ENSG00000169718

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000538833 ENSG00000169718 HEK293_OSMI2_6hA HEK293_TMG_6hB DUS1L protein_coding protein_coding 290.547 454.8251 145.0335 72.54595 3.159556 -1.648858 30.57939 48.76993 5.450015 13.277534 0.451167 -3.159311 0.08320417 0.10280000 0.03760000 -0.065200000 1.552479e-03 1.697377e-17 FALSE  
ENST00000542088 ENSG00000169718 HEK293_OSMI2_6hA HEK293_TMG_6hB DUS1L protein_coding protein_coding 290.547 454.8251 145.0335 72.54595 3.159556 -1.648858 17.87471 28.35192 11.355051 6.108665 1.336303 -1.319351 0.06649583 0.06913333 0.07876667 0.009633333 9.012077e-01 1.697377e-17 FALSE  
ENST00000579854 ENSG00000169718 HEK293_OSMI2_6hA HEK293_TMG_6hB DUS1L protein_coding retained_intron 290.547 454.8251 145.0335 72.54595 3.159556 -1.648858 44.34504 62.42922 16.603902 8.455644 4.200068 -1.910062 0.14042083 0.13860000 0.11350000 -0.025100000 8.150536e-01 1.697377e-17 FALSE  
ENST00000582529 ENSG00000169718 HEK293_OSMI2_6hA HEK293_TMG_6hB DUS1L protein_coding protein_coding 290.547 454.8251 145.0335 72.54595 3.159556 -1.648858 14.64995 27.15160 0.000000 8.401587 0.000000 -11.407353 0.05484583 0.05650000 0.00000000 -0.056500000 1.697377e-17 1.697377e-17 FALSE  
MSTRG.15330.2 ENSG00000169718 HEK293_OSMI2_6hA HEK293_TMG_6hB DUS1L protein_coding   290.547 454.8251 145.0335 72.54595 3.159556 -1.648858 83.16740 129.52951 42.192274 37.038039 1.820619 -1.618000 0.27767500 0.27133333 0.29096667 0.019633333 9.452787e-01 1.697377e-17 FALSE  
MSTRG.15330.22 ENSG00000169718 HEK293_OSMI2_6hA HEK293_TMG_6hB DUS1L protein_coding   290.547 454.8251 145.0335 72.54595 3.159556 -1.648858 59.08034 104.92329 43.002037 10.469973 1.464472 -1.286660 0.21709583 0.23626667 0.29636667 0.060100000 4.011533e-01 1.697377e-17 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169718 E001 8.355424 2.061786e-01 2.618655e-01 0.500971266 17 82057506 82057871 366 - 1.135 0.784 -1.317
ENSG00000169718 E002 15.978586 2.957030e-03 5.654884e-01 0.747032490 17 82057872 82057879 8 - 1.098 1.146 0.175
ENSG00000169718 E003 23.557301 1.509820e-03 3.247492e-02 0.134630117 17 82057880 82057881 2 - 1.140 1.332 0.677
ENSG00000169718 E004 39.085998 9.757009e-04 9.284744e-03 0.055025759 17 82057882 82057895 14 - 1.357 1.541 0.634
ENSG00000169718 E005 40.466613 9.139252e-04 1.839147e-02 0.090335724 17 82057896 82057899 4 - 1.392 1.553 0.553
ENSG00000169718 E006 106.280518 3.553307e-03 8.162676e-01 0.905972368 17 82057900 82057900 1 - 1.936 1.940 0.014
ENSG00000169718 E007 174.008804 7.170519e-03 2.487238e-01 0.486480757 17 82057901 82057904 4 - 2.202 2.133 -0.230
ENSG00000169718 E008 256.393149 2.450849e-03 9.280533e-01 0.966035292 17 82057905 82057913 9 - 2.327 2.313 -0.048
ENSG00000169718 E009 726.852638 1.779343e-03 7.337840e-01 0.856496615 17 82057914 82058015 102 - 2.769 2.766 -0.010
ENSG00000169718 E010 1134.085329 7.887433e-04 2.086187e-02 0.098892522 17 82058016 82058091 76 - 2.936 2.966 0.099
ENSG00000169718 E011 1594.735268 9.539556e-04 2.477196e-02 0.111524543 17 82058092 82058254 163 - 3.085 3.112 0.090
ENSG00000169718 E012 1247.293634 8.214080e-04 1.092943e-01 0.297948299 17 82058341 82058408 68 - 2.989 3.003 0.048
ENSG00000169718 E013 776.236082 5.747941e-04 1.765788e-01 0.399173831 17 82058409 82058416 8 - 2.828 2.786 -0.138
ENSG00000169718 E014 172.000893 9.683598e-02 2.799514e-01 0.520047039 17 82058417 82058486 70 - 2.272 2.101 -0.573
ENSG00000169718 E015 380.584917 8.887078e-02 2.672061e-01 0.506810016 17 82058487 82058780 294 - 2.612 2.446 -0.553
ENSG00000169718 E016 1218.268912 8.315483e-05 4.430360e-01 0.660764231 17 82058781 82058818 38 - 3.011 2.989 -0.072
ENSG00000169718 E017 375.202341 1.045647e-01 5.818076e-02 0.198679302 17 82058819 82059947 1129 - 2.696 2.401 -0.985
