ENSG00000170500

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393437 ENSG00000170500 HEK293_OSMI2_6hA HEK293_TMG_6hB LONRF2 protein_coding protein_coding 2.898738 3.2676 3.302041 0.381681 0.3050797 0.0150809 2.474592 3.2676 1.929524 0.381681 0.8964785 -0.7569373 0.8774833 1 0.5395 -0.4605 0.01206246 0.01206246 FALSE TRUE
ENST00000409647 ENSG00000170500 HEK293_OSMI2_6hA HEK293_TMG_6hB LONRF2 protein_coding protein_coding 2.898738 3.2676 3.302041 0.381681 0.3050797 0.0150809 0.424146 0.0000 1.372517 0.000000 0.5922476 7.1111538 0.1225167 0 0.4605 0.4605 0.01216567 0.01206246 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170500 E001 875.749287 1.295974235 0.28753860 0.52828313 2 100271875 100283541 11667 - 2.726 3.084 1.191
ENSG00000170500 E002 73.808125 0.368130175 0.71258814 0.84339218 2 100283542 100284492 951 - 1.803 1.934 0.440
ENSG00000170500 E003 25.139907 0.133559463 0.24429705 0.48142474 2 100286914 100287063 150 - 1.359 1.467 0.375
ENSG00000170500 E004 28.276918 0.218927411 0.05465262 0.19055315 2 100290258 100290420 163 - 1.525 1.401 -0.426
ENSG00000170500 E005 23.571810 0.217747093 0.03714782 0.14730665 2 100294229 100294387 159 - 1.467 1.299 -0.584
ENSG00000170500 E006 23.421431 0.182901882 0.02468197 0.11122933 2 100295432 100295553 122 - 1.462 1.301 -0.560
ENSG00000170500 E007 22.373379 0.179390154 0.09105448 0.26558709 2 100298836 100298950 115 - 1.388 1.348 -0.136
ENSG00000170500 E008 20.038946 0.155521358 0.03451135 0.14022782 2 100299226 100299319 94 - 1.370 1.270 -0.349
ENSG00000170500 E009 19.694125 0.128224380 0.02847209 0.12271916 2 100299717 100299918 202 - 1.357 1.270 -0.303
ENSG00000170500 E010 22.893608 0.126209541 0.01939038 0.09381581 2 100300644 100300787 144 - 1.424 1.327 -0.337
ENSG00000170500 E011 16.952332 0.103505574 0.06008380 0.20302059 2 100302921 100303043 123 - 1.259 1.251 -0.030
ENSG00000170500 E012 10.447908 0.007912075 0.75515622 0.86976941 2 100309107 100309225 119 - 0.957 1.152 0.713
ENSG00000170500 E013 0.000000       2 100309485 100309505 21 -      
ENSG00000170500 E014 8.497163 0.152642590 0.31030668 0.55077683 2 100321415 100322501 1087 - 0.925 1.035 0.409