ENSG00000169783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355300 ENSG00000169783 HEK293_OSMI2_6hA HEK293_TMG_6hB LINGO1 protein_coding protein_coding 13.86499 17.32442 6.697541 1.905337 0.6266694 -1.369784 3.746956 4.392842 0.9474498 0.6701620 0.3426262 -2.2011662 0.25475833 0.2513667 0.1343667 -0.11700000 0.49999625 0.03847083 FALSE TRUE
ENST00000557798 ENSG00000169783 HEK293_OSMI2_6hA HEK293_TMG_6hB LINGO1 protein_coding protein_coding 13.86499 17.32442 6.697541 1.905337 0.6266694 -1.369784 3.861255 4.027146 2.6210526 0.2425591 0.1975125 -0.6176956 0.29752500 0.2359333 0.3944000 0.15846667 0.03847083 0.03847083 FALSE TRUE
ENST00000561030 ENSG00000169783 HEK293_OSMI2_6hA HEK293_TMG_6hB LINGO1 protein_coding protein_coding 13.86499 17.32442 6.697541 1.905337 0.6266694 -1.369784 4.623674 6.700297 2.7129427 0.8883493 0.3284071 -1.3012100 0.33540000 0.3847000 0.4028667 0.01816667 0.93346535 0.03847083 FALSE TRUE
MSTRG.11288.3 ENSG00000169783 HEK293_OSMI2_6hA HEK293_TMG_6hB LINGO1 protein_coding   13.86499 17.32442 6.697541 1.905337 0.6266694 -1.369784 1.124341 1.661043 0.2333116 0.1995442 0.1019705 -2.7798715 0.07667917 0.0964000 0.0384000 -0.05800000 0.34617423 0.03847083 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169783 E001 38.9989753 0.0012610362 0.173996624 0.39586604 15 77613027 77613669 643 - 1.393 1.500 0.371
ENSG00000169783 E002 70.3806348 0.0083804071 0.702837340 0.83736457 15 77613670 77614018 349 - 1.752 1.723 -0.097
ENSG00000169783 E003 300.8602423 0.0012347564 0.254328586 0.49278417 15 77614019 77614943 925 - 2.329 2.361 0.108
ENSG00000169783 E004 210.1107963 0.0003624247 0.066818310 0.21790275 15 77614944 77615352 409 - 2.246 2.194 -0.174
ENSG00000169783 E005 115.5043551 0.0004996701 0.200017552 0.42970111 15 77615353 77615511 159 - 1.988 1.937 -0.170
ENSG00000169783 E006 48.0790930 0.0013268968 0.095238765 0.27339120 15 77615512 77615512 1 - 1.658 1.554 -0.353
ENSG00000169783 E007 79.3411115 0.0006030384 0.029027630 0.12443040 15 77615513 77615598 86 - 1.871 1.767 -0.351
ENSG00000169783 E008 52.9958151 0.0007650948 0.131176996 0.33366879 15 77615599 77615641 43 - 1.685 1.597 -0.300
ENSG00000169783 E009 46.7805661 0.0008897901 0.175090404 0.39726880 15 77615642 77615672 31 - 1.630 1.546 -0.287
ENSG00000169783 E010 45.6056739 0.0007926979 0.537990664 0.72763407 15 77615673 77615721 49 - 1.513 1.558 0.153
ENSG00000169783 E011 39.6819010 0.0010053701 0.243109932 0.48014395 15 77615722 77615781 60 - 1.417 1.508 0.313
ENSG00000169783 E012 31.3848146 0.0072874387 0.586202599 0.76107418 15 77615782 77615832 51 - 1.352 1.408 0.194
ENSG00000169783 E013 23.9916667 0.0037232148 0.064537409 0.21285976 15 77615833 77615853 21 - 1.121 1.316 0.692
ENSG00000169783 E014 25.2998482 0.0025617772 0.055408090 0.19225665 15 77615854 77615876 23 - 1.144 1.338 0.684
ENSG00000169783 E015 25.4201675 0.0015027989 0.056080321 0.19383173 15 77615877 77615900 24 - 1.144 1.333 0.668
ENSG00000169783 E016 24.6787503 0.0014885093 0.210580110 0.44250329 15 77632310 77632912 603 - 1.187 1.309 0.433
ENSG00000169783 E017 0.0000000       15 77634276 77634353 78 -      
ENSG00000169783 E018 5.5884920 0.0075538183 0.012648703 0.06903554 15 77677089 77677106 18 - 0.235 0.782 2.813
ENSG00000169783 E019 4.6005489 0.0057570577 0.037172355 0.14736048 15 77677107 77677108 2 - 0.235 0.703 2.495
ENSG00000169783 E020 8.5098932 0.0276955847 0.579663704 0.75697050 15 77677109 77677155 47 - 0.780 0.889 0.422
ENSG00000169783 E021 7.3113411 0.6530206423 0.543744805 0.73174488 15 77677156 77677174 19 - 0.786 0.814 0.108
ENSG00000169783 E022 16.1496752 0.5960667000 0.486039995 0.69125571 15 77690720 77690901 182 - 1.126 1.111 -0.055
ENSG00000169783 E023 0.1308682 0.6506881943 0.608933607   15 77695971 77696148 178 - 0.000 0.057 7.865
ENSG00000169783 E024 0.5059767 0.0284294588 1.000000000   15 77696391 77696495 105 - 0.000 0.157 10.641
ENSG00000169783 E025 0.0000000       15 77707394 77707507 114 -      
ENSG00000169783 E026 5.7118789 0.0279898202 0.256251725 0.49503386 15 77715730 77715948 219 - 0.872 0.700 -0.683
ENSG00000169783 E027 0.0000000       15 77720617 77720751 135 -      
ENSG00000169783 E028 11.2227347 0.0036113506 0.006743428 0.04343761 15 77734992 77735053 62 - 0.588 1.023 1.732
ENSG00000169783 E029 0.1723744 0.9288158300 0.596995989   15 77786869 77787014 146 - 0.000 0.060 7.781
ENSG00000169783 E030 10.1282167 0.5736509982 0.753189837 0.86865756 15 77795939 77796053 115 - 0.834 0.947 0.430
ENSG00000169783 E031 5.0697191 0.0097346278 0.544105254 0.73201783 15 77819271 77819713 443 - 0.588 0.714 0.539
ENSG00000169783 E032 1.0352465 0.5126310069 0.268058693   15 77819934 77820033 100 - 0.391 0.224 -1.113
ENSG00000169783 E033 1.5577914 1.3464252990 0.844273814 0.92172843 15 77820034 77820257 224 - 0.401 0.319 -0.482
ENSG00000169783 E034 0.3032425 0.1441407003 1.000000000   15 77820258 77820332 75 - 0.000 0.110 9.538
ENSG00000169783 E035 0.0000000       15 77820779 77820786 8 -      
ENSG00000169783 E036 0.0000000       15 77820787 77820842 56 -      
ENSG00000169783 E037 0.0000000       15 77820843 77820900 58 -