ENSG00000169926

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307145 ENSG00000169926 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF13 protein_coding protein_coding 10.66302 11.04996 6.142095 0.8115373 0.2085871 -0.8461967 7.2712517 9.843896 4.244620 0.3136494 0.1646463 -1.211664 0.7157833 0.8975667 0.6908333 -0.2067333 4.855109e-01 2.784581e-27 FALSE TRUE
ENST00000558673 ENSG00000169926 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF13 protein_coding processed_transcript 10.66302 11.04996 6.142095 0.8115373 0.2085871 -0.8461967 2.3823299 1.193869 0.000000 0.6449178 0.0000000 -6.911534 0.1633542 0.1012333 0.0000000 -0.1012333 3.934978e-01 2.784581e-27   FALSE
ENST00000560473 ENSG00000169926 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF13 protein_coding protein_coding 10.66302 11.04996 6.142095 0.8115373 0.2085871 -0.8461967 0.9411811 0.000000 1.769546 0.0000000 0.0695740 7.475365 0.1132500 0.0000000 0.2881333 0.2881333 2.784581e-27 2.784581e-27 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169926 E001 14.3304996 0.0021823322 7.302643e-04 7.698534e-03 15 31326835 31327405 571 + 0.866 1.231 1.336
ENSG00000169926 E002 3.9576148 0.0062344480 1.237460e-01 3.216439e-01 15 31327406 31327566 161 + 0.470 0.722 1.130
ENSG00000169926 E003 23.7470316 0.0014734169 3.526874e-01 5.897254e-01 15 31327567 31327789 223 + 1.405 1.332 -0.250
ENSG00000169926 E004 0.0000000       15 31339933 31339987 55 +      
ENSG00000169926 E005 0.0000000       15 31366154 31366554 401 +      
ENSG00000169926 E006 1012.5316701 0.0001392959 9.394186e-15 1.386055e-12 15 31372010 31376523 4514 + 3.006 2.948 -0.191
ENSG00000169926 E007 57.1348671 0.0010388768 5.607466e-02 1.938200e-01 15 31376524 31376563 40 + 1.652 1.749 0.330
ENSG00000169926 E008 320.4654067 0.0001757656 1.916005e-08 8.436137e-07 15 31376564 31377491 928 + 2.386 2.498 0.373
ENSG00000169926 E009 118.7794943 0.0005301294 2.477558e-03 2.017968e-02 15 31377492 31377899 408 + 1.963 2.069 0.358
ENSG00000169926 E010 0.1723744 0.0320487417 1.000000e+00   15 31392843 31393255 413 + 0.000 0.084 8.846
ENSG00000169926 E011 0.0000000       15 31393575 31393575 1 +      
ENSG00000169926 E012 0.0000000       15 31393576 31393691 116 +      
ENSG00000169926 E013 0.1308682 0.0312240788 1.000000e+00   15 31403428 31404729 1302 + 0.000 0.084 8.850
ENSG00000169926 E014 0.0000000       15 31435370 31435665 296 +