06024628 1.063816e-10 FALSE  
ENST00000626547 ENSG00000170889 HEK293_OSMI2_6hA HEK293_TMG_6hB RPS9 protein_coding protein_coding 3516.108 5443.843 1681.244 1460.451 73.24744 -1.69509 114.142 158.7436 164.9405 59.61704 39.53726 0.05524334 0.05172917 0.02813333 0.09633333 0.0682 0.03709485 1.063816e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170889 E001 1.125326e+00 5.264030e-01 2.993530e-01   19 54200799 54200799 1 + 0.000 0.314 10.947
ENSG00000170889 E002 3.096580e+00 3.681198e-02 9.273488e-03 5.498591e-02 19 54200800 54200808 9 + 0.000 0.599 14.255
ENSG00000170889 E003 5.640328e+00 5.109657e-02 3.784375e-02 1.492057e-01 19 54200809 54200811 3 + 0.357 0.789 2.014
ENSG00000170889 E004 7.591682e+01 5.226746e-04 1.184092e-05 2.423892e-04 19 54200812 54200857 46 + 1.593 1.838 0.829
ENSG00000170889 E005 2.327301e+02 2.784320e-03 1.600700e-20 5.052708e-18 19 54200858 54200870 13 + 2.523 2.187 -1.120
ENSG00000170889 E006 2.791963e+02 2.342824e-03 1.562840e-26 9.312495e-24 19 54200871 54200871 1 + 2.611 2.260 -1.171
ENSG00000170889 E007 3.428799e+03 4.462331e-04 1.036029e-18 2.568489e-16 19 54200872 54200873 2 + 3.531 3.415 -0.384
ENSG00000170889 E008 7.225525e+03 3.520166e-04 5.473341e-36 6.936561e-33 19 54200874 54200878 5 + 3.867 3.734 -0.439
ENSG00000170889 E009 1.042844e+04 4.247472e-05 7.156922e-13 7.525758e-11 19 54200879 54200888 10 + 3.959 3.918 -0.137
ENSG00000170889 E010 8.529272e+02 3.221362e-04 6.573497e-02 2.156011e-01 19 54200889 54200893 5 + 2.868 2.834 -0.114
ENSG00000170889 E011 1.579268e+01 2.149004e-03 4.516723e-03 3.202553e-02 19 54200894 54200961 68 + 1.342 1.077 -0.938
ENSG00000170889 E012 1.469418e+02 9.378760e-04 1.660370e-02 8.398917e-02 19 54201133 54201159 27 + 2.004 2.096 0.308
ENSG00000170889 E013 2.349370e+04 1.280799e-04 2.189276e-04 2.880971e-03 19 54201160 54201281 122 + 4.298 4.270 -0.093
ENSG00000170889 E014 2.939459e+04 3.801091e-05 1.475373e-03 1.344453e-02 19 54201487 54201609 123 + 4.372 4.375 0.011
ENSG00000170889 E015 9.181560e+01 1.499280e-01 2.432789e-02 1.101099e-01 19 54201610 54202008 399 + 2.191 1.735 -1.532
ENSG00000170889 E016 3.073630e+01 2.241165e-01 1.673651e-02 8.449984e-02 19 54203237 54203275 39 + 1.787 1.221 -1.945
ENSG00000170889 E017 2.625117e+04 2.707117e-05 2.006073e-89 3.097067e-85 19 54206276 54206462 187 + 4.279 4.338 0.196
ENSG00000170889 E018 1.520179e+02 7.796375e-02 1.836708e-02 9.024804e-02 19 54206463 54206552 90 + 2.356 1.985 -1.240
ENSG00000170889 E019 2.267317e+02 6.653586e-02 1.430508e-02 7.553890e-02 19 54206553 54206619 67 + 2.520 2.162 -1.194
ENSG00000170889 E020 2.651392e+02 5.923063e-02 1.341387e-02 7.207212e-02 19 54206620 54206724 105 + 2.578 2.236 -1.143
ENSG00000170889 E021 5.006194e+02 1.138431e-01 5.477219e-02 1.908329e-01 19 54206725 54207397 673 + 2.857 2.508 -1.160
ENSG00000170889 E022 1.386871e+04 3.570078e-04 4.394090e-05 7.453977e-04 19 54207398 54207452 55 + 4.024 4.052 0.092
ENSG00000170889 E023 1.192541e+04 2.753599e-04 1.503462e-06 4.054839e-05 19 54207453 54207650 198 + 3.955 3.988 0.109
ENSG00000170889 E024 2.596811e+01 1.665331e-03 8.845660e-11 6.343735e-09 19 54231741 54231936 196 + 1.664 1.196 -1.618
ENSG00000170889 E025 1.779838e-01 4.092876e-02 1.164895e-01   19 54238042 54238222 181 + 0.214 0.000 -12.914
ENSG00000170889 E026 1.802579e+00 1.666216e-01 3.225835e-01 5.619674e-01 19 54247092 54249003 1912 + 0.213 0.423 1.383