ENSG00000170832

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300896 ENSG00000170832 HEK293_OSMI2_6hA HEK293_TMG_6hB USP32 protein_coding protein_coding 7.475551 4.598446 11.63134 1.028556 0.4107048 1.336905 2.7714144 1.7110457 4.4753471 0.4817179 0.11938250 1.3819342 0.36777917 0.3636000 0.38516667 0.02156667 9.493500e-01 5.648682e-05 FALSE TRUE
ENST00000590133 ENSG00000170832 HEK293_OSMI2_6hA HEK293_TMG_6hB USP32 protein_coding protein_coding 7.475551 4.598446 11.63134 1.028556 0.4107048 1.336905 0.2634877 0.0000000 0.6014845 0.0000000 0.05131469 5.9342440 0.02471250 0.0000000 0.05183333 0.05183333 5.648682e-05 5.648682e-05 FALSE TRUE
ENST00000592339 ENSG00000170832 HEK293_OSMI2_6hA HEK293_TMG_6hB USP32 protein_coding protein_coding 7.475551 4.598446 11.63134 1.028556 0.4107048 1.336905 2.5928056 2.0951256 3.6190624 0.6565270 0.23823162 0.7856906 0.37951250 0.4288333 0.31143333 -0.11740000 5.291751e-01 5.648682e-05 FALSE TRUE
ENST00000593071 ENSG00000170832 HEK293_OSMI2_6hA HEK293_TMG_6hB USP32 protein_coding protein_coding 7.475551 4.598446 11.63134 1.028556 0.4107048 1.336905 0.2942334 0.0000000 0.0000000 0.0000000 0.00000000 0.0000000 0.05377083 0.0000000 0.00000000 0.00000000   5.648682e-05 FALSE FALSE
MSTRG.14818.4 ENSG00000170832 HEK293_OSMI2_6hA HEK293_TMG_6hB USP32 protein_coding   7.475551 4.598446 11.63134 1.028556 0.4107048 1.336905 1.1106714 0.5075586 2.1328421 0.1392053 0.33322065 2.0497314 0.11548750 0.1159000 0.18206667 0.06616667 5.834033e-01 5.648682e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170832 E001 121.4596617 0.0004047204 6.925747e-01 8.307502e-01 17 60177327 60179104 1778 - 2.066 2.054 -0.038
ENSG00000170832 E002 6.5763417 0.0299223972 7.080550e-01 8.405466e-01 17 60179105 60179110 6 - 0.848 0.898 0.189
ENSG00000170832 E003 24.7525051 0.0017402326 1.361045e-01 3.415147e-01 17 60179111 60179168 58 - 1.354 1.464 0.380
ENSG00000170832 E004 83.7977065 0.0020025109 1.207187e-03 1.148569e-02 17 60179169 60179428 260 - 1.848 1.994 0.488
ENSG00000170832 E005 58.3359150 0.0029135954 1.336039e-05 2.696259e-04 17 60180545 60180637 93 - 1.653 1.886 0.787
ENSG00000170832 E006 125.9348420 0.0003502810 1.785412e-06 4.715481e-05 17 60181324 60181748 425 - 2.020 2.175 0.519
ENSG00000170832 E007 36.4385481 0.0022714232 3.578066e-02 1.436598e-01 17 60183165 60183185 21 - 1.497 1.630 0.453
ENSG00000170832 E008 87.1877647 0.0062918717 3.131495e-02 1.312612e-01 17 60183186 60183453 268 - 1.876 1.990 0.383
ENSG00000170832 E009 61.1075763 0.0065442842 4.569129e-01 6.709410e-01 17 60185460 60185651 192 - 1.752 1.792 0.134
ENSG00000170832 E010 1.1771411 0.4930699243 7.849853e-01   17 60185652 60185933 282 - 0.282 0.384 0.638
ENSG00000170832 E011 51.2931122 0.0007879332 1.279254e-01 3.285346e-01 17 60190563 60190683 121 - 1.665 1.745 0.269
ENSG00000170832 E012 52.9134132 0.0009212807 1.995769e-01 4.291277e-01 17 60192844 60192930 87 - 1.688 1.755 0.227
ENSG00000170832 E013 76.9164815 0.0049386740 1.055671e-01 2.916024e-01 17 60198260 60198444 185 - 1.839 1.928 0.300
ENSG00000170832 E014 73.5732463 0.0006223323 8.604074e-01 9.305672e-01 17 60205447 60205658 212 - 1.847 1.858 0.035
ENSG00000170832 E015 42.4002073 0.0010069418 8.213733e-01 9.087705e-01 17 60207021 60207132 112 - 1.616 1.605 -0.038
ENSG00000170832 E016 0.0000000       17 60207729 60208058 330 -      
ENSG00000170832 E017 20.4480417 0.0016322765 6.825760e-01 8.243351e-01 17 60208059 60208210 152 - 1.294 1.329 0.122
ENSG00000170832 E018 29.7695569 0.0138745839 6.464475e-01 8.011446e-01 17 60208654 60208828 175 - 1.472 1.426 -0.158
ENSG00000170832 E019 26.9000969 0.0016921556 1.078880e-01 2.955377e-01 17 60209370 60209416 47 - 1.455 1.338 -0.403
