ENSG00000170776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394510 ENSG00000170776 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP13 protein_coding protein_coding 7.199587 10.26066 5.497444 1.187284 0.1461419 -0.8990744 2.7543173 6.4817082 0.0000000 1.1851394 0.000000000 -9.3424543 0.32110000 0.62110000 0.0000000 -0.62110000 8.571494e-22 8.571494e-22 FALSE TRUE
ENST00000394518 ENSG00000170776 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP13 protein_coding protein_coding 7.199587 10.26066 5.497444 1.187284 0.1461419 -0.8990744 1.1516499 1.2812483 1.4625532 0.2049010 0.175329880 0.1895533 0.18831250 0.12986667 0.2649000 0.13503333 1.928522e-01 8.571494e-22 FALSE TRUE
ENST00000558644 ENSG00000170776 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP13 protein_coding retained_intron 7.199587 10.26066 5.497444 1.187284 0.1461419 -0.8990744 0.1421901 0.0000000 0.3945193 0.0000000 0.394519306 5.3381367 0.02607917 0.00000000 0.0685000 0.06850000 7.980013e-01 8.571494e-22 FALSE TRUE
ENST00000559391 ENSG00000170776 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP13 protein_coding retained_intron 7.199587 10.26066 5.497444 1.187284 0.1461419 -0.8990744 0.3403135 0.4906383 0.4193776 0.2483903 0.155408327 -0.2215217 0.05033333 0.04916667 0.0769000 0.02773333 8.660819e-01 8.571494e-22   FALSE
ENST00000560185 ENSG00000170776 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP13 protein_coding processed_transcript 7.199587 10.26066 5.497444 1.187284 0.1461419 -0.8990744 0.8307956 0.0000000 0.0000000 0.0000000 0.000000000 0.0000000 0.08565417 0.00000000 0.0000000 0.00000000   8.571494e-22   FALSE
ENST00000560579 ENSG00000170776 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP13 protein_coding protein_coding 7.199587 10.26066 5.497444 1.187284 0.1461419 -0.8990744 0.2330257 0.0000000 0.7369213 0.0000000 0.008069866 6.2228844 0.04291250 0.00000000 0.1342333 0.13423333 3.011208e-15 8.571494e-22 FALSE TRUE
MSTRG.11463.4 ENSG00000170776 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP13 protein_coding   7.199587 10.26066 5.497444 1.187284 0.1461419 -0.8990744 1.5209949 1.7309735 2.2149939 0.3731532 0.394070135 0.3539071 0.24957083 0.17046667 0.4066000 0.23613333 1.576356e-01 8.571494e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170776 E001 0.1426347 0.0315154194 2.007971e-01   15 85380571 85380586 16 + 0.157 0.000 -27.068
ENSG00000170776 E002 0.5767453 0.0199649000 8.646292e-01   15 85380587 85380594 8 + 0.158 0.234 0.704
ENSG00000170776 E003 0.5767453 0.0199649000 8.646292e-01   15 85380595 85380595 1 + 0.158 0.234 0.704
ENSG00000170776 E004 0.9998973 0.0555552384 9.778657e-01   15 85380596 85380602 7 + 0.273 0.337 0.426
ENSG00000170776 E005 1.6950042 0.0453193527 8.923958e-01 9.478027e-01 15 85380603 85380616 14 + 0.364 0.461 0.525
ENSG00000170776 E006 2.6654515 0.0086234944 2.685203e-01 5.081982e-01 15 85380617 85380625 9 + 0.364 0.636 1.341
ENSG00000170776 E007 3.8019962 0.0071575590 4.101472e-01 6.361134e-01 15 85380626 85380639 14 + 0.504 0.723 0.969
ENSG00000170776 E008 7.8978919 0.0040897327 7.989970e-01 8.956840e-01 15 85380640 85380728 89 + 0.879 0.947 0.258
ENSG00000170776 E009 8.3638059 0.0046304306 4.589068e-02 1.697774e-01 15 85380729 85380755 27 + 1.027 0.898 -0.481
ENSG00000170776 E010 8.5751839 0.0039823030 8.654164e-03 5.227931e-02 15 85380756 85380798 43 + 1.077 0.884 -0.717
ENSG00000170776 E011 0.4054685 0.5143601116 7.175105e-01   15 85381687 85382170 484 + 0.000 0.178 26.379
