ENSG00000170846

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307533 ENSG00000170846 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding nonsense_mediated_decay 53.51246 34.83152 55.39927 1.594628 2.242181 0.6693199 4.351806 2.703957 4.912813 0.3115192 0.3325116 0.8590854 0.08274167 0.07746667 0.08846667 0.01100000 8.324073e-01 1.403665e-05 TRUE FALSE
ENST00000635031 ENSG00000170846 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding protein_coding 53.51246 34.83152 55.39927 1.594628 2.242181 0.6693199 10.757067 7.231571 9.326413 0.3874536 0.4461739 0.3665657 0.20422500 0.20853333 0.16920000 -0.03933333 6.419660e-01 1.403665e-05 FALSE FALSE
MSTRG.24534.2 ENSG00000170846 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   53.51246 34.83152 55.39927 1.594628 2.242181 0.6693199 8.915074 1.287385 15.928026 0.4827142 0.4806641 3.6187947 0.16429583 0.03666667 0.28800000 0.25133333 1.403665e-05 1.403665e-05   FALSE
MSTRG.24534.8 ENSG00000170846 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   53.51246 34.83152 55.39927 1.594628 2.242181 0.6693199 14.650511 12.191747 10.353238 1.4358528 1.5092176 -0.2356130 0.27015833 0.35093333 0.18556667 -0.16536667 9.324627e-02 1.403665e-05 TRUE FALSE
MSTRG.24534.9 ENSG00000170846 HEK293_OSMI2_6hA HEK293_TMG_6hB protein_coding   53.51246 34.83152 55.39927 1.594628 2.242181 0.6693199 14.174239 10.780690 14.452431 1.7817454 0.7654439 0.4225230 0.26605833 0.30780000 0.26110000 -0.04670000 8.312213e-01 1.403665e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170846 E001 0.000000       4 6663396 6663501 106 +      
ENSG00000170846 E002 0.000000       4 6663637 6663824 188 +      
ENSG00000170846 E003 0.000000       4 6673290 6673450 161 +      
ENSG00000170846 E004 149.027724 0.0889145293 4.787447e-02 1.747267e-01 4 6673451 6673837 387 + 2.340 1.921 -1.402
ENSG00000170846 E005 46.393177 0.4684232272 6.544308e-01 8.063602e-01 4 6673838 6673968 131 + 1.723 1.624 -0.337
ENSG00000170846 E006 36.598240 0.0060482972 8.960920e-02 2.630856e-01 4 6673969 6674087 119 + 1.570 1.587 0.060
ENSG00000170846 E007 122.352678 0.0008146006 4.724875e-14 6.258912e-12 4 6674088 6674480 393 + 2.003 2.159 0.524
ENSG00000170846 E008 73.941343 0.0023958033 3.033507e-13 3.434395e-11 4 6674481 6674551 71 + 1.730 1.975 0.825
ENSG00000170846 E009 83.822147 0.0064290250 7.985697e-09 3.837451e-07 4 6674552 6674637 86 + 1.805 2.020 0.723
ENSG00000170846 E010 76.854118 0.0061641411 5.946051e-02 2.015936e-01 4 6674638 6674706 69 + 1.886 1.894 0.027
ENSG00000170846 E011 114.000292 0.0096845582 2.062261e-01 4.372604e-01 4 6674707 6674992 286 + 2.134 1.974 -0.536
ENSG00000170846 E012 1248.338736 0.0046829298 4.983236e-02 1.792447e-01 4 6674993 6676018 1026 + 3.152 3.035 -0.390
ENSG00000170846 E013 47.486335 0.0008011844 1.172018e-02 6.532258e-02 4 6676019 6676755 737 + 1.787 1.561 -0.767
ENSG00000170846 E014 0.000000       4 6681569 6681615 47 +      
ENSG00000170846 E015 2.266095 0.6041672604 3.296307e-01 5.685923e-01 4 6687853 6688342 490 + 0.404 0.624 1.066