ENSG00000170085

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341199 ENSG00000170085 HEK293_OSMI2_6hA HEK293_TMG_6hB SIMC1 protein_coding protein_coding 19.8346 24.14794 16.91277 3.562914 0.7531873 -0.5135316 2.2853944 3.2829044 0.0000000 0.86045145 0.000000 -8.3632168 0.11069583 0.131466667 0.0000000 -0.13146667 2.496745e-14 2.496745e-14 FALSE TRUE
ENST00000429602 ENSG00000170085 HEK293_OSMI2_6hA HEK293_TMG_6hB SIMC1 protein_coding protein_coding 19.8346 24.14794 16.91277 3.562914 0.7531873 -0.5135316 14.5048072 18.5470751 13.4481664 3.20459949 1.315924 -0.4634875 0.73007083 0.761266667 0.7922667 0.03100000 9.015283e-01 2.496745e-14 FALSE TRUE
ENST00000443967 ENSG00000170085 HEK293_OSMI2_6hA HEK293_TMG_6hB SIMC1 protein_coding protein_coding 19.8346 24.14794 16.91277 3.562914 0.7531873 -0.5135316 0.1763533 0.1372791 0.9034824 0.09305301 0.870836 2.6328247 0.01030417 0.005133333 0.0584000 0.05326667 9.438988e-01 2.496745e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000170085 E001 0.0000000       5 176238367 176238381 15 +      
ENSG00000170085 E002 0.0000000       5 176238382 176238423 42 +      
ENSG00000170085 E003 0.0000000       5 176238424 176238424 1 +      
ENSG00000170085 E004 0.7677130 0.0176141889 0.0699101255   5 176238425 176238426 2 + 0.000 0.345 10.951
ENSG00000170085 E005 14.1069685 0.0028904277 0.0058736396 0.039116828 5 176238427 176238452 26 + 0.960 1.239 1.008
ENSG00000170085 E006 14.1069685 0.0028904277 0.0058736396 0.039116828 5 176238453 176238453 1 + 0.960 1.239 1.008
ENSG00000170085 E007 30.3672337 0.0032825395 0.0003364056 0.004103535 5 176238454 176238506 53 + 1.297 1.562 0.915
ENSG00000170085 E008 60.7800516 0.0016982389 0.0002370530 0.003078487 5 176238507 176238637 131 + 1.641 1.832 0.647
ENSG00000170085 E009 0.1426347 0.0321611685 0.2844136072   5 176238656 176239051 396 + 0.154 0.000 -12.424
ENSG00000170085 E010 0.2027342 0.0377371239 0.8005823900   5 176261028 176261149 122 + 0.000 0.095 10.524
ENSG00000170085 E011 0.3641499 0.0328770234 0.6830300391   5 176263417 176263502 86 + 0.155 0.095 -0.808
ENSG00000170085 E012 0.3032425 0.0274424043 0.4021246327   5 176267772 176267899 128 + 0.000 0.172 11.578
ENSG00000170085 E013 0.1723744 0.0423019885 0.8003786562   5 176270230 176270390 161 + 0.000 0.095 10.494
ENSG00000170085 E014 2.0903218 0.0097230231 0.4712255084 0.681051637 5 176270391 176270520 130 + 0.552 0.432 -0.589
ENSG00000170085 E015 175.9959668 0.0005424446 0.0192656343 0.093385124 5 176289654 176290026 373 + 2.271 2.206 -0.216
ENSG00000170085 E016 103.9790982 0.0003958505 0.3319058562 0.570729528 5 176290027 176290209 183 + 2.026 1.994 -0.108
ENSG00000170085 E017 387.7310648 0.0005241802 0.0008451059 0.008655086 5 176290210 176290955 746 + 2.615 2.550 -0.215
ENSG00000170085 E018 116.7597976 0.0003649835 0.0378415954 0.149205750 5 176295030 176295077 48 + 2.100 2.033 -0.225
ENSG00000170085 E019 110.1409040 0.0005064738 0.0295920645 0.126146222 5 176295078 176295149 72 + 2.080 2.007 -0.244
ENSG00000170085 E020 154.6417724 0.0003576023 0.0603000893 0.203498859 5 176295150 176295262 113 + 2.212 2.160 -0.175
ENSG00000170085 E021 1.7128575 0.2687168099 0.7885751459 0.889691852 5 176296123 176296250 128 + 0.363 0.438 0.417
ENSG00000170085 E022 124.0535375 0.0008894059 0.3776139835 0.610323131 5 176296251 176296320 70 + 2.104 2.076 -0.093
ENSG00000170085 E023 1.8523558 0.1773150620 0.3837881711 0.615396789 5 176296321 176296674 354 + 0.556 0.349 -1.077
ENSG00000170085 E024 10.2522398 0.1043937005 0.4260652194 0.648063787 5 176313080 176313484 405 + 0.942 1.084 0.524
ENSG00000170085 E025 210.0967800 0.0002477968 0.2225765748 0.456574919 5 176313691 176313845 155 + 2.328 2.300 -0.095
ENSG00000170085 E026 210.3626045 0.0003145341 0.7687591829 0.877883313 5 176322273 176322425 153 + 2.304 2.314 0.032
ENSG00000170085 E027 4.3757432 0.0065460066 0.3988276195 0.627286625 5 176322426 176322815 390 + 0.787 0.668 -0.488
ENSG00000170085 E028 182.9724524 0.0003861728 0.1349869944 0.339693799 5 176324629 176324757 129 + 2.224 2.268 0.146
ENSG00000170085 E029 201.4463301 0.0003666011 0.0025839090 0.020867756 5 176336720 176336876 157 + 2.239 2.321 0.275
ENSG00000170085 E030 166.6798148 0.0003054099 0.0476782177 0.174234640 5 176337062 176337146 85 + 2.172 2.231 0.197
ENSG00000170085 E031 305.4514553 0.0015629913 0.1161035876 0.309326657 5 176345183 176345566 384 + 2.441 2.483 0.141
ENSG00000170085 E032 85.9996645 0.0216207274 0.7065603248 0.839671698 5 176345567 176345701 135 + 1.891 1.935 0.148
ENSG00000170085 E033 112.7046211 0.0074050428 0.9117516695 0.958040228 5 176345702 176345991 290 + 2.031 2.040 0.030