ENSG00000169919

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304895 ENSG00000169919 HEK293_OSMI2_6hA HEK293_TMG_6hB GUSB protein_coding protein_coding 55.4339 52.41015 61.05545 0.4089192 1.243576 0.220235 22.217091 20.453907 24.828215 4.5021844 1.2837183 0.27947987 0.39930417 0.39163333 0.4065000 0.0148666667 0.97953980 0.03499974 FALSE  
ENST00000447929 ENSG00000169919 HEK293_OSMI2_6hA HEK293_TMG_6hB GUSB protein_coding nonsense_mediated_decay 55.4339 52.41015 61.05545 0.4089192 1.243576 0.220235 3.046931 2.752137 2.776191 0.3121916 1.6421361 0.01250906 0.05583333 0.05243333 0.0461000 -0.0063333333 0.89277295 0.03499974 FALSE  
ENST00000465785 ENSG00000169919 HEK293_OSMI2_6hA HEK293_TMG_6hB GUSB protein_coding processed_transcript 55.4339 52.41015 61.05545 0.4089192 1.243576 0.220235 2.914339 1.857136 5.205418 1.0919744 1.2397765 1.48195578 0.05007917 0.03563333 0.0846000 0.0489666667 0.73327286 0.03499974 FALSE  
ENST00000466883 ENSG00000169919 HEK293_OSMI2_6hA HEK293_TMG_6hB GUSB protein_coding retained_intron 55.4339 52.41015 61.05545 0.4089192 1.243576 0.220235 5.895449 6.254250 7.210653 2.0612984 0.3468105 0.20498765 0.10731667 0.11876667 0.1184333 -0.0003333333 0.97835058 0.03499974 TRUE  
MSTRG.29947.3 ENSG00000169919 HEK293_OSMI2_6hA HEK293_TMG_6hB GUSB protein_coding   55.4339 52.41015 61.05545 0.4089192 1.243576 0.220235 10.184532 10.188272 8.057041 0.4773456 0.3664130 -0.33821328 0.18547083 0.19433333 0.1318667 -0.0624666667 0.03499974 0.03499974 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169919 E001 0.5587019 0.2484945242 0.579998480   7 65960232 65960406 175 - 0.230 0.117 -1.176
ENSG00000169919 E002 0.1779838 0.0326805834 0.437612397   7 65960407 65960593 187 - 0.128 0.000 -8.547
ENSG00000169919 E003 0.3641499 0.0274424043 0.931973367   7 65960594 65960683 90 - 0.128 0.115 -0.175
ENSG00000169919 E004 0.4950181 0.0228958667 0.639196493   7 65960684 65960687 4 - 0.128 0.206 0.822
ENSG00000169919 E005 5.4517607 0.0052415386 0.510978595 0.70870461 7 65960688 65960697 10 - 0.764 0.849 0.335
ENSG00000169919 E006 5.5826288 0.0055057422 0.423695421 0.64637664 7 65960698 65960700 3 - 0.764 0.867 0.404
ENSG00000169919 E007 634.9356325 0.0008996327 0.685747250 0.82634273 7 65960701 65961063 363 - 2.797 2.803 0.022
ENSG00000169919 E008 4.0399279 0.0065659840 0.923798689 0.96428405 7 65964146 65964322 177 - 0.709 0.694 -0.061
ENSG00000169919 E009 264.6183194 0.0071833690 0.821360710 0.90877045 7 65964323 65964329 7 - 2.428 2.414 -0.047
ENSG00000169919 E010 453.4485327 0.0021703416 0.575163082 0.75378855 7 65964330 65964458 129 - 2.663 2.646 -0.055
ENSG00000169919 E011 499.0464077 0.0002290601 0.084055981 0.25288122 7 65967731 65967907 177 - 2.682 2.709 0.091
ENSG00000169919 E012 2.0895140 0.0095496333 0.243950837 0.48098247 7 65967908 65967908 1 - 0.375 0.572 0.991
