ENSG00000169683

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306688 ENSG00000169683 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC45 protein_coding protein_coding 31.75984 50.36826 19.62236 4.484878 0.685138 -1.359568 13.023987 24.649393 4.311981 3.5369835 0.40525535 -2.5123726 0.36900000 0.49423333 0.22023333 -0.27400000 0.03023702 0.03023702 FALSE TRUE
ENST00000577638 ENSG00000169683 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC45 protein_coding protein_coding 31.75984 50.36826 19.62236 4.484878 0.685138 -1.359568 1.271287 1.369152 1.568042 0.4184038 0.09377991 0.1943542 0.04877083 0.02766667 0.08046667 0.05280000 0.09677205 0.03023702   FALSE
ENST00000583302 ENSG00000169683 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC45 protein_coding retained_intron 31.75984 50.36826 19.62236 4.484878 0.685138 -1.359568 6.170673 8.054755 6.061872 2.0190470 0.13756337 -0.4094894 0.21343333 0.15760000 0.31006667 0.15246667 0.09515078 0.03023702 FALSE TRUE
MSTRG.15323.4 ENSG00000169683 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC45 protein_coding   31.75984 50.36826 19.62236 4.484878 0.685138 -1.359568 3.499379 5.654947 2.624815 1.0032852 0.22232190 -1.1043611 0.11700000 0.11183333 0.13380000 0.02196667 0.81800037 0.03023702 TRUE TRUE
MSTRG.15323.5 ENSG00000169683 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC45 protein_coding   31.75984 50.36826 19.62236 4.484878 0.685138 -1.359568 3.594172 4.954273 2.773491 1.0895878 0.31011576 -0.8346870 0.11912917 0.09673333 0.14103333 0.04430000 0.55856760 0.03023702 TRUE TRUE
MSTRG.15323.6 ENSG00000169683 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC45 protein_coding   31.75984 50.36826 19.62236 4.484878 0.685138 -1.359568 1.392917 2.268181 1.520869 1.4672343 0.48190916 -0.5735319 0.05532083 0.04073333 0.07696667 0.03623333 0.77447543 0.03023702 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000169683 E001 0.9041907 0.1225957137 8.762109e-01   17 82023007 82023304 298 + 0.216 0.253 0.294
ENSG00000169683 E002 1.0765650 0.0154659734 6.802679e-01   17 82023305 82023320 16 + 0.216 0.294 0.589
ENSG00000169683 E003 3.8888326 0.0530060447 3.412347e-01 5.791960e-01 17 82023321 82023358 38 + 0.468 0.653 0.849
ENSG00000169683 E004 97.5634497 0.0026044864 1.414374e-04 1.997616e-03 17 82023359 82023553 195 + 1.741 1.932 0.642
ENSG00000169683 E005 107.8277308 0.0004256421 4.347561e-05 7.389069e-04 17 82023554 82023644 91 + 1.802 1.975 0.583
ENSG00000169683 E006 197.2613042 0.0003134293 4.123990e-02 1.579567e-01 17 82023645 82023863 219 + 2.164 2.216 0.174
ENSG00000169683 E007 15.6581353 0.0674180572 6.229027e-04 6.774461e-03 17 82023922 82024277 356 + 1.476 0.968 -1.803
ENSG00000169683 E008 108.5975319 0.0008784983 4.388269e-01 6.578430e-01 17 82024278 82024339 62 + 1.986 1.941 -0.151
ENSG00000169683 E009 161.9295122 0.0014087991 1.534065e-01 3.671979e-01 17 82024693 82024763 71 + 2.172 2.107 -0.218
ENSG00000169683 E010 232.9018275 0.0002836904 4.792334e-01 6.865945e-01 17 82025000 82025178 179 + 2.303 2.270 -0.110
ENSG00000169683 E011 259.2352604 0.0001930264 6.018293e-01 7.713812e-01 17 82025379 82025507 129 + 2.343 2.316 -0.090
ENSG00000169683 E012 39.4947312 0.0502147438 8.238789e-04 8.473962e-03 17 82026806 82026898 93 + 1.797 1.398 -1.363
ENSG00000169683 E013 268.0576777 0.0014351420 1.423266e-01 3.509189e-01 17 82026899 82027006 108 + 2.382 2.324 -0.194
ENSG00000169683 E014 160.0723071 0.0006084780 6.097671e-02 2.049610e-01 17 82027007 82027011 5 + 2.177 2.100 -0.256
ENSG00000169683 E015 203.9620361 0.0004244065 6.623259e-02 2.165707e-01 17 82027386 82027444 59 + 2.275 2.207 -0.227
ENSG00000169683 E016 190.9776313 0.0002969620 2.218598e-01 4.557449e-01 17 82027674 82027751 78 + 2.231 2.180 -0.170
ENSG00000169683 E017 262.1924434 0.0002796804 9.829835e-01 9.932771e-01 17 82028011 82028146 136 + 2.338 2.324 -0.046
ENSG00000169683 E018 193.5107092 0.0040338908 9.641670e-01 9.839477e-01 17 82028234 82028311 78 + 2.209 2.187 -0.076
ENSG00000169683 E019 255.4945677 0.0051194990 6.320093e-01 7.916981e-01 17 82028397 82028508 112 + 2.312 2.311 -0.005
ENSG00000169683 E020 245.3275163 0.0021580089 9.136779e-01 9.589479e-01 17 82028613 82028683 71 + 2.313 2.290 -0.080
ENSG00000169683 E021 75.6280161 0.0361710964 3.014491e-03 2.348841e-02 17 82028684 82028740 57 + 2.017 1.704 -1.055
ENSG00000169683 E022 152.4669174 0.0367481999 6.795616e-04 7.265042e-03 17 82028741 82029018 278 + 2.327 2.001 -1.092
ENSG00000169683 E023 88.7357198 0.0249056376 7.743629e-03 4.810500e-02 17 82029019 82029092 74 + 2.031 1.801 -0.773
ENSG00000169683 E024 273.4441344 0.0039357456 4.424083e-02 1.657133e-01 17 82029093 82029185 93 + 2.294 2.352 0.195
ENSG00000169683 E025 26.5570193 0.0656982175 1.219429e-02 6.723392e-02 17 82029186 82029232 47 + 1.593 1.258 -1.157
ENSG00000169683 E026 51.9391590 0.0401254064 1.928630e-02 9.345863e-02 17 82029385 82029542 158 + 1.820 1.564 -0.870
ENSG00000169683 E027 244.5913854 0.0002630869 3.239695e-04 3.973529e-03 17 82029543 82029635 93 + 2.221 2.312 0.305
ENSG00000169683 E028 310.7614754 0.0011515098 9.193207e-07 2.639422e-05 17 82030065 82030238 174 + 2.291 2.421 0.436
ENSG00000169683 E029 213.8664635 0.0088207209 2.092537e-04 2.775823e-03 17 82030319 82030466 148 + 2.084 2.265 0.607
ENSG00000169683 E030 371.9580867 0.0039234230 1.087117e-04 1.602443e-03 17 82030609 82031478 870 + 2.372 2.497 0.418