ENSG00000170776 E012 0.2735028 0.0261045285 5.237915e-01   15 85480873 85481026 154 + 0.157 0.093 -0.880
ENSG00000170776 E013 9.3417243 0.0674546169 7.009451e-02 2.249836e-01 15 85485710 85485753 44 + 1.096 0.925 -0.628
ENSG00000170776 E014 15.8702110 0.0105272485 9.832507e-05 1.474555e-03 15 85521428 85521575 148 + 1.359 1.095 -0.936
ENSG00000170776 E015 24.5886226 0.0501949374 1.161351e-06 3.233793e-05 15 85533584 85533880 297 + 1.644 1.138 -1.759
ENSG00000170776 E016 2.3055448 0.2619120068 7.814389e-01 8.855059e-01 15 85533881 85536997 3117 + 0.438 0.515 0.385
ENSG00000170776 E017 19.1790602 0.0396709532 6.626530e-04 7.121936e-03 15 85543772 85543955 184 + 1.450 1.155 -1.032
ENSG00000170776 E018 0.0000000       15 85544040 85544143 104 +      
ENSG00000170776 E019 0.0000000       15 85555446 85555491 46 +      
ENSG00000170776 E020 24.7279891 0.0038704798 1.200983e-06 3.329027e-05 15 85575131 85575329 199 + 1.535 1.281 -0.877
ENSG00000170776 E021 258.2621797 0.0085272024 2.471938e-13 2.861567e-11 15 85578930 85582107 3178 + 2.530 2.299 -0.771
ENSG00000170776 E022 0.0000000       15 85582910 85583164 255 +      
ENSG00000170776 E023 32.3842339 0.0158243598 1.500211e-02 7.808813e-02 15 85585702 85585823 122 + 1.566 1.477 -0.307
ENSG00000170776 E024 0.0000000       15 85619696 85619949 254 +      
ENSG00000170776 E025 0.0000000       15 85619950 85620172 223 +      
ENSG00000170776 E026 0.0000000       15 85635097 85635105 9 +      
ENSG00000170776 E027 30.1104596 0.0015069170 4.586116e-02 1.697052e-01 15 85639374 85639449 76 + 1.494 1.470 -0.082
ENSG00000170776 E028 33.3507440 0.0107635511 1.247555e-03 1.177496e-02 15 85645818 85645918 101 + 1.602 1.467 -0.462
ENSG00000170776 E029 24.1403421 0.0029193757 3.700932e-05 6.455457e-04 15 85645919 85645954 36 + 1.500 1.306 -0.672
ENSG00000170776 E030 67.4112714 0.0161223202 2.164357e-03 1.817073e-02 15 85655417 85655787 371 + 1.881 1.773 -0.364
ENSG00000170776 E031 10.0980129 0.0706490964 5.081305e-01 7.065374e-01 15 85658537 85658590 54 + 1.011 1.021 0.038
ENSG00000170776 E032 0.8674813 0.9453699695 9.853030e-01   15 85662388 85662453 66 + 0.161 0.299 1.137
ENSG00000170776 E033 47.6742696 0.0382609628 5.610395e-02 1.938634e-01 15 85664563 85664755 193 + 1.718 1.633 -0.286
ENSG00000170776 E034 41.5859993 0.0102506896 7.365830e-03 4.638930e-02 15 85669722 85669830 109 + 1.659 1.580 -0.269
ENSG00000170776 E035 0.1779838 0.0634721855 2.016876e-01   15 85677037 85677098 62 + 0.158 0.000 -27.089
ENSG00000170776 E036 20.7450894 0.0032467697 3.676411e-01 6.021267e-01 15 85682158 85682167 10 + 1.297 1.331 0.121
ENSG00000170776 E037 28.2908397 0.0015558426 8.487734e-02 2.543789e-01 15 85682168 85682212 45 + 1.449 1.438 -0.038
ENSG00000170776 E038 0.1614157 0.0315285689 2.006706e-01   15 85683527 85683612 86 + 0.158 0.000 -27.086
ENSG00000170776 E039 0.1779838 0.0634721855 2.016876e-01   15 85684422 85684740 319 + 0.158 0.000 -27.089
ENSG00000170776 E040 42.7755339 0.0046834895 2.603602e-01 4.993242e-01 15 85684741 85684873 133 + 1.592 1.631 0.133
ENSG00000170776 E041 0.0000000       15 85684874 85685446 573 +      
ENSG00000170776 E042 0.0000000       15 85689869 85690104 236 +      
ENSG00000170776 E043 0.0000000       15 85693099 85693276 178 +      
ENSG00000170776 E044 49.3679691 0.0051738611 6.933360e-01 8.312523e-01 15 85693277 85693451 175 + 1.620 1.705 0.292
ENSG00000170776 E045 28.6811901 0.0324368098 1.636775e-01 3.821986e-01 15 85708019 85708086 68 + 1.471 1.439 -0.110
