ENSG00000170522

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302274 ENSG00000170522 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOVL6 protein_coding protein_coding 6.313488 2.943727 9.670267 0.8847291 0.8076138 1.71251 1.8025332 0.50095800 3.8843910 0.22848451 0.1873590 2.9301211 0.23575417 0.14033333 0.40473333 0.264400000 0.049237033 0.003755668 FALSE TRUE
ENST00000394607 ENSG00000170522 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOVL6 protein_coding protein_coding 6.313488 2.943727 9.670267 0.8847291 0.8076138 1.71251 1.6628836 0.69470848 2.1273281 0.06389937 0.1927944 1.6007099 0.27971667 0.29376667 0.22613333 -0.067633333 0.910877145 0.003755668 FALSE TRUE
ENST00000503885 ENSG00000170522 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOVL6 protein_coding protein_coding 6.313488 2.943727 9.670267 0.8847291 0.8076138 1.71251 0.7112491 0.27712061 0.6877058 0.27712061 0.6877058 1.2809620 0.09190417 0.07166667 0.06973333 -0.001933333 0.933434893 0.003755668 FALSE FALSE
ENST00000506625 ENSG00000170522 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOVL6 protein_coding protein_coding 6.313488 2.943727 9.670267 0.8847291 0.8076138 1.71251 0.6116096 0.09627397 1.6362385 0.09627397 0.5984282 3.9533132 0.08277500 0.02540000 0.16306667 0.137666667 0.230779456 0.003755668 FALSE FALSE
ENST00000513003 ENSG00000170522 HEK293_OSMI2_6hA HEK293_TMG_6hB ELOVL6 protein_coding processed_transcript 6.313488 2.943727 9.670267 0.8847291 0.8076138 1.71251 1.4446334 1.37466625 1.2052886 0.44920329 0.4640619 -0.1882393 0.29880000 0.46880000 0.12053333 -0.348266667 0.003755668 0.003755668   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170522 E001 475.5645089 0.024498633 9.170536e-01 9.607398e-01 4 110045846 110051669 5824 - 2.548 2.615 0.224
ENSG00000170522 E002 24.4564889 0.001791573 3.563919e-01 5.928608e-01 4 110051670 110051693 24 - 1.301 1.287 -0.050
ENSG00000170522 E003 27.1825805 0.001524647 3.292827e-01 5.682837e-01 4 110051694 110051725 32 - 1.346 1.332 -0.050
ENSG00000170522 E004 31.2488107 0.001393464 2.498932e-02 1.121887e-01 4 110051726 110051762 37 - 1.420 1.302 -0.409
ENSG00000170522 E005 35.8481669 0.001039970 2.120697e-03 1.787843e-02 4 110059603 110059644 42 - 1.481 1.303 -0.618
ENSG00000170522 E006 30.5198705 0.001346585 2.964574e-03 2.318738e-02 4 110059645 110059649 5 - 1.413 1.219 -0.678
ENSG00000170522 E007 43.8880691 0.001115096 2.549595e-02 1.137326e-01 4 110059650 110059754 105 - 1.555 1.466 -0.303
ENSG00000170522 E008 0.0000000       4 110059755 110060039 285 -      
ENSG00000170522 E009 0.3206185 0.027442404 1.000000e+00   4 110093106 110093134 29 - 0.112 0.000 -13.022
ENSG00000170522 E010 39.0967588 0.033502722 7.548379e-01 8.695814e-01 4 110105497 110105628 132 - 1.477 1.567 0.310
ENSG00000170522 E011 5.8791304 0.105509846 4.178302e-06 9.860642e-05 4 110197891 110197974 84 - 0.416 1.276 3.475
ENSG00000170522 E012 34.0390944 0.815709031 2.800433e-01 5.201552e-01 4 110198247 110198367 121 - 1.349 1.686 1.157
ENSG00000170522 E013 12.0432789 0.084028945 7.579192e-01 8.713151e-01 4 110198368 110198521 154 - 0.992 1.107 0.420
ENSG00000170522 E014 11.2772880 0.003339204 6.146801e-04 6.707802e-03 4 110198522 110198653 132 - 0.882 1.302 1.525
ENSG00000170522 E015 1.3717497 0.202946929 7.134706e-01   4 110198842 110199099 258 - 0.276 0.390 0.713
ENSG00000170522 E016 0.8156366 0.016782937 2.992266e-01   4 110199100 110199199 100 - 0.159 0.383 1.679