ENSG00000170456

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389082 ENSG00000170456 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND5B protein_coding protein_coding 3.540407 2.341123 4.817477 0.2293476 0.3875388 1.037919 1.5933249 0.755609 1.5935687 0.12398511 0.54024271 1.0666065 0.4217958 0.3181667 0.3159000 -0.002266667 0.9955912145 0.0002800209 FALSE TRUE
ENST00000546299 ENSG00000170456 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND5B protein_coding protein_coding 3.540407 2.341123 4.817477 0.2293476 0.3875388 1.037919 1.1671832 1.358396 1.9465355 0.05560621 0.30177715 0.5158156 0.4017042 0.5883667 0.4004667 -0.187900000 0.2910098902 0.0002800209 FALSE TRUE
MSTRG.7072.4 ENSG00000170456 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND5B protein_coding   3.540407 2.341123 4.817477 0.2293476 0.3875388 1.037919 0.2467157 0.000000 0.4739506 0.00000000 0.05661379 5.5967879 0.0504000 0.0000000 0.1010333 0.101033333 0.0002800209 0.0002800209 FALSE TRUE
MSTRG.7072.6 ENSG00000170456 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND5B protein_coding   3.540407 2.341123 4.817477 0.2293476 0.3875388 1.037919 0.2653772 0.000000 0.4603925 0.00000000 0.46039251 5.5557932 0.0555250 0.0000000 0.1133000 0.113300000 0.9650457285 0.0002800209 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170456 E001 50.2611850 0.682553282 0.2037439986 0.434253082 12 31382226 31383465 1240 - 1.543 1.877 1.131
ENSG00000170456 E002 113.3878187 1.312383103 0.5580595707 0.741896561 12 31383466 31387392 3927 - 1.997 2.094 0.324
ENSG00000170456 E003 1.7739780 0.151105193 0.9931442323 0.998252039 12 31387393 31387406 14 - 0.437 0.454 0.086
ENSG00000170456 E004 6.3476236 0.160063802 0.8192303843 0.907629428 12 31387407 31387532 126 - 0.876 0.786 -0.349
ENSG00000170456 E005 3.8311292 0.335342565 0.3662318407 0.600915028 12 31387533 31387564 32 - 0.741 0.459 -1.262
ENSG00000170456 E006 10.7515540 0.370461469 0.9465333024 0.975572310 12 31387565 31387786 222 - 1.085 0.962 -0.452
ENSG00000170456 E007 11.9466689 0.005380979 0.9404590317 0.972534582 12 31389324 31389498 175 - 1.090 1.120 0.108
ENSG00000170456 E008 8.2316566 0.010147595 0.1880026061 0.414434001 12 31392267 31392393 127 - 0.975 0.851 -0.470
ENSG00000170456 E009 7.9982077 0.005931927 0.0527152993 0.186025066 12 31392614 31392696 83 - 0.994 0.789 -0.782
ENSG00000170456 E010 14.7121064 0.006710061 0.0025512174 0.020664666 12 31398175 31398362 188 - 1.246 0.975 -0.979
ENSG00000170456 E011 15.1051222 0.002787019 0.0102255072 0.059083608 12 31399654 31399772 119 - 1.241 1.035 -0.740
ENSG00000170456 E012 16.2200913 0.017775518 0.0007219466 0.007626945 12 31402498 31402643 146 - 1.294 0.953 -1.227
ENSG00000170456 E013 11.4218706 0.066338985 0.1651437606 0.384133584 12 31409263 31409384 122 - 1.116 0.951 -0.601
ENSG00000170456 E014 10.7936877 0.018550593 0.2853881770 0.525975390 12 31413436 31413564 129 - 1.075 0.995 -0.293
ENSG00000170456 E015 9.3549826 0.007154487 0.3748860098 0.608104332 12 31415367 31415448 82 - 1.013 0.953 -0.225
ENSG00000170456 E016 10.7217066 0.066118371 0.2266259692 0.461336839 12 31423597 31423675 79 - 1.083 0.966 -0.430
ENSG00000170456 E017 8.7774497 0.134110808 0.2007051504 0.430608065 12 31424535 31424568 34 - 1.015 0.862 -0.574
ENSG00000170456 E018 11.9880443 0.019578034 0.0113508309 0.063807751 12 31424569 31424687 119 - 1.162 0.902 -0.954
ENSG00000170456 E019 11.3630628 0.033592169 0.1028607298 0.286893244 12 31426293 31426424 132 - 1.121 0.967 -0.562
ENSG00000170456 E020 0.1779838 0.082166252 0.9010356165   12 31426425 31426751 327 - 0.087 0.000 -7.750
ENSG00000170456 E021 1.4297563 0.037173074 0.0659300010 0.216022199 12 31432375 31433154 780 - 0.222 0.580 2.070
ENSG00000170456 E022 10.5967343 0.133885464 0.2967344082 0.537254546 12 31433155 31433248 94 - 1.082 0.954 -0.468
ENSG00000170456 E023 12.6637792 0.097001794 0.6015890330 0.771174492 12 31442775 31442925 151 - 1.121 1.092 -0.103
ENSG00000170456 E024 18.3947110 0.048326433 0.2440953486 0.481150085 12 31447538 31447769 232 - 1.291 1.207 -0.294
ENSG00000170456 E025 9.5302597 0.051025305 0.0680729179 0.220756338 12 31451702 31451939 238 - 0.871 1.188 1.166
ENSG00000170456 E026 70.3162516 0.012610355 0.3258185584 0.565062500 12 31451940 31452476 537 - 1.786 1.898 0.379
ENSG00000170456 E027 18.5529656 0.036638805 0.9446065728 0.974643173 12 31460194 31460238 45 - 1.241 1.294 0.184
ENSG00000170456 E028 31.6694074 0.023949965 0.4034943416 0.631118471 12 31460239 31460381 143 - 1.443 1.565 0.418
ENSG00000170456 E029 53.0881025 0.001133896 0.0331162992 0.136366947 12 31479589 31480119 531 - 1.657 1.805 0.500
ENSG00000170456 E030 10.7153952 0.004353507 0.2908556264 0.531466499 12 31480120 31480128 9 - 1.074 0.996 -0.285
ENSG00000170456 E031 18.8126522 0.002076148 0.7562330096 0.870364466 12 31480129 31480255 127 - 1.257 1.325 0.237
ENSG00000170456 E032 15.5024882 0.007779011 0.3939884903 0.623514120 12 31495810 31495919 110 - 1.155 1.283 0.451
ENSG00000170456 E033 5.5085020 0.005951734 0.6529294828 0.805340080 12 31499606 31499671 66 - 0.753 0.851 0.386
ENSG00000170456 E034 0.2922838 0.027442404 0.6350107786   12 31500393 31500652 260 - 0.087 0.167 1.076
ENSG00000170456 E035 0.0000000       12 31516351 31516413 63 -      
ENSG00000170456 E036 0.5255656 0.154907938 1.0000000000   12 31540920 31541031 112 - 0.160 0.169 0.092
ENSG00000170456 E037 0.2922838 0.027442404 0.6350107786   12 31590386 31590705 320 - 0.087 0.167 1.076
ENSG00000170456 E038 6.7662102 0.036531311 0.7521854547 0.868059247 12 31590706 31591136 431 - 0.831 0.929 0.375