ENSG00000170832 E020 33.5420962 0.0010942534 3.112173e-01 5.515973e-01 17 60209417 60209543 127 - 1.536 1.472 -0.218
ENSG00000170832 E021 30.4878482 0.0014790231 4.674509e-02 1.719325e-01 17 60211013 60211118 106 - 1.518 1.382 -0.469
ENSG00000170832 E022 35.8991708 0.0011919172 1.910146e-01 4.182019e-01 17 60211376 60211514 139 - 1.571 1.492 -0.272
ENSG00000170832 E023 26.0228099 0.0019679320 8.198843e-01 9.080104e-01 17 60212024 60212098 75 - 1.418 1.406 -0.044
ENSG00000170832 E024 17.3374985 0.0034596089 4.713085e-01 6.811020e-01 17 60213581 60213662 82 - 1.224 1.289 0.229
ENSG00000170832 E025 33.4923451 0.0017202498 6.012478e-01 7.709852e-01 17 60214620 60214774 155 - 1.530 1.498 -0.109
ENSG00000170832 E026 0.3336024 0.0244411696 6.788666e-02   17 60219571 60219627 57 - 0.000 0.284 12.354
ENSG00000170832 E027 1.1741770 0.0151038483 1.937086e-01   17 60219628 60219635 8 - 0.224 0.455 1.455
ENSG00000170832 E028 2.1374375 0.0100154379 3.274189e-01 5.664896e-01 17 60219636 60219669 34 - 0.411 0.577 0.815
ENSG00000170832 E029 24.3597483 0.0014617058 2.325367e-01 4.680929e-01 17 60219670 60219679 10 - 1.407 1.319 -0.306
ENSG00000170832 E030 47.6760633 0.0009048196 2.065052e-01 4.375307e-01 17 60219680 60219787 108 - 1.686 1.619 -0.226
ENSG00000170832 E031 53.0503190 0.0017125852 4.971194e-01 6.989911e-01 17 60222409 60222549 141 - 1.723 1.690 -0.113
ENSG00000170832 E032 53.9842545 0.0008056339 4.688177e-01 6.792655e-01 17 60223411 60223586 176 - 1.728 1.694 -0.115
ENSG00000170832 E033 44.7858927 0.0008385858 1.754505e-02 8.744357e-02 17 60226039 60226182 144 - 1.680 1.546 -0.455
ENSG00000170832 E034 26.6683499 0.0013110780 4.160810e-03 3.005535e-02 17 60226183 60226231 49 - 1.481 1.268 -0.738
ENSG00000170832 E035 44.5482579 0.0009215654 9.226765e-03 5.482564e-02 17 60236138 60236240 103 - 1.682 1.535 -0.501
ENSG00000170832 E036 0.1614157 0.0358091222 1.000000e+00   17 60249058 60249753 696 - 0.088 0.000 -9.317
ENSG00000170832 E037 37.4076402 0.0010843815 2.841936e-03 2.245608e-02 17 60252381 60252442 62 - 1.616 1.429 -0.641
ENSG00000170832 E038 37.1054319 0.0037177148 6.093357e-03 4.018142e-02 17 60255175 60255258 84 - 1.613 1.429 -0.632
ENSG00000170832 E039 0.0000000       17 60256631 60256700 70 -      
ENSG00000170832 E040 36.9900324 0.0084926984 5.244888e-02 1.853507e-01 17 60265412 60265474 63 - 1.596 1.452 -0.491
ENSG00000170832 E041 42.2017573 0.0096590487 2.395410e-01 4.761018e-01 17 60265976 60266091 116 - 1.637 1.549 -0.301
ENSG00000170832 E042 38.4175508 0.0012568888 6.734675e-01 8.185863e-01 17 60269450 60269557 108 - 1.579 1.557 -0.074
ENSG00000170832 E043 44.9585097 0.0009298513 4.615689e-01 6.742512e-01 17 60271350 60271481 132 - 1.652 1.615 -0.128
ENSG00000170832 E044 45.4701207 0.0009366365 1.403267e-01 3.480051e-01 17 60288523 60288682 160 - 1.665 1.585 -0.275
ENSG00000170832 E045 42.8975628 0.0142959347 5.512062e-01 7.371830e-01 17 60294683 60294801 119 - 1.636 1.574 -0.208
ENSG00000170832 E046 0.0000000       17 60301450 60301598 149 -      
ENSG00000170832 E047 34.9950163 0.0015933369 3.102361e-01 5.507148e-01 17 60301599 60301704 106 - 1.550 1.485 -0.221
ENSG00000170832 E048 0.0000000       17 60304907 60305043 137 -      
ENSG00000170832 E049 0.0000000       17 60305143 60305228 86 -      
ENSG00000170832 E050 36.3538177 0.0085390092 5.761665e-02 1.974420e-01 17 60345481 60345608 128 - 1.591 1.443 -0.509
ENSG00000170832 E051 24.6821631 0.0017039709 1.435803e-01 3.527668e-01 17 60391882 60392230 349 - 1.419 1.310 -0.380
ENSG00000170832 E052 0.3088520 0.0262632291 6.009152e-01   17 60392339 60392408 70 - 0.088 0.165 1.033
ENSG00000170832 E053 0.0000000       17 60421208 60421551 344 -      
ENSG00000170832 E054 0.0000000       17 60422246 60422470 225 -