ENSG00000170471

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262879 ENSG00000170471 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPB protein_coding protein_coding 12.83024 11.22732 17.10229 3.192044 0.5392955 0.6067351 2.8564225 3.2294625 3.119249 1.9377980 0.5225609 -0.04993785 0.20476250 0.2192000 0.1828667 -0.03633333 9.806772e-01 1.186974e-07 FALSE TRUE
ENST00000397040 ENSG00000170471 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPB protein_coding protein_coding 12.83024 11.22732 17.10229 3.192044 0.5392955 0.6067351 1.6018070 1.3184013 4.556902 0.6636442 0.4576459 1.78152481 0.13720417 0.1752000 0.2679000 0.09270000 8.309230e-01 1.186974e-07 FALSE TRUE
ENST00000397042 ENSG00000170471 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPB protein_coding protein_coding 12.83024 11.22732 17.10229 3.192044 0.5392955 0.6067351 0.7165967 0.2004422 0.000000 0.2004422 0.0000000 -4.39535230 0.05000833 0.0388000 0.0000000 -0.03880000 8.685686e-01 1.186974e-07 FALSE TRUE
ENST00000438490 ENSG00000170471 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPB protein_coding protein_coding 12.83024 11.22732 17.10229 3.192044 0.5392955 0.6067351 3.9323021 3.4084283 6.425079 1.1030937 0.6186280 0.91262466 0.28682500 0.2930667 0.3747667 0.08170000 5.300879e-01 1.186974e-07 FALSE TRUE
ENST00000632792 ENSG00000170471 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPB protein_coding protein_coding 12.83024 11.22732 17.10229 3.192044 0.5392955 0.6067351 1.1034503 1.5855416 0.000000 0.7828299 0.0000000 -7.31790239 0.11966250 0.1190333 0.0000000 -0.11903333 1.186974e-07 1.186974e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170471 E001 0.4536995 0.1816341483 7.705245e-01   20 38472748 38472808 61 + 0.194 0.136 -0.619
ENSG00000170471 E002 0.7272023 0.0415776645 8.612587e-01   20 38472809 38472815 7 + 0.265 0.240 -0.190
ENSG00000170471 E003 0.7272023 0.0415776645 8.612587e-01   20 38472816 38472817 2 + 0.265 0.240 -0.190
ENSG00000170471 E004 0.7272023 0.0415776645 8.612587e-01   20 38472818 38472829 12 + 0.265 0.240 -0.190
ENSG00000170471 E005 1.1315733 0.2619797664 9.420811e-01   20 38472830 38472842 13 + 0.324 0.381 0.341
ENSG00000170471 E006 1.7396739 0.3900127311 5.417687e-01 7.303416e-01 20 38472843 38472845 3 + 0.504 0.377 -0.667
ENSG00000170471 E007 8.6579681 0.0115070089 5.144108e-01 7.112646e-01 20 38472846 38472899 54 + 0.947 1.040 0.341
ENSG00000170471 E008 9.3405236 0.0037811972 6.012752e-01 7.709933e-01 20 38472900 38472927 28 + 0.987 1.056 0.252
ENSG00000170471 E009 9.9191743 0.0033140937 6.606139e-01 8.103237e-01 20 38472928 38472951 24 + 1.011 1.070 0.214
ENSG00000170471 E010 21.6559421 0.0092988472 3.088157e-01 5.493345e-01 20 38472952 38473069 118 + 1.296 1.407 0.385
ENSG00000170471 E011 61.9298363 0.0006549190 5.293138e-01 7.215656e-01 20 38488403 38488618 216 + 1.800 1.783 -0.055
ENSG00000170471 E012 97.6559260 0.0010596442 1.401439e-05 2.808551e-04 20 38492930 38493132 203 + 2.049 1.891 -0.530
ENSG00000170471 E013 81.8414103 0.0007675199 4.283362e-07 1.352824e-05 20 38497353 38497437 85 + 1.989 1.791 -0.668
ENSG00000170471 E014 64.3256315 0.0078674575 2.357524e-04 3.066262e-03 20 38497438 38497479 42 + 1.896 1.678 -0.737
ENSG00000170471 E015 69.4916574 0.0006861132 2.062966e-04 2.743454e-03 20 38497480 38497516 37 + 1.906 1.753 -0.515
ENSG00000170471 E016 112.9131515 0.0004432356 6.658506e-05 1.063451e-03 20 38499447 38499633 187 + 2.105 1.978 -0.424
ENSG00000170471 E017 0.6188717 0.0291367473 8.058580e-01   20 38499634 38500003 370 + 0.193 0.241 0.405
ENSG00000170471 E018 36.2020906 0.0011462099 9.443242e-02 2.719899e-01 20 38509077 38509084 8 + 1.605 1.517 -0.302
ENSG00000170471 E019 69.2774883 0.0010509991 4.775899e-01 6.854721e-01 20 38509085 38509208 124 + 1.851 1.829 -0.073
ENSG00000170471 E020 39.3923662 0.0024951691 9.145006e-01 9.593549e-01 20 38516192 38516246 55 + 1.590 1.606 0.055
ENSG00000170471 E021 55.3400637 0.0122634056 3.444793e-01 5.820656e-01 20 38516247 38516370 124 + 1.776 1.707 -0.235