ENSG00000169919 E013 281.0887659 0.0038909550 0.279137142 0.51925587 7 65970282 65970366 85 - 2.428 2.465 0.125
ENSG00000169919 E014 1.5279790 0.1143312971 0.032447548 0.13454949 7 65974294 65974294 1 - 0.128 0.568 2.980
ENSG00000169919 E015 263.1142525 0.0008977474 0.792543101 0.89189869 7 65974295 65974356 62 - 2.418 2.423 0.018
ENSG00000169919 E016 204.4945502 0.0020916421 0.617257575 0.78192835 7 65974357 65974401 45 - 2.304 2.318 0.049
ENSG00000169919 E017 121.0370257 0.0008873209 0.071983688 0.22878157 7 65974402 65974403 2 - 2.051 2.112 0.204
ENSG00000169919 E018 169.9900274 0.0027816531 0.099491068 0.28084426 7 65974404 65974441 38 - 2.200 2.258 0.195
ENSG00000169919 E019 42.2489421 0.0888019104 0.974435194 0.98908606 7 65974442 65974502 61 - 1.602 1.662 0.203
ENSG00000169919 E020 29.8978800 0.0986634695 0.895427845 0.94945799 7 65974503 65974525 23 - 1.469 1.508 0.135
ENSG00000169919 E021 351.2444976 0.0002518015 0.065374304 0.21475251 7 65974526 65974704 179 - 2.526 2.561 0.117
ENSG00000169919 E022 113.3889053 0.0555028257 0.804827494 0.89909234 7 65974705 65974918 214 - 2.051 2.061 0.033
ENSG00000169919 E023 133.2873072 0.0109075879 0.426087143 0.64807392 7 65974919 65975011 93 - 2.149 2.107 -0.140
ENSG00000169919 E024 111.6917089 0.0123072853 0.241235920 0.47795907 7 65975012 65975071 60 - 2.087 2.017 -0.232
ENSG00000169919 E025 149.5162390 0.0663201581 0.776274502 0.88248584 7 65975072 65975851 780 - 2.167 2.184 0.056
ENSG00000169919 E026 54.5655672 0.0512765228 0.435801717 0.65558336 7 65975852 65976014 163 - 1.778 1.713 -0.220
ENSG00000169919 E027 402.7667547 0.0002278366 0.002338442 0.01930303 7 65976015 65976202 188 - 2.634 2.577 -0.188
ENSG00000169919 E028 17.4598644 0.0023043512 0.595453085 0.76734039 7 65979386 65979398 13 - 1.234 1.277 0.152
ENSG00000169919 E029 277.5573353 0.0029068970 0.013663470 0.07302277 7 65979399 65979477 79 - 2.485 2.402 -0.275
ENSG00000169919 E030 251.8374915 0.0011230169 0.010392096 0.05983039 7 65979478 65979541 64 - 2.437 2.368 -0.233
ENSG00000169919 E031 239.3736097 0.0044477876 0.527040868 0.71988210 7 65979727 65979833 107 - 2.367 2.389 0.074
ENSG00000169919 E032 184.2447405 0.0040273459 0.462983217 0.67514361 7 65979834 65979911 78 - 2.250 2.277 0.089
ENSG00000169919 E033 310.8256772 0.0001541194 0.239707173 0.47633168 7 65980224 65980409 186 - 2.504 2.479 -0.083
ENSG00000169919 E034 1.3283905 0.2513368537 0.936498187   7 65980410 65980411 2 - 0.370 0.352 -0.106
ENSG00000169919 E035 6.3714402 0.1092866425 0.022935679 0.10573050 7 65980694 65980829 136 - 0.573 1.030 1.822
ENSG00000169919 E036 1.7059629 0.0693764857 0.079054858 0.24293160 7 65981851 65981973 123 - 0.227 0.569 1.980
ENSG00000169919 E037 239.2485493 0.0005125236 0.215685357 0.44826687 7 65981974 65982216 243 - 2.360 2.389 0.098