ENSG00000170234

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307063 ENSG00000170234 HEK293_OSMI2_6hA HEK293_TMG_6hB PWWP2A protein_coding protein_coding 9.551686 5.383818 13.98012 0.927487 0.3725929 1.375029 3.995897 3.0141224 4.607324 0.4572818 0.37540285 0.6105403 0.4701083 0.5637000 0.3287000 -0.23500000 0.002651047 0.002651047 FALSE TRUE
ENST00000456329 ENSG00000170234 HEK293_OSMI2_6hA HEK293_TMG_6hB PWWP2A protein_coding protein_coding 9.551686 5.383818 13.98012 0.927487 0.3725929 1.375029 2.665311 1.3063483 4.534673 0.3045961 0.04824817 1.7876353 0.2684833 0.2379667 0.3247333 0.08676667 0.452102220 0.002651047 FALSE TRUE
MSTRG.27262.4 ENSG00000170234 HEK293_OSMI2_6hA HEK293_TMG_6hB PWWP2A protein_coding   9.551686 5.383818 13.98012 0.927487 0.3725929 1.375029 1.874048 0.5489699 3.177704 0.1485217 0.15746027 2.5116754 0.1670875 0.1018333 0.2281667 0.12633333 0.042264533 0.002651047 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170234 E001 0.7726527 0.7634241246 7.357569e-01   5 160061801 160062093 293 - 0.216 0.290 0.562
ENSG00000170234 E002 0.7249894 0.0271688312 7.776523e-01   5 160063542 160063673 132 - 0.224 0.284 0.454
ENSG00000170234 E003 0.1779838 0.0342364344 1.000000e+00   5 160066548 160066612 65 - 0.088 0.001 -7.338
ENSG00000170234 E004 0.0000000       5 160066780 160066871 92 -      
ENSG00000170234 E005 169.2208433 0.0005386121 6.343033e-07 1.911272e-05 5 160075882 160077843 1962 - 2.243 2.122 -0.406
ENSG00000170234 E006 25.1277663 0.0020398333 3.016903e-04 3.747363e-03 5 160077844 160077932 89 - 1.461 1.187 -0.956
ENSG00000170234 E007 42.1324871 0.0009049375 1.513353e-07 5.381117e-06 5 160077933 160078168 236 - 1.691 1.383 -1.055
ENSG00000170234 E008 11.4024339 0.0873969771 1.508876e-01 3.635822e-01 5 160080651 160080770 120 - 1.135 0.935 -0.732
ENSG00000170234 E009 2.4638531 0.0092483530 5.741649e-01 7.531408e-01 5 160089506 160089610 105 - 0.541 0.455 -0.416
ENSG00000170234 E010 200.1063706 0.0025050326 1.101843e-13 1.360860e-11 5 160091339 160093100 1762 - 2.192 2.416 0.748
ENSG00000170234 E011 195.8908690 0.0005628231 5.634750e-03 3.791395e-02 5 160093101 160093757 657 - 2.289 2.237 -0.173
ENSG00000170234 E012 95.1456312 0.0031608049 6.455991e-01 8.005597e-01 5 160093758 160094065 308 - 1.960 1.953 -0.021
ENSG00000170234 E013 5.0684698 0.0059001631 2.843040e-02 1.225944e-01 5 160108545 160108614 70 - 0.641 0.947 1.220
ENSG00000170234 E014 10.5762164 0.0031068412 1.113789e-02 6.295037e-02 5 160116689 160116986 298 - 0.925 1.199 0.998
ENSG00000170234 E015 9.1967547 0.0034341406 5.528482e-01 7.382801e-01 5 160117751 160117925 175 - 1.000 0.948 -0.192
ENSG00000170234 E016 54.5941948 0.0029899779 1.559932e-03 1.404029e-02 5 160118805 160119450 646 - 1.656 1.839 0.620