ENSG00000170471 E022 72.6589078 0.0015274665 1.138927e-02 6.395461e-02 20 38517506 38517654 149 + 1.906 1.803 -0.345
ENSG00000170471 E023 114.4652191 0.0004120624 1.136800e-04 1.662689e-03 20 38517784 38518000 217 + 2.107 1.987 -0.402
ENSG00000170471 E024 111.1969474 0.0010260365 4.246872e-02 1.611621e-01 20 38521497 38521698 202 + 2.068 2.006 -0.208
ENSG00000170471 E025 93.5728991 0.0010904718 3.299588e-02 1.360591e-01 20 38524778 38524945 168 + 1.998 1.925 -0.243
ENSG00000170471 E026 91.2262887 0.0005091462 4.558350e-02 1.689804e-01 20 38525404 38525514 111 + 1.983 1.919 -0.215
ENSG00000170471 E027 44.1785079 0.0009390595 3.412268e-02 1.391880e-01 20 38525515 38525518 4 + 1.695 1.593 -0.347
ENSG00000170471 E028 96.4535292 0.0004370789 3.231603e-02 1.341465e-01 20 38525895 38526042 148 + 2.013 1.947 -0.223
ENSG00000170471 E029 61.0540726 0.0005980192 3.439401e-01 5.815597e-01 20 38531167 38531231 65 + 1.801 1.770 -0.107
ENSG00000170471 E030 80.8557529 0.0016323092 1.304813e-01 3.325788e-01 20 38532730 38532859 130 + 1.934 1.880 -0.183
ENSG00000170471 E031 0.9772399 0.0174248979 1.686717e-01   20 38534385 38534393 9 + 0.381 0.137 -1.920
ENSG00000170471 E032 30.3536170 0.0028032153 1.669576e-01 3.864806e-01 20 38535074 38535085 12 + 1.529 1.448 -0.277
ENSG00000170471 E033 85.9277936 0.0005092187 7.484961e-01 8.658020e-01 20 38535086 38535207 122 + 1.935 1.934 -0.001
ENSG00000170471 E034 124.1245666 0.0003997146 6.285998e-01 7.896505e-01 20 38539776 38539958 183 + 2.095 2.091 -0.013
ENSG00000170471 E035 113.3683558 0.0004261476 1.898799e-01 4.168033e-01 20 38541041 38541192 152 + 2.066 2.033 -0.110
ENSG00000170471 E036 117.5788522 0.0003371037 6.181990e-01 7.825489e-01 20 38546243 38546430 188 + 2.056 2.085 0.095
ENSG00000170471 E037 1.2333667 0.1971531555 6.959742e-01   20 38546431 38548106 1676 + 0.326 0.392 0.386
ENSG00000170471 E038 94.2307323 0.0007302677 2.532892e-02 1.132106e-01 20 38548689 38548795 107 + 1.928 2.024 0.323
ENSG00000170471 E039 119.0613485 0.0059147674 2.253687e-01 4.597809e-01 20 38551071 38551223 153 + 2.039 2.112 0.245
ENSG00000170471 E040 128.9972377 0.0039443323 2.460949e-01 4.837471e-01 20 38553867 38554076 210 + 2.076 2.148 0.240
ENSG00000170471 E041 114.5334719 0.0014971101 2.860350e-02 1.231532e-01 20 38558295 38558453 159 + 2.017 2.112 0.319
ENSG00000170471 E042 126.7620230 0.0003753871 4.234821e-01 6.462349e-01 20 38562532 38562697 166 + 2.085 2.124 0.129
ENSG00000170471 E043 20.9094142 0.0027247842 6.681913e-01 8.150246e-01 20 38565356 38565358 3 + 1.309 1.353 0.152
ENSG00000170471 E044 117.2790179 0.0003809367 8.384856e-01 9.185712e-01 20 38565359 38565478 120 + 2.060 2.079 0.066
ENSG00000170471 E045 133.0688780 0.0003651500 4.570510e-01 6.710683e-01 20 38567096 38567232 137 + 2.109 2.144 0.118
ENSG00000170471 E046 24.5552428 0.1802168504 1.315929e-01 3.343321e-01 20 38568467 38569887 1421 + 1.520 1.187 -1.160
ENSG00000170471 E047 111.6103056 0.0008348501 4.487306e-03 3.186884e-02 20 38569888 38569996 109 + 1.994 2.107 0.378
ENSG00000170471 E048 95.1148955 0.0012373017 1.973087e-02 9.499550e-02 20 38570769 38570847 79 + 1.930 2.036 0.354
ENSG00000170471 E049 8.4228822 0.0139829987 2.208806e-02 1.028900e-01 20 38573659 38574149 491 + 1.077 0.791 -1.078
ENSG00000170471 E050 132.9573576 0.0056466771 5.037361e-02 1.805697e-01 20 38574150 38574298 149 + 2.069 2.184 0.384
ENSG00000170471 E051 146.3372463 0.0068270182 1.392828e-01 3.464348e-01 20 38574774 38574940 167 + 2.116 2.218 0.342
ENSG00000170471 E052 90.9283118 0.0040681332 6.599627e-02 2.161309e-01 20 38574941 38575034 94 + 1.904 2.012 0.364
ENSG00000170471 E053 262.3486682 0.0003553834 1.575467e-02 8.093855e-02 20 38575035 38575770 736 + 2.382 2.449 0.225
ENSG00000170471 E054 31.5779143 0.0036732042 7.668763e-01 8.767494e-01 20 38575771 38575872 102 + 1.489 1.522 0.114
ENSG00000170471 E055 629.9244414 0.0033988714 4.875976e-04 5.563112e-03 20 38575873 38578859 2987 + 2.746 2.851 0.347