ENSG00000169718 E018 2046.947574 5.662046e-05 3.120001e-02 0.130926870 17 82059948 82060093 146 - 3.211 3.221 0.031
ENSG00000169718 E019 83.786424 9.199929e-02 3.003189e-02 0.127445282 17 82060094 82060157 64 - 2.079 1.741 -1.139
ENSG00000169718 E020 240.273181 8.451501e-02 1.855054e-02 0.090894364 17 82060158 82060700 543 - 2.537 2.191 -1.153
ENSG00000169718 E021 1366.215101 9.300961e-05 4.912709e-04 0.005594387 17 82060701 82060780 80 - 3.018 3.050 0.105
ENSG00000169718 E022 726.414157 1.289500e-04 6.807928e-01 0.823186320 17 82060781 82060783 3 - 2.773 2.767 -0.018
ENSG00000169718 E023 7.791172 1.312746e-02 1.308917e-01 0.333200557 17 82060784 82060860 77 - 1.026 0.813 -0.803
ENSG00000169718 E024 21.074227 1.906470e-03 2.757784e-01 0.515867145 17 82060861 82060864 4 - 1.345 1.240 -0.366
ENSG00000169718 E025 787.199740 1.160936e-04 3.130191e-01 0.553310342 17 82060865 82060876 12 - 2.800 2.804 0.014
ENSG00000169718 E026 1475.338125 7.265750e-05 1.157348e-03 0.011103567 17 82060877 82060961 85 - 3.055 3.082 0.089
ENSG00000169718 E027 23.257034 5.217092e-02 9.758489e-03 0.057082388 17 82060962 82061208 247 - 1.555 1.189 -1.272
ENSG00000169718 E028 1313.619199 2.467108e-03 7.032498e-02 0.225399636 17 82061209 82061257 49 - 2.997 3.028 0.103
ENSG00000169718 E029 1658.489315 5.252390e-04 1.460737e-04 0.002051326 17 82061258 82061351 94 - 3.090 3.133 0.145
ENSG00000169718 E030 903.676290 4.874556e-04 1.235025e-04 0.001781008 17 82061352 82061353 2 - 2.817 2.874 0.192
ENSG00000169718 E031 52.272366 1.488398e-01 6.305386e-02 0.209547371 17 82061354 82061556 203 - 1.878 1.540 -1.145
ENSG00000169718 E032 32.705445 4.397255e-02 6.427960e-02 0.212306341 17 82061557 82061617 61 - 1.621 1.375 -0.842
ENSG00000169718 E033 1681.942457 5.826773e-04 2.581783e-04 0.003305285 17 82061618 82061717 100 - 3.097 3.139 0.141
ENSG00000169718 E034 801.833370 4.811479e-04 9.597070e-01 0.981742451 17 82061718 82061721 4 - 2.822 2.809 -0.044
ENSG00000169718 E035 1658.391893 1.700893e-03 6.812922e-01 0.823463460 17 82061901 82061983 83 - 3.127 3.122 -0.015
ENSG00000169718 E036 1258.211242 1.238610e-03 1.060576e-01 0.292448336 17 82062861 82062881 21 - 3.041 2.993 -0.159
ENSG00000169718 E037 1942.007574 1.210523e-03 9.266092e-03 0.054965346 17 82062882 82062973 92 - 3.242 3.178 -0.211
ENSG00000169718 E038 55.016235 1.202509e-01 1.457422e-02 0.076515231 17 82062974 82063467 494 - 1.952 1.530 -1.428
ENSG00000169718 E039 1358.592508 1.818850e-03 3.756511e-03 0.027777670 17 82063468 82063518 51 - 3.100 3.019 -0.271
ENSG00000169718 E040 1598.706708 5.722346e-04 5.117399e-03 0.035230017 17 82064126 82064201 76 - 3.153 3.096 -0.191
ENSG00000169718 E041 1156.059469 9.164298e-04 3.956850e-01 0.624984094 17 82064202 82064234 33 - 2.991 2.961 -0.101
ENSG00000169718 E042 21.227664 6.248683e-03 2.540016e-03 0.020591617 17 82064235 82064296 62 - 1.465 1.184 -0.979
ENSG00000169718 E043 1565.438228 1.072676e-03 6.013426e-01 0.771033251 17 82064823 82065069 247 - 3.102 3.098 -0.015
ENSG00000169718 E044 19.062385 1.030543e-02 9.023168e-01 0.953037564 17 82065070 82065485 416 - 1.231 1.200 -0.112
ENSG00000169718 E045 4.474738 2.374270e-02 4.363737e-01 0.656057464 17 82065486 82065545 60 - 0.552 0.677 0.549
ENSG00000169718 E046 226.500761 2.349557e-02 8.884329e-05 0.001353637 17 82065613 82065996 384 - 1.991 2.307 1.057
ENSG00000169718 E047 1.591923 2.181687e-01 1.319281e-01 0.334849296 17 82065997 82066178 182 - 0.629 0.254 -2.040
ENSG00000169718 E048 6.350564 4.954807e-03 9.334667e-01 0.968884981 17 82066179 82066340 162 - 0.787 0.792 0.019
ENSG00000169718 E049 4.086288 2.514064e-02 8.196032e-01 0.907871940 17 82066341 82066475 135 - 0.685 0.641 -0.187
ENSG00000169718 E050 2.379585 8.841250e-03 2.613013e-01 0.500343491 17 82066476 82066742 267 - 0.623 0.419 -0.979