ENSG00000169760

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361589 ENSG00000169760 HEK293_OSMI2_6hA HEK293_TMG_6hB NLGN1 protein_coding protein_coding 1.561017 0.2789765 2.920787 0.04918734 0.08494044 3.342264 0.05964304 0.01061048 0.0000000 0.01061048 0.00000000 -1.0433782 0.09687083 0.04590000 0.00000000 -0.04590000 0.50743722 0.03128469 FALSE TRUE
ENST00000413821 ENSG00000169760 HEK293_OSMI2_6hA HEK293_TMG_6hB NLGN1 protein_coding protein_coding 1.561017 0.2789765 2.920787 0.04918734 0.08494044 3.342264 0.39337871 0.00000000 0.8323288 0.00000000 0.15360577 6.3963116 0.13596250 0.00000000 0.28803333 0.28803333 0.03128469 0.03128469   FALSE
ENST00000423427 ENSG00000169760 HEK293_OSMI2_6hA HEK293_TMG_6hB NLGN1 protein_coding protein_coding 1.561017 0.2789765 2.920787 0.04918734 0.08494044 3.342264 0.09685341 0.10377907 0.1151823 0.03013404 0.07686825 0.1377957 0.19690000 0.36460000 0.03803333 -0.32656667 0.07700543 0.03128469   FALSE
ENST00000457714 ENSG00000169760 HEK293_OSMI2_6hA HEK293_TMG_6hB NLGN1 protein_coding protein_coding 1.561017 0.2789765 2.920787 0.04918734 0.08494044 3.342264 0.33249810 0.10270952 0.6706588 0.02534166 0.09706700 2.5943224 0.23410833 0.37423333 0.22910000 -0.14513333 0.72359523 0.03128469 FALSE TRUE
ENST00000469564 ENSG00000169760 HEK293_OSMI2_6hA HEK293_TMG_6hB NLGN1 protein_coding processed_transcript 1.561017 0.2789765 2.920787 0.04918734 0.08494044 3.342264 0.03608327 0.01832781 0.0000000 0.01832781 0.00000000 -1.5022189 0.02097917 0.08026667 0.00000000 -0.08026667 0.42125219 0.03128469 FALSE FALSE
MSTRG.24084.3 ENSG00000169760 HEK293_OSMI2_6hA HEK293_TMG_6hB NLGN1 protein_coding   1.561017 0.2789765 2.920787 0.04918734 0.08494044 3.342264 0.06901285 0.00000000 0.1784147 0.00000000 0.06387403 4.2358394 0.03383750 0.00000000 0.06026667 0.06026667 0.64383038 0.03128469 FALSE TRUE
MSTRG.24084.8 ENSG00000169760 HEK293_OSMI2_6hA HEK293_TMG_6hB NLGN1 protein_coding   1.561017 0.2789765 2.920787 0.04918734 0.08494044 3.342264 0.50833154 0.02335049 0.9580360 0.02335049 0.09506046 4.8592809 0.20841667 0.06186667 0.32760000 0.26573333 0.11950622 0.03128469 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169760 E001 1.6388352 0.0157455905 0.0006740213 0.007215805 3 173396284 173396695 412 + 0.177 0.776 3.303
ENSG00000169760 E002 1.3779227 0.3526027421 1.0000000000   3 173397744 173397777 34 + 0.279 0.267 -0.089
ENSG00000169760 E003 1.2352881 0.4785429817 0.8248181458   3 173397778 173397779 2 + 0.251 0.268 0.123
ENSG00000169760 E004 1.2352881 0.4785429817 0.8248181458   3 173397780 173397781 2 + 0.251 0.268 0.123
ENSG00000169760 E005 5.8876092 0.0304795418 0.9379086668 0.971228670 3 173397782 173398063 282 + 0.692 0.711 0.079
ENSG00000169760 E006 0.4349185 0.0217681645 0.3415991390   3 173398448 173398487 40 + 0.097 0.261 1.715
ENSG00000169760 E007 0.1426347 0.0338463966 0.8521922986   3 173399584 173399871 288 + 0.051 0.000 -10.518
ENSG00000169760 E008 0.1308682 0.0326491905 0.0528222240   3 173435010 173435078 69 + 0.000 0.261 13.716
ENSG00000169760 E009 0.1308682 0.0326491905 0.0528222240   3 173584555 173584919 365 + 0.000 0.261 13.716
ENSG00000169760 E010 0.1308682 0.0326491905 0.0528222240   3 173584920 173585034 115 + 0.000 0.261 13.716
ENSG00000169760 E011 11.2877870 0.0030791113 0.1854476976 0.411150217 3 173604279 173604637 359 + 0.963 0.775 -0.722
ENSG00000169760 E012 13.5520516 0.0047052715 0.8242867127 0.910453916 3 173604638 173605091 454 + 1.023 1.004 -0.072
ENSG00000169760 E013 0.0000000       3 173605534 173605593 60 +      
ENSG00000169760 E014 0.6434498 0.0196645500 0.8341387733   3 173800293 173800352 60 + 0.177 0.000 -12.324
ENSG00000169760 E015 8.1299016 0.0037412531 0.2057881942 0.436795451 3 173807680 173807832 153 + 0.840 0.634 -0.839
ENSG00000169760 E016 0.0000000       3 174136435 174136447 13 +      
ENSG00000169760 E017 0.0000000       3 174136448 174136461 14 +      
ENSG00000169760 E018 0.0000000       3 174136462 174136580 119 +      
ENSG00000169760 E019 0.0000000       3 174180788 174180848 61 +      
ENSG00000169760 E020 0.0000000       3 174202701 174202814 114 +      
ENSG00000169760 E021 8.9220729 0.0038299354 0.1459498348 0.356310037 3 174275315 174275500 186 + 0.870 0.634 -0.956
ENSG00000169760 E022 4.0284601 0.0063677018 0.3945864242 0.624019395 3 174275501 174275527 27 + 0.591 0.424 -0.807
ENSG00000169760 E023 17.4690708 0.0070922510 0.1878534696 0.414218157 3 174278861 174279296 436 + 1.126 0.967 -0.579
ENSG00000169760 E024 16.8716213 0.0023801381 0.8173286615 0.906569567 3 174279297 174279650 354 + 1.095 1.127 0.115
ENSG00000169760 E025 26.3414265 0.0050606870 0.8216549774 0.908922167 3 174280481 174281061 581 + 1.281 1.265 -0.056
ENSG00000169760 E026 70.2654110 0.0009208614 0.0148469530 0.077489523 3 174281062 174288514 7453 + 1.675 1.794 0.402
ENSG00000169760 E027 15.9924413 0.0024574836 0.0836945674 0.252189327 3 174288515 174294372 5858 + 1.100 0.882 -0.807