ENSG00000170776 E046 0.2922838 0.0260389555 5.235151e-01   15 85710443 85710578 136 + 0.158 0.093 -0.882
ENSG00000170776 E047 15.3984116 0.0447111558 3.179490e-01 5.578865e-01 15 85710579 85710581 3 + 1.204 1.188 -0.055
ENSG00000170776 E048 31.6447504 0.0387357157 1.068644e-01 2.937940e-01 15 85710582 85710645 64 + 1.531 1.471 -0.206
ENSG00000170776 E049 50.1647598 0.0275953408 8.247167e-02 2.496700e-01 15 85715788 85715923 136 + 1.712 1.673 -0.131
ENSG00000170776 E050 0.0000000       15 85717152 85717289 138 +      
ENSG00000170776 E051 45.2970427 0.0141422018 7.027209e-03 4.476804e-02 15 85717290 85717402 113 + 1.700 1.610 -0.305
ENSG00000170776 E052 12.6106292 0.0304333273 2.155861e-01 4.481484e-01 15 85718007 85718012 6 + 1.136 1.091 -0.162
ENSG00000170776 E053 51.9590551 0.0109939955 4.773162e-02 1.743848e-01 15 85718013 85718159 147 + 1.718 1.692 -0.089
ENSG00000170776 E054 0.0000000       15 85718801 85718875 75 +      
ENSG00000170776 E055 47.7261719 0.0019271155 3.030091e-01 5.435721e-01 15 85719076 85719211 136 + 1.633 1.685 0.174
ENSG00000170776 E056 51.0772722 0.0009742040 1.384493e-01 3.451821e-01 15 85719212 85719326 115 + 1.675 1.707 0.108
ENSG00000170776 E057 56.9255291 0.0028470349 8.550026e-02 2.555301e-01 15 85721991 85722116 126 + 1.732 1.751 0.065
ENSG00000170776 E058 0.1308682 0.0313767526 1.000000e+00   15 85722117 85722229 113 + 0.000 0.092 25.289
ENSG00000170776 E059 61.1133869 0.0040096066 4.475766e-04 5.201451e-03 15 85722230 85722347 118 + 1.823 1.748 -0.255
ENSG00000170776 E060 96.0379382 0.0004643139 1.307539e-01 3.329836e-01 15 85723072 85723320 249 + 1.931 1.984 0.177
ENSG00000170776 E061 48.0853418 0.3794743342 2.856928e-01 5.262970e-01 15 85726410 85726486 77 + 1.470 1.748 0.949
ENSG00000170776 E062 67.4021918 0.2389330747 3.265878e-01 5.657669e-01 15 85727066 85727247 182 + 1.662 1.878 0.729
ENSG00000170776 E063 45.3318388 0.0013068149 9.674722e-01 9.856680e-01 15 85727381 85727463 83 + 1.577 1.684 0.365
ENSG00000170776 E064 67.6864429 0.0011280451 3.281501e-01 5.671657e-01 15 85730513 85730707 195 + 1.775 1.840 0.218
ENSG00000170776 E065 75.2584656 0.0006991737 9.266532e-01 9.653969e-01 15 85734992 85735150 159 + 1.785 1.892 0.360
ENSG00000170776 E066 47.2727667 0.0024758809 8.967633e-01 9.501908e-01 15 85735560 85735598 39 + 1.587 1.690 0.350
ENSG00000170776 E067 41.4626920 0.0016449990 9.887217e-01 9.961596e-01 15 85735599 85735630 32 + 1.529 1.639 0.376
ENSG00000170776 E068 34.9349544 0.0012467539 7.375762e-01 8.589923e-01 15 85736090 85736134 45 + 1.449 1.581 0.451
ENSG00000170776 E069 33.0471945 0.0014932920 7.996017e-01 8.961371e-01 15 85740222 85740272 51 + 1.428 1.555 0.436
ENSG00000170776 E070 3.9676841 0.1779411288 1.323728e-01 3.355509e-01 15 85740273 85740562 290 + 0.800 0.573 -0.950
ENSG00000170776 E071 96.0814681 0.0236438940 8.812368e-01 9.419506e-01 15 85741046 85741495 450 + 1.884 2.003 0.399
ENSG00000170776 E072 75.6346257 0.0005797329 2.108708e-01 4.428072e-01 15 85743492 85743825 334 + 1.749 1.917 0.565
ENSG00000170776 E073 586.6996910 1.4474498740 3.423306e-01 5.800625e-01 15 85744628 85747603 2976 + 2.447 2.850 1.340
ENSG00000170776 E074 101.2790049 0.4641715865 1.019873e-01 2.853530e-01 15 85747604 85747809 206 + 1.612 2.105 1.662
ENSG00000170776 E075 280.3786672 1.0961947143 2.394483e-01 4.759690e-01 15 85747810 85748751 942 + 2.060 2.543 1.613
ENSG00000170776 E076 125.4828622 0.1280047921 4.768035e-03 3.336859e-02 15 85748752 85749358 607 + 1.660 2.205 1.831