ENSG00000170145

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304987 ENSG00000170145 HEK293_OSMI2_6hA HEK293_TMG_6hB SIK2 protein_coding protein_coding 7.200672 7.98374 9.219875 1.170725 0.2632086 0.2074404 5.2947338 6.72783017 5.552054 1.16742320 0.2138951 -0.2766663 0.76081667 0.834633333 0.6041333 -0.23050000 7.895224e-03 8.120065e-12 FALSE TRUE
MSTRG.6293.2 ENSG00000170145 HEK293_OSMI2_6hA HEK293_TMG_6hB SIK2 protein_coding   7.200672 7.98374 9.219875 1.170725 0.2632086 0.2074404 0.7086450 0.01942163 1.590710 0.01942163 0.1734433 5.7656911 0.08345833 0.002066667 0.1728667 0.17080000 8.120065e-12 8.120065e-12 FALSE TRUE
MSTRG.6293.5 ENSG00000170145 HEK293_OSMI2_6hA HEK293_TMG_6hB SIK2 protein_coding   7.200672 7.98374 9.219875 1.170725 0.2632086 0.2074404 0.9399485 0.94494727 1.417682 0.21375697 0.1334077 0.5801816 0.12149167 0.115366667 0.1548000 0.03943333 7.141562e-01 8.120065e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170145 E001 0.4632531 0.0250643210 6.004629e-02   11 111602432 111602448 17 + 0.312 0.000 -10.180
ENSG00000170145 E002 0.9287192 0.0161031810 4.264671e-03   11 111602449 111602462 14 + 0.492 0.000 -13.753
ENSG00000170145 E003 2.8972988 0.0276434677 1.298597e-01 3.316194e-01 11 111602463 111602513 51 + 0.717 0.485 -1.032
ENSG00000170145 E004 36.8104603 0.0063498098 5.530961e-03 3.737851e-02 11 111602514 111602698 185 + 1.671 1.496 -0.596
ENSG00000170145 E005 58.1901881 0.0029423992 7.454980e-05 1.170297e-03 11 111616243 111616359 117 + 1.870 1.679 -0.647
ENSG00000170145 E006 57.5973640 0.0006910710 9.231190e-04 9.286585e-03 11 111620339 111620402 64 + 1.839 1.698 -0.476
ENSG00000170145 E007 74.2664195 0.0006531906 2.388996e-02 1.087394e-01 11 111688001 111688162 162 + 1.920 1.840 -0.269
ENSG00000170145 E008 65.6706497 0.0008169859 4.540875e-03 3.215022e-02 11 111700886 111701010 125 + 1.879 1.765 -0.385
ENSG00000170145 E009 80.7286372 0.0006449198 9.021151e-06 1.920520e-04 11 111701452 111701575 124 + 1.992 1.827 -0.555
ENSG00000170145 E010 114.5828787 0.0003724406 7.267326e-06 1.590001e-04 11 111703203 111703423 221 + 2.130 1.995 -0.453
ENSG00000170145 E011 79.5598733 0.0042062615 9.049546e-02 2.646908e-01 11 111704987 111705139 153 + 1.941 1.867 -0.247
ENSG00000170145 E012 82.5136829 0.0005391979 1.866581e-01 4.126432e-01 11 111712211 111712375 165 + 1.939 1.899 -0.134
ENSG00000170145 E013 0.3503582 0.0382908177 8.912192e-01   11 111718742 111718859 118 + 0.131 0.113 -0.243
ENSG00000170145 E014 103.2792091 0.0004627808 2.732458e-01 5.130965e-01 11 111719775 111720003 229 + 2.033 2.008 -0.087
ENSG00000170145 E015 111.3708951 0.0061009760 1.610137e-02 8.216808e-02 11 111720478 111720762 285 + 2.106 1.996 -0.369
ENSG00000170145 E016 74.1549075 0.0005813498 1.935130e-01 4.214821e-01 11 111720899 111721062 164 + 1.899 1.858 -0.137
ENSG00000170145 E017 59.0059446 0.0043983433 3.622969e-01 5.975609e-01 11 111721830 111721940 111 + 1.740 1.806 0.223
ENSG00000170145 E018 56.4427583 0.0008601617 7.619749e-01 8.737955e-01 11 111722665 111722756 92 + 1.746 1.774 0.093
ENSG00000170145 E019 148.5799757 0.0008201530 4.007640e-01 6.289268e-01 11 111723496 111724110 615 + 2.184 2.171 -0.045
ENSG00000170145 E020 223.8880963 0.0007537982 7.306729e-01 8.545862e-01 11 111724111 111724779 669 + 2.350 2.355 0.015
ENSG00000170145 E021 44.5882355 0.0008168712 5.985898e-01 7.693158e-01 11 111724780 111724782 3 + 1.634 1.675 0.136
ENSG00000170145 E022 491.1994592 0.0007320930 1.896718e-02 9.233641e-02 11 111724783 111726502 1720 + 2.658 2.714 0.185
ENSG00000170145 E023 506.6880280 0.0022965718 7.881049e-08 2.999514e-06 11 111726503 111730256 3754 + 2.621 2.760 0.463
ENSG00000170145 E024 107.1966493 0.0004333003 3.293430e-15 5.159596e-13 11 111730257 111731347 1091 + 1.846 2.143 0.996
ENSG00000170145 E025 1.0870440 0.6066337855 7.554567e-01   11 111731884 111732146 263 + 0.394 0.210 -1.251