ENSG00000169905

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367612 ENSG00000169905 HEK293_OSMI2_6hA HEK293_TMG_6hB TOR1AIP2 protein_coding protein_coding 20.26883 13.23752 30.10298 3.696811 2.724085 1.184663 1.914653 1.6794015 2.384986 0.6641839 0.1234449 0.5035052 0.10273750 0.11260000 0.07983333 -0.03276667 7.525995e-01 5.004663e-11 FALSE TRUE
ENST00000482587 ENSG00000169905 HEK293_OSMI2_6hA HEK293_TMG_6hB TOR1AIP2 protein_coding protein_coding 20.26883 13.23752 30.10298 3.696811 2.724085 1.184663 5.219383 4.6581988 5.831136 1.2176545 0.2158211 0.3233829 0.31417917 0.35740000 0.19580000 -0.16160000 2.249752e-04 5.004663e-11 FALSE TRUE
ENST00000495650 ENSG00000169905 HEK293_OSMI2_6hA HEK293_TMG_6hB TOR1AIP2 protein_coding protein_coding 20.26883 13.23752 30.10298 3.696811 2.724085 1.184663 3.809060 1.9552685 6.419435 0.6943196 1.1548065 1.7099654 0.16026667 0.13773333 0.20953333 0.07180000 4.234026e-01 5.004663e-11   FALSE
ENST00000609928 ENSG00000169905 HEK293_OSMI2_6hA HEK293_TMG_6hB TOR1AIP2 protein_coding protein_coding 20.26883 13.23752 30.10298 3.696811 2.724085 1.184663 3.244941 2.4933780 4.306526 0.4478538 1.4307064 0.7859944 0.16214583 0.20583333 0.13643333 -0.06940000 7.139999e-01 5.004663e-11 FALSE TRUE
MSTRG.2675.1 ENSG00000169905 HEK293_OSMI2_6hA HEK293_TMG_6hB TOR1AIP2 protein_coding   20.26883 13.23752 30.10298 3.696811 2.724085 1.184663 1.556008 0.0000000 3.877759 0.0000000 0.5242330 8.6027950 0.05397083 0.00000000 0.13376667 0.13376667 5.004663e-11 5.004663e-11 FALSE TRUE
MSTRG.2675.3 ENSG00000169905 HEK293_OSMI2_6hA HEK293_TMG_6hB TOR1AIP2 protein_coding   20.26883 13.23752 30.10298 3.696811 2.724085 1.184663 1.492594 0.1979809 3.830137 0.1119600 0.4682418 4.2066350 0.05673333 0.01976667 0.12903333 0.10926667 1.444874e-01 5.004663e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169905 E001 0.5767453 0.021590025 1.650836e-01   1 179820392 179820449 58 - 0.086 0.385 2.713
ENSG00000169905 E002 2.7315588 0.008396052 9.366096e-01 9.705100e-01 1 179836182 179836209 28 - 0.502 0.638 0.616
ENSG00000169905 E003 3.0462079 0.015810663 4.453827e-01 6.623563e-01 1 179836210 179836245 36 - 0.584 0.587 0.012
ENSG00000169905 E004 3.5703685 0.009414745 8.941393e-02 2.627083e-01 1 179836246 179836299 54 - 0.673 0.530 -0.635
ENSG00000169905 E005 3.7854664 0.010972283 9.166526e-01 9.604910e-01 1 179836300 179836403 104 - 0.608 0.724 0.493
ENSG00000169905 E006 0.1614157 0.032958871 7.099804e-01   1 179839967 179839975 9 - 0.086 0.000 -8.002
ENSG00000169905 E007 492.5966009 1.625516824 3.428407e-01 5.805259e-01 1 179839976 179844099 4124 - 2.448 2.926 1.593
ENSG00000169905 E008 29.7984890 0.484202998 4.364719e-01 6.561182e-01 1 179844100 179844133 34 - 1.377 1.597 0.758
ENSG00000169905 E009 273.9809878 1.562464746 7.139179e-01 8.442992e-01 1 179844134 179846043 1910 - 2.375 2.473 0.328
ENSG00000169905 E010 45.4038723 0.740011403 9.078867e-01 9.560775e-01 1 179846044 179846106 63 - 1.645 1.618 -0.092
ENSG00000169905 E011 152.5075699 1.394396020 8.786691e-01 9.406022e-01 1 179846107 179846828 722 - 2.173 2.116 -0.190
ENSG00000169905 E012 52.0229729 0.001937108 1.848913e-07 6.432862e-06 1 179847535 179847636 102 - 1.739 1.613 -0.428
ENSG00000169905 E013 172.1744040 0.034468502 1.274334e-06 3.504069e-05 1 179850845 179851363 519 - 2.281 1.998 -0.946
ENSG00000169905 E014 91.9672913 0.034824339 2.886514e-07 9.522076e-06 1 179852632 179852811 180 - 2.023 1.673 -1.180
ENSG00000169905 E015 24.1072080 0.029868160 5.164178e-05 8.553553e-04 1 179856058 179856170 113 - 1.447 1.142 -1.068
ENSG00000169905 E016 0.7970432 0.017267182 3.499467e-01   1 179857822 179857832 11 - 0.272 0.170 -0.868
ENSG00000169905 E017 0.8571428 0.017267182 1.000000e+00   1 179857833 179857841 9 - 0.219 0.291 0.548
ENSG00000169905 E018 6.7446143 0.004195138 1.454422e-02 7.641677e-02 1 179857842 179857986 145 - 0.673 1.112 1.687
ENSG00000169905 E019 781.4157630 0.047088210 1.217947e-01 3.187134e-01 1 179859030 179865064 6035 - 2.733 3.053 1.064
ENSG00000169905 E020 160.7054570 0.016774248 7.310147e-01 8.548051e-01 1 179865065 179865435 371 - 2.122 2.277 0.516
ENSG00000169905 E021 177.5239496 0.020985491 8.661454e-03 5.230900e-02 1 179865436 179865678 243 - 2.225 2.213 -0.040
ENSG00000169905 E022 143.7168116 0.025014544 1.041020e-02 5.989806e-02 1 179865679 179865854 176 - 2.136 2.118 -0.061
ENSG00000169905 E023 13.0463663 0.050739659 8.426078e-01 9.209127e-01 1 179867527 179869196 1670 - 1.065 1.224 0.569
ENSG00000169905 E024 6.3782345 0.098840091 8.250752e-02 2.497447e-01 1 179873706 179876177 2472 - 0.893 0.686 -0.823
ENSG00000169905 E025 110.2062213 0.021863468 5.394202e-02 1.889416e-01 1 179877239 179877373 135 - 2.003 2.041 0.129
ENSG00000169905 E026 62.5364812 0.009987790 3.355910e-01 5.740870e-01 1 179877693 179877803 111 - 1.731 1.